Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells

Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells

Porcine reproductive and respiratory syndrome virus (PRRSV) has a highly restricted tropism for cells of the monocyte-macrophage lineage, including porcine alveolar macrophages (PAMs). PRRSV entry into permissive cells involves several mediators in addition to two required host cell receptors, CD163...

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Bibliographic Details
Main Authors: Gaopeng Hou, Biyun Xue, Liangliang Li, Yuchen Nan, Lu Zhang, Kuokuo Li, Qin Zhao, Julian A. Hiscox, James P. Stewart, Chunyan Wu, Jingfei Wang, En-Min Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Microbiology
Subjects:
PRRSV
CD163
MYH9
protein–protein interaction
virus internalization
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01815/full

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