Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation
Solubility is one of the major factors which affects several therapeutic mioeties in terms of their therapeutic efficacy. In the current study, we presented a porous and amorphous nanometrices system for the enhancement of the solubility of acyclovir. The polymeric network was fabricated by crosslin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmats.2023.1257047/full |
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| author | Ayesha Umar Kashif Barkat Syed Nisar Hussain Shah Muhammad Umer Ashraf Syed Faisal Badshah Akhtar Ali Irfan Anjum Yousef A. Bin Jardan Hiba-Allah Nafidi Musaab Dauelbait Mohammed Bourhia |
| author_facet | Ayesha Umar Kashif Barkat Syed Nisar Hussain Shah Muhammad Umer Ashraf Syed Faisal Badshah Akhtar Ali Irfan Anjum Yousef A. Bin Jardan Hiba-Allah Nafidi Musaab Dauelbait Mohammed Bourhia |
| author_sort | Ayesha Umar |
| collection | DOAJ |
| description | Solubility is one of the major factors which affects several therapeutic mioeties in terms of their therapeutic efficacy. In the current study, we presented a porous and amorphous nanometrices system for the enhancement of the solubility of acyclovir. The polymeric network was fabricated by crosslinking polyethylene glycol-6000, polycaprolactone, and β-cyclodextrin with methacrylic acid by optimizing free radical polymerization technique using methylene bisacrylamide as a crosslinking agent. The formulated nanometrices were then characterized by zetasizer, FTIR, PXRD, Scanning electron microscopy, Thermogravimetric analysis, swelling, sol-gel fraction, drug loading, stability, solubility, and in-vitro dissolution analysis. Since the formulated system has to be administered orally, therefore to determine the in-vivo biocompatibility, nanometrices were administered orally to experimental animals. SEM images provided a rough and porous structure while PXRD showed an amorphous diffractogram of the unloaded and loaded nanometrices. Moreover, the particle size of the optimum loaded formulation was 25 nm higher than unloaded nanometrices due to the repulsion of the loaded drug. A significant loading of the drug with enhanced solubility and dissolution profiles was observed for the poorly soluble drug. The dissolution profile was quite satisfactory as compared to the marketed brand of drug which depicted that the solubility of the drug has been enhanced. Toxicity study conducted on rabbits confirmed the biocompatibility of the nanometrices. The systematic method of preparation, enhanced solubility and high dissolution profile of the formulated nanometrices may be proved as a promising technique to enhance the solubility of poorly aqueous soluble therapeutic agents. |
| first_indexed | 2024-03-11T12:23:53Z |
| format | Article |
| id | doaj.art-83d5a4b7a0b94a849e1bbbc8749c5260 |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-03-11T12:23:53Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-83d5a4b7a0b94a849e1bbbc8749c52602023-11-06T15:52:56ZengFrontiers Media S.A.Frontiers in Materials2296-80162023-11-011010.3389/fmats.2023.12570471257047Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluationAyesha Umar0Kashif Barkat1Syed Nisar Hussain Shah2Muhammad Umer Ashraf3Syed Faisal Badshah4Akhtar Ali5Irfan Anjum6Yousef A. Bin Jardan7Hiba-Allah Nafidi8Musaab Dauelbait9Mohammed Bourhia10Faculty of Pharmacy, University of Lahore, Lahore, PakistanFaculty of Pharmacy, University of Lahore, Lahore, PakistanFaculty of Pharmacy, University of Lahore, Lahore, PakistanFaculty of Pharmacy, University of Lahore, Lahore, PakistanDepartment of Pharmacy, Faculty of Medical and Health Sciences, University of Poonch, Rawalakot, PakistanDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Punjab, PakistanDepartment of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, PakistanDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Food Science, Faculty of Agricultural and Food Sciences, Laval University, Quebec City, CanadaDepartment of Scientific Translation, Faculty of Translation, University of Bahri, Khartoum, SudanDepartment of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Ibn Zohr University, Laayoune, MoroccoSolubility is one of the major factors which affects several therapeutic mioeties in terms of their therapeutic efficacy. In the current study, we presented a porous and amorphous nanometrices system for the enhancement of the solubility of acyclovir. The polymeric network was fabricated by crosslinking polyethylene glycol-6000, polycaprolactone, and β-cyclodextrin with methacrylic acid by optimizing free radical polymerization technique using methylene bisacrylamide as a crosslinking agent. The formulated nanometrices were then characterized by zetasizer, FTIR, PXRD, Scanning electron microscopy, Thermogravimetric analysis, swelling, sol-gel fraction, drug loading, stability, solubility, and in-vitro dissolution analysis. Since the formulated system has to be administered orally, therefore to determine the in-vivo biocompatibility, nanometrices were administered orally to experimental animals. SEM images provided a rough and porous structure while PXRD showed an amorphous diffractogram of the unloaded and loaded nanometrices. Moreover, the particle size of the optimum loaded formulation was 25 nm higher than unloaded nanometrices due to the repulsion of the loaded drug. A significant loading of the drug with enhanced solubility and dissolution profiles was observed for the poorly soluble drug. The dissolution profile was quite satisfactory as compared to the marketed brand of drug which depicted that the solubility of the drug has been enhanced. Toxicity study conducted on rabbits confirmed the biocompatibility of the nanometrices. The systematic method of preparation, enhanced solubility and high dissolution profile of the formulated nanometrices may be proved as a promising technique to enhance the solubility of poorly aqueous soluble therapeutic agents.https://www.frontiersin.org/articles/10.3389/fmats.2023.1257047/fullsolubilitynanometricesacyclovirthermal analysistoxicity studies |
| spellingShingle | Ayesha Umar Kashif Barkat Syed Nisar Hussain Shah Muhammad Umer Ashraf Syed Faisal Badshah Akhtar Ali Irfan Anjum Yousef A. Bin Jardan Hiba-Allah Nafidi Musaab Dauelbait Mohammed Bourhia Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation Frontiers in Materials solubility nanometrices acyclovir thermal analysis toxicity studies |
| title | Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation |
| title_full | Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation |
| title_fullStr | Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation |
| title_full_unstemmed | Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation |
| title_short | Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation |
| title_sort | porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir characterization and toxicological evaluation |
| topic | solubility nanometrices acyclovir thermal analysis toxicity studies |
| url | https://www.frontiersin.org/articles/10.3389/fmats.2023.1257047/full |
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