Gut microbiota: effect of pubertal status
Abstract Background The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. Result The subjects (aged 5–15 years) were divided into non-pubertal (n = 42, male%: 66.7%) or pub...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-11-01
|
| Series: | BMC Microbiology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12866-020-02021-0 |
| _version_ | 1818163910743687168 |
|---|---|
| author | Xin Yuan Ruimin Chen Ying Zhang Xiangquan Lin Xiaohong Yang |
| author_facet | Xin Yuan Ruimin Chen Ying Zhang Xiangquan Lin Xiaohong Yang |
| author_sort | Xin Yuan |
| collection | DOAJ |
| description | Abstract Background The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. Result The subjects (aged 5–15 years) were divided into non-pubertal (n = 42, male%: 66.7%) or pubertal groups (n = 47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had members of the order Clostridiales, family Clostridiaceae, genus Coprobacillus which were significantly more prevalent than puberty subjects. Also, the pubertal subjects had members of class Betaproteobacteria, order Burkholderiales which were significantly more prevalent than the non-pubertal subjects. Their relative abundance was independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Ruminococcus, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone. Conclusions This is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels. |
| first_indexed | 2024-12-11T16:57:04Z |
| format | Article |
| id | doaj.art-83d2fa9affcb4bf0aaae58668116e182 |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-12-11T16:57:04Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-83d2fa9affcb4bf0aaae58668116e1822022-12-22T00:57:56ZengBMCBMC Microbiology1471-21802020-11-012011910.1186/s12866-020-02021-0Gut microbiota: effect of pubertal statusXin Yuan0Ruimin Chen1Ying Zhang2Xiangquan Lin3Xiaohong Yang4Department of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical UniversityDepartment of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical UniversityDepartment of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical UniversityDepartment of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical UniversityDepartment of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical UniversityAbstract Background The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. Result The subjects (aged 5–15 years) were divided into non-pubertal (n = 42, male%: 66.7%) or pubertal groups (n = 47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had members of the order Clostridiales, family Clostridiaceae, genus Coprobacillus which were significantly more prevalent than puberty subjects. Also, the pubertal subjects had members of class Betaproteobacteria, order Burkholderiales which were significantly more prevalent than the non-pubertal subjects. Their relative abundance was independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Ruminococcus, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone. Conclusions This is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels.http://link.springer.com/article/10.1186/s12866-020-02021-0PubertyChildrenAdolescent16 s rRNAGut microbiota |
| spellingShingle | Xin Yuan Ruimin Chen Ying Zhang Xiangquan Lin Xiaohong Yang Gut microbiota: effect of pubertal status BMC Microbiology Puberty Children Adolescent 16 s rRNA Gut microbiota |
| title | Gut microbiota: effect of pubertal status |
| title_full | Gut microbiota: effect of pubertal status |
| title_fullStr | Gut microbiota: effect of pubertal status |
| title_full_unstemmed | Gut microbiota: effect of pubertal status |
| title_short | Gut microbiota: effect of pubertal status |
| title_sort | gut microbiota effect of pubertal status |
| topic | Puberty Children Adolescent 16 s rRNA Gut microbiota |
| url | http://link.springer.com/article/10.1186/s12866-020-02021-0 |
| work_keys_str_mv | AT xinyuan gutmicrobiotaeffectofpubertalstatus AT ruiminchen gutmicrobiotaeffectofpubertalstatus AT yingzhang gutmicrobiotaeffectofpubertalstatus AT xiangquanlin gutmicrobiotaeffectofpubertalstatus AT xiaohongyang gutmicrobiotaeffectofpubertalstatus |