Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care Unit
Healthcare-associated infections (HAIs) are a global public health issue with clinical and socioeconomic consequences. These infections are important indices for the quality of healthcare services which are serious complications that should be addressed in pediatric intensive care units (PICUs). Thi...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-08-01
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| Series: | The Journal of Pediatric Academy |
| Subjects: | |
| Online Access: | https://jpediatricacademy.com/index.php/jpa/article/view/189 |
| _version_ | 1797767404896387072 |
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| author | Benhur Sirvan Cetin Ayşegül Şahin Cemile Altay Kürkçü Fatma Küçük Pınar Sağıroğlu Başak Nur Akyıldız |
| author_facet | Benhur Sirvan Cetin Ayşegül Şahin Cemile Altay Kürkçü Fatma Küçük Pınar Sağıroğlu Başak Nur Akyıldız |
| author_sort | Benhur Sirvan Cetin |
| collection | DOAJ |
| description | Healthcare-associated infections (HAIs) are a global public health issue with clinical and socioeconomic consequences. These infections are important indices for the quality of healthcare services which are serious complications that should be addressed in pediatric intensive care units (PICUs). This study aimed to retrospectively examine the bacterial HAIs, the frequency of isolated pathogen microorganisms, the areas of infection, and the antibiotic susceptibility recorded in the surveillance system in our Pediatric Intensive Care Unit for five years between 01.01.2015 and 31.12.2019. Two thousand five hundred forty-five patients were admitted to the pediatric intensive care unit during the study period and treated. One-hundred ninety HAIs were detected in 99 patients. In the study, gram-negative microorganisms were most commonly seen (160/190). Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella spp. were the most common bacteria. Enterococcus spp. and coagulase-negative staphylococci were the most common gram-positive microorganisms. The mortality rate of a bacterial HAI was 40.4%. There was no resistance against vancomycin in Gram-positive microorganisms. The resistance rate against methicillin was 100% in coagulase-negative staphylococci and 50% in S. aureus strains. The cumulative rate of carbapenem resistance was found as 76.1% in Pseudomonas aeruginosa, 45.2% in Klebsiella spp. and 0% in Escherichia coli. In 2019, the resistance rate against colistin in Klebsiella spp. and Pseudomonas aeruginosa were 46.2% (6/13) and 20% (1/5), respectively. The resistance rate against carbapenem and colistin was 81.1% and 0% in Acinetobacter baumannii. It was observed that the use of carbapenem before an infection episode increased significantly, and the rate of carbapenem resistance reached 100% over the years in Pseudomonas aeruginosa and Klebsiella spp. A significant proportion of the isolates were multidrug-resistant strains, significantly threatening survival. Implementation of effective preventive strategies to combat the emergence of antibiotic resistance is urgently needed. |
| first_indexed | 2024-03-12T20:38:14Z |
| format | Article |
| id | doaj.art-83d8df6877d944b7adf10a6ccf8f4572 |
| institution | Directory Open Access Journal |
| issn | 2718-0875 |
| language | English |
| last_indexed | 2024-03-12T20:38:14Z |
| publishDate | 2022-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | The Journal of Pediatric Academy |
| spelling | doaj.art-83d8df6877d944b7adf10a6ccf8f45722023-08-01T11:23:15ZengGalenos Publishing HouseThe Journal of Pediatric Academy2718-08752022-08-0132788410.51271/jpea-2022-189139Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care UnitBenhur Sirvan Cetin0https://orcid.org/0000-0002-8470-4907Ayşegül Şahin1Cemile Altay Kürkçü2Fatma Küçük3Pınar Sağıroğlu4https://orcid.org/0000-0001-6742-0200Başak Nur Akyıldız5https://orcid.org/0000-0001-8540-0625Erciyes UniversityŞanlıurfa Provincial Health Directorate Akçakale State HospitalErciyes University, Faculty of Medicine, Infection Control Committee, KayseriErciyes University, Faculty of Medicine, Infection Control Committee, KayseriErciyes University, Faculty of Medicine, Department of Medical MicrobiologyErciyes University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Intensive Care Unit, Kayseri, TurkeyHealthcare-associated infections (HAIs) are a global public health issue with clinical and socioeconomic consequences. These infections are important indices for the quality of healthcare services which are serious complications that should be addressed in pediatric intensive care units (PICUs). This study aimed to retrospectively examine the bacterial HAIs, the frequency of isolated pathogen microorganisms, the areas of infection, and the antibiotic susceptibility recorded in the surveillance system in our Pediatric Intensive Care Unit for five years between 01.01.2015 and 31.12.2019. Two thousand five hundred forty-five patients were admitted to the pediatric intensive care unit during the study period and treated. One-hundred ninety HAIs were detected in 99 patients. In the study, gram-negative microorganisms were most commonly seen (160/190). Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella spp. were the most common bacteria. Enterococcus spp. and coagulase-negative staphylococci were the most common gram-positive microorganisms. The mortality rate of a bacterial HAI was 40.4%. There was no resistance against vancomycin in Gram-positive microorganisms. The resistance rate against methicillin was 100% in coagulase-negative staphylococci and 50% in S. aureus strains. The cumulative rate of carbapenem resistance was found as 76.1% in Pseudomonas aeruginosa, 45.2% in Klebsiella spp. and 0% in Escherichia coli. In 2019, the resistance rate against colistin in Klebsiella spp. and Pseudomonas aeruginosa were 46.2% (6/13) and 20% (1/5), respectively. The resistance rate against carbapenem and colistin was 81.1% and 0% in Acinetobacter baumannii. It was observed that the use of carbapenem before an infection episode increased significantly, and the rate of carbapenem resistance reached 100% over the years in Pseudomonas aeruginosa and Klebsiella spp. A significant proportion of the isolates were multidrug-resistant strains, significantly threatening survival. Implementation of effective preventive strategies to combat the emergence of antibiotic resistance is urgently needed.https://jpediatricacademy.com/index.php/jpa/article/view/189healthcare-associated infectionsantibiotic resistancepediatricintensive caremortality |
| spellingShingle | Benhur Sirvan Cetin Ayşegül Şahin Cemile Altay Kürkçü Fatma Küçük Pınar Sağıroğlu Başak Nur Akyıldız Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care Unit The Journal of Pediatric Academy healthcare-associated infections antibiotic resistance pediatric intensive care mortality |
| title | Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care Unit |
| title_full | Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care Unit |
| title_fullStr | Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care Unit |
| title_full_unstemmed | Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care Unit |
| title_short | Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care Unit |
| title_sort | bacteriological profile and antimicrobial resistance pattern among healthcare associated infections in a pediatric intensive care unit |
| topic | healthcare-associated infections antibiotic resistance pediatric intensive care mortality |
| url | https://jpediatricacademy.com/index.php/jpa/article/view/189 |
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