Effect of Moxifloxacin-Triple Therapy Versus Clarithromycin-Triple Therapy for the Eradication of Helicobacter Pylori Infections Regarding to Age and BMI.
Helicobacter pylori (H. Pylori) is one of the most common infectious human pathogens, which infected more than (50%) of the populations worldwide. • pylori induce inflammation, which causes of upper gastrointestinal illnesses including dyspepsia, peptic ulcer diseases, gastroesop...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2019-03-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/541 |
| _version_ | 1797223934033133568 |
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| author | Ahmed Mansur Kadhim Mohammed Mahmood Mohammed Hussein Muhammad Hassan |
| author_facet | Ahmed Mansur Kadhim Mohammed Mahmood Mohammed Hussein Muhammad Hassan |
| author_sort | Ahmed Mansur Kadhim |
| collection | DOAJ |
| description |
Helicobacter pylori (H. Pylori) is one of the most common infectious human pathogens, which infected more
than (50%) of the populations worldwide.
• pylori induce inflammation, which causes of upper gastrointestinal illnesses including dyspepsia, peptic ulcer
diseases, gastroesophageal reflux disease and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. It is important to use a greatly effective and better tolerated eradication regimen. In this study, fifty newly diagnosed adult patients with H. pylori infection were included, they were allocated into two groups with two different treatment regimens for H. pylori eradications; Group A (25 patients) received oral conventional clarithromycin-triple therapy for 14 days. Group B (25 patients) received oral moxifloxacin triple therapy for 14 days. The results reported in this study indicated a significant higher eradication rate of triple moxifloxacin regimen (80%) of patients with H. pylori infections compared to that of triple clarithromycin regimen (52%). In the present study, using different H.pylori eradication regimens for patients with different age groups demonstrated no statistically significant differences in eradication rate achieved (p< 0.05). The result of this study showed that triple moxifloxacin therapy produced a significant higher eradication rate than clarithromycin triple therapy among normal weight patients with H. pylori infection (100% and 50% respectively (p=0.032)), while there was no significance difference among overweight and obese patients (p< 0.05) between the two groups. The present study concluded that the administration of moxifloxacin triple regimen for H. pylori eradication, demonstrated eradication effectiveness was significantly higher compared to that of clarithromycin triple regimen.
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| first_indexed | 2024-04-24T13:45:06Z |
| format | Article |
| id | doaj.art-83d3c00501604bf19c897e9403947dc2 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:06Z |
| publishDate | 2019-03-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-83d3c00501604bf19c897e9403947dc22024-04-04T06:57:59ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2019-03-0119110.32947/ajps.v19i1.541Effect of Moxifloxacin-Triple Therapy Versus Clarithromycin-Triple Therapy for the Eradication of Helicobacter Pylori Infections Regarding to Age and BMI.Ahmed Mansur Kadhim0Mohammed Mahmood Mohammed1Hussein Muhammad Hassan2*Clinical pharmacist, Wassit health directory, IraqDepartment of Clinical Pharmacy/College of Pharmacy/Al-Mustansiriya University, IraqInternal medicine specialist, AL-Zahraa Teaching Hospital/Wassit province, Iraq Helicobacter pylori (H. Pylori) is one of the most common infectious human pathogens, which infected more than (50%) of the populations worldwide. • pylori induce inflammation, which causes of upper gastrointestinal illnesses including dyspepsia, peptic ulcer diseases, gastroesophageal reflux disease and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. It is important to use a greatly effective and better tolerated eradication regimen. In this study, fifty newly diagnosed adult patients with H. pylori infection were included, they were allocated into two groups with two different treatment regimens for H. pylori eradications; Group A (25 patients) received oral conventional clarithromycin-triple therapy for 14 days. Group B (25 patients) received oral moxifloxacin triple therapy for 14 days. The results reported in this study indicated a significant higher eradication rate of triple moxifloxacin regimen (80%) of patients with H. pylori infections compared to that of triple clarithromycin regimen (52%). In the present study, using different H.pylori eradication regimens for patients with different age groups demonstrated no statistically significant differences in eradication rate achieved (p< 0.05). The result of this study showed that triple moxifloxacin therapy produced a significant higher eradication rate than clarithromycin triple therapy among normal weight patients with H. pylori infection (100% and 50% respectively (p=0.032)), while there was no significance difference among overweight and obese patients (p< 0.05) between the two groups. The present study concluded that the administration of moxifloxacin triple regimen for H. pylori eradication, demonstrated eradication effectiveness was significantly higher compared to that of clarithromycin triple regimen. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/541H. pylori, moxifloxacin, clarithromycin, triple therapy, age, BMI. |
| spellingShingle | Ahmed Mansur Kadhim Mohammed Mahmood Mohammed Hussein Muhammad Hassan Effect of Moxifloxacin-Triple Therapy Versus Clarithromycin-Triple Therapy for the Eradication of Helicobacter Pylori Infections Regarding to Age and BMI. Al-Mustansiriyah Journal of Pharmaceutical Sciences H. pylori, moxifloxacin, clarithromycin, triple therapy, age, BMI. |
| title | Effect of Moxifloxacin-Triple Therapy Versus Clarithromycin-Triple Therapy for the Eradication of Helicobacter Pylori Infections Regarding to Age and BMI. |
| title_full | Effect of Moxifloxacin-Triple Therapy Versus Clarithromycin-Triple Therapy for the Eradication of Helicobacter Pylori Infections Regarding to Age and BMI. |
| title_fullStr | Effect of Moxifloxacin-Triple Therapy Versus Clarithromycin-Triple Therapy for the Eradication of Helicobacter Pylori Infections Regarding to Age and BMI. |
| title_full_unstemmed | Effect of Moxifloxacin-Triple Therapy Versus Clarithromycin-Triple Therapy for the Eradication of Helicobacter Pylori Infections Regarding to Age and BMI. |
| title_short | Effect of Moxifloxacin-Triple Therapy Versus Clarithromycin-Triple Therapy for the Eradication of Helicobacter Pylori Infections Regarding to Age and BMI. |
| title_sort | effect of moxifloxacin triple therapy versus clarithromycin triple therapy for the eradication of helicobacter pylori infections regarding to age and bmi |
| topic | H. pylori, moxifloxacin, clarithromycin, triple therapy, age, BMI. |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/541 |
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