Discovery of novel MHC-B haplotypes in Chantecler chickens
ABSTRACT: The major histocompatibility complex (MHC) is a highly polymorphic cluster of genes which contribute to immune response. Located on chromosome 16, the chicken MHC has great influence over disease resistance and susceptibility. Through the use of a high-density SNP panel which encompasses t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579123004005 |
| _version_ | 1797739003736227840 |
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| author | Corie Darrington Haijiao Lin Jean-Marc Larivière Janet E. Fulton Xin Zhao |
| author_facet | Corie Darrington Haijiao Lin Jean-Marc Larivière Janet E. Fulton Xin Zhao |
| author_sort | Corie Darrington |
| collection | DOAJ |
| description | ABSTRACT: The major histocompatibility complex (MHC) is a highly polymorphic cluster of genes which contribute to immune response. Located on chromosome 16, the chicken MHC has great influence over disease resistance and susceptibility. Through the use of a high-density SNP panel which encompasses the MHC-B region, haplotypes can be easily identified. This study aims to use an MHC-B SNP panel to evaluate the MHC-B variability in the Chantecler breed. This breed is native to Quebec, Canada, and is a dual-purpose breed known for its strong resistance to extreme cold temperatures. The Chantecler breed faced a near extinction event in the 1970s, which most likely resulted in a genetic bottleneck and loss of diversity. Despite this, SNP haplotype diversity was observed among 4 Chantecler populations. A total of 8 haplotypes were observed. Of these haplotypes, 6 were previously defined in other breeds, and the other 2 were unique to the Chantecler. Within the populations, the number of haplotypes ranged from 4 to 7, with 3 haplotypes, including the novel BSNP-Chant01, being present in all the groups. This study shows existence of reasonable diversity in the MHC-B region of the Chantecler breed and our results further contribute to understanding the variability of this region in chickens. |
| first_indexed | 2024-03-12T13:51:05Z |
| format | Article |
| id | doaj.art-83d381ad775c4cdbacbbfd3285f5f63e |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-03-12T13:51:05Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-83d381ad775c4cdbacbbfd3285f5f63e2023-08-23T04:32:40ZengElsevierPoultry Science0032-57912023-09-011029102881Discovery of novel MHC-B haplotypes in Chantecler chickensCorie Darrington0Haijiao Lin1Jean-Marc Larivière2Janet E. Fulton3Xin Zhao4McGill University, Montreal, QC, CanadaMcGill University, Montreal, QC, CanadaInstitut de Technologie Agroalimentaire du Québec, La Pocatiere, QC, CanadaHy-Line International, Dallas Center, IA, USAMcGill University, Montreal, QC, Canada; Corresponding author:ABSTRACT: The major histocompatibility complex (MHC) is a highly polymorphic cluster of genes which contribute to immune response. Located on chromosome 16, the chicken MHC has great influence over disease resistance and susceptibility. Through the use of a high-density SNP panel which encompasses the MHC-B region, haplotypes can be easily identified. This study aims to use an MHC-B SNP panel to evaluate the MHC-B variability in the Chantecler breed. This breed is native to Quebec, Canada, and is a dual-purpose breed known for its strong resistance to extreme cold temperatures. The Chantecler breed faced a near extinction event in the 1970s, which most likely resulted in a genetic bottleneck and loss of diversity. Despite this, SNP haplotype diversity was observed among 4 Chantecler populations. A total of 8 haplotypes were observed. Of these haplotypes, 6 were previously defined in other breeds, and the other 2 were unique to the Chantecler. Within the populations, the number of haplotypes ranged from 4 to 7, with 3 haplotypes, including the novel BSNP-Chant01, being present in all the groups. This study shows existence of reasonable diversity in the MHC-B region of the Chantecler breed and our results further contribute to understanding the variability of this region in chickens.http://www.sciencedirect.com/science/article/pii/S0032579123004005Chanteclermajor histocompatibility complex (MHC)SNP genotypehaplotype |
| spellingShingle | Corie Darrington Haijiao Lin Jean-Marc Larivière Janet E. Fulton Xin Zhao Discovery of novel MHC-B haplotypes in Chantecler chickens Poultry Science Chantecler major histocompatibility complex (MHC) SNP genotype haplotype |
| title | Discovery of novel MHC-B haplotypes in Chantecler chickens |
| title_full | Discovery of novel MHC-B haplotypes in Chantecler chickens |
| title_fullStr | Discovery of novel MHC-B haplotypes in Chantecler chickens |
| title_full_unstemmed | Discovery of novel MHC-B haplotypes in Chantecler chickens |
| title_short | Discovery of novel MHC-B haplotypes in Chantecler chickens |
| title_sort | discovery of novel mhc b haplotypes in chantecler chickens |
| topic | Chantecler major histocompatibility complex (MHC) SNP genotype haplotype |
| url | http://www.sciencedirect.com/science/article/pii/S0032579123004005 |
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