Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic Review
Background: Ovarian tissue cryopreservation and transplantation are the only available fertility techniques for prepubertal girls with cancer. Though autotransplantation carries a risk of reintroducing malignant cells, it can be avoided by identifying minimal infiltrative disease (MID) within ovaria...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/17/4199 |
| _version_ | 1797582806258286592 |
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| author | Monika Grubliauskaite M. E. Madeleine van der Perk Annelies M. E. Bos Annelot J. M. Meijer Zivile Gudleviciene Marry M. van den Heuvel-Eibrink Jelena Rascon |
| author_facet | Monika Grubliauskaite M. E. Madeleine van der Perk Annelies M. E. Bos Annelot J. M. Meijer Zivile Gudleviciene Marry M. van den Heuvel-Eibrink Jelena Rascon |
| author_sort | Monika Grubliauskaite |
| collection | DOAJ |
| description | Background: Ovarian tissue cryopreservation and transplantation are the only available fertility techniques for prepubertal girls with cancer. Though autotransplantation carries a risk of reintroducing malignant cells, it can be avoided by identifying minimal infiltrative disease (MID) within ovarian tissue. Methods: A broad search for peer-reviewed articles in the PubMed database was conducted in accordance with PRISMA guidelines up to March 2023. Search terms included ‘minimal residual disease’, ‘cryopreservation’, ‘ovarian’, ‘cancer’ and synonyms. Results: Out of 542 identified records, 17 were included. Ovarian tissues of at least 115 girls were evaluated and categorized as: hematological malignancies (<i>n</i> = 56; 48.7%), solid tumors (<i>n</i> = 42; 36.5%) and tumors of the central nervous system (<i>n</i> = 17; 14.8%). In ovarian tissue of 25 patients (21.7%), MID was detected using RT-qPCR, FISH or multicolor flow cytometry: 16 of them (64%) being ALL (<i>IgH</i> rearrangements with/without <i>TRG</i>, <i>BCL-ABL1</i>, <i>EA2-PBX1</i>, <i>TEL-AML1</i> fusion transcripts), 3 (12%) Ewing sarcoma (<i>EWS-FLI1</i> fusion transcript, <i>EWSR1</i> rearrangements), 3 (12%) CML (<i>BCR-ABL1</i> fusion transcript, <i>FLT3</i>) and 3 (12%) AML (leukemia-associated immunophenotypes, <i>BCR-ABL1</i> fusion transcript) patients. Conclusion: While the majority of malignancies were found to have a low risk of containing malignant cells in ovarian tissue, further studies are needed to ensure safe implementation of future fertility restoration in clinical practice. |
| first_indexed | 2024-03-10T23:26:50Z |
| format | Article |
| id | doaj.art-83d15218c1b14763aedafcfa8a645ee7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T23:26:50Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-83d15218c1b14763aedafcfa8a645ee72023-11-19T07:54:33ZengMDPI AGCancers2072-66942023-08-011517419910.3390/cancers15174199Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic ReviewMonika Grubliauskaite0M. E. Madeleine van der Perk1Annelies M. E. Bos2Annelot J. M. Meijer3Zivile Gudleviciene4Marry M. van den Heuvel-Eibrink5Jelena Rascon6Center for Pediatric Oncology and Hematology, Vilnius University Hospital Santaros Klinikos, Santariskiu Str. 4, LT-08406 Vilnius, LithuaniaPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The NetherlandsPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The NetherlandsPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The NetherlandsFaculty of Medicine, Vilnius University, M. K. Ciurlionio Str. 21/27, LT-03101 Vilnius, LithuaniaPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The NetherlandsCenter for Pediatric Oncology and Hematology, Vilnius University Hospital Santaros Klinikos, Santariskiu Str. 4, LT-08406 Vilnius, LithuaniaBackground: Ovarian tissue cryopreservation and transplantation are the only available fertility techniques for prepubertal girls with cancer. Though autotransplantation carries a risk of reintroducing malignant cells, it can be avoided by identifying minimal infiltrative disease (MID) within ovarian tissue. Methods: A broad search for peer-reviewed articles in the PubMed database was conducted in accordance with PRISMA guidelines up to March 2023. Search terms included ‘minimal residual disease’, ‘cryopreservation’, ‘ovarian’, ‘cancer’ and synonyms. Results: Out of 542 identified records, 17 were included. Ovarian tissues of at least 115 girls were evaluated and categorized as: hematological malignancies (<i>n</i> = 56; 48.7%), solid tumors (<i>n</i> = 42; 36.5%) and tumors of the central nervous system (<i>n</i> = 17; 14.8%). In ovarian tissue of 25 patients (21.7%), MID was detected using RT-qPCR, FISH or multicolor flow cytometry: 16 of them (64%) being ALL (<i>IgH</i> rearrangements with/without <i>TRG</i>, <i>BCL-ABL1</i>, <i>EA2-PBX1</i>, <i>TEL-AML1</i> fusion transcripts), 3 (12%) Ewing sarcoma (<i>EWS-FLI1</i> fusion transcript, <i>EWSR1</i> rearrangements), 3 (12%) CML (<i>BCR-ABL1</i> fusion transcript, <i>FLT3</i>) and 3 (12%) AML (leukemia-associated immunophenotypes, <i>BCR-ABL1</i> fusion transcript) patients. Conclusion: While the majority of malignancies were found to have a low risk of containing malignant cells in ovarian tissue, further studies are needed to ensure safe implementation of future fertility restoration in clinical practice.https://www.mdpi.com/2072-6694/15/17/4199fertility restorationovarian tissuecryopreservationcancer survivorspediatric patientsminimal infiltrative disease |
| spellingShingle | Monika Grubliauskaite M. E. Madeleine van der Perk Annelies M. E. Bos Annelot J. M. Meijer Zivile Gudleviciene Marry M. van den Heuvel-Eibrink Jelena Rascon Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic Review Cancers fertility restoration ovarian tissue cryopreservation cancer survivors pediatric patients minimal infiltrative disease |
| title | Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic Review |
| title_full | Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic Review |
| title_fullStr | Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic Review |
| title_full_unstemmed | Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic Review |
| title_short | Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use: A Systematic Review |
| title_sort | minimal infiltrative disease identification in cryopreserved ovarian tissue of girls with cancer for future use a systematic review |
| topic | fertility restoration ovarian tissue cryopreservation cancer survivors pediatric patients minimal infiltrative disease |
| url | https://www.mdpi.com/2072-6694/15/17/4199 |
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