Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study
BackgroundAge is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1048375/full |
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| author | Luisa Lampignano Alfredo Niro Fabio Castellana Ilaria Bortone Roberta Zupo Sarah Tirelli Rossella Tatoli Chiara Griseta Sara De Nucci Annamaria Sila Giovanni De Pergola Caterina Conte Caterina Conte Giovanni Alessio Francesco Boscia Giancarlo Sborgia Eye Clinic Research Group Gianluigi Giannelli Rodolfo Sardone Giulia Maria Pia Bisceglia Rosa Buonamassa Flavio Cassano Arcangelo Clemente Pierfrancesco Digregorio Roberta Galati Marida Gaudiomonte Antonella Guglielmi Luca Landini Francesca Palumbo Pasquale Pasculli Giovanni Petruzzella Michele Santoro Giacomo Scotti Roberto Semeraro |
| author_facet | Luisa Lampignano Alfredo Niro Fabio Castellana Ilaria Bortone Roberta Zupo Sarah Tirelli Rossella Tatoli Chiara Griseta Sara De Nucci Annamaria Sila Giovanni De Pergola Caterina Conte Caterina Conte Giovanni Alessio Francesco Boscia Giancarlo Sborgia Eye Clinic Research Group Gianluigi Giannelli Rodolfo Sardone Giulia Maria Pia Bisceglia Rosa Buonamassa Flavio Cassano Arcangelo Clemente Pierfrancesco Digregorio Roberta Galati Marida Gaudiomonte Antonella Guglielmi Luca Landini Francesca Palumbo Pasquale Pasculli Giovanni Petruzzella Michele Santoro Giacomo Scotti Roberto Semeraro |
| author_sort | Luisa Lampignano |
| collection | DOAJ |
| description | BackgroundAge is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study.MethodsRetinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A). Liver fibrosis risk was taken as the fibrosis-4 (FIB-4) score. Generalized linear models (logistic regression) were used to estimate the association effect between each unit increase of OCT and OCT-A parameters as independent variables and a FIB-4 ≥ 2.67 score as an outcome. Generalized additive models were used to assess the non-linear association between OCT-A features and the linear FIB-4 score.ResultsIncreased gangliar cell complex (GCC) thickness was inversely associated with a FIB-4 score above the cut-off in both the raw model (OR: 0.98; 95% CI: 0.96–0.99; SE: 0.01) and after adjustment for age, sex, education, hypertension, diabetes, total cholesterol, and triglycerides (OR: 0.98; 95% CI: 0.97–0.99; SE: 0.01).ConclusionOur findings add to the growing volume of scientific literature demonstrating that liver fibrosis is associated with retinal neurodegeneration. This study raises a number of new questions, including whether OCT-A may be used to track the progression of metabolic abnormalities and define exact thresholds for predicting and classifying liver disease. |
| first_indexed | 2024-04-12T01:06:38Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T01:06:38Z |
| publishDate | 2022-12-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-83d98f03985f42078360fc4801d8937a2022-12-22T03:54:15ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-12-011610.3389/fnins.2022.10483751048375Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia studyLuisa Lampignano0Alfredo Niro1Fabio Castellana2Ilaria Bortone3Roberta Zupo4Sarah Tirelli5Rossella Tatoli6Chiara Griseta7Sara De Nucci8Annamaria Sila9Giovanni De Pergola10Caterina Conte11Caterina Conte12Giovanni Alessio13Francesco Boscia14Giancarlo Sborgia15Eye Clinic Research GroupGianluigi Giannelli16Rodolfo Sardone17Giulia Maria Pia BiscegliaRosa BuonamassaFlavio CassanoArcangelo ClementePierfrancesco DigregorioRoberta GalatiMarida GaudiomonteAntonella GuglielmiLuca LandiniFrancesca PalumboPasquale PasculliGiovanni PetruzzellaMichele SantoroGiacomo ScottiRoberto SemeraroUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyEye Clinic, Hospital “SS. Annunziata”, Azienda Sanitaria Locale (ASL) Taranto, Taranto, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Geriatrics and Internal Medicine, National Institute of Gastroenterology “Saverio de Bellis”, Research Hospital, Bari, ItalyDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, ItalyDepartment of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, ItalyScientific Direction, National Institute of Gastroenterology IRCCS “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyUnit of Research Methodology and Data Sciences for Population Health, “Salus in Apulia Study”, National Institute of Gastroenterology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Saverio de Bellis”, Research Hospital, Castellana Grotte, ItalyBackgroundAge is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study.MethodsRetinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A). Liver fibrosis risk was taken as the fibrosis-4 (FIB-4) score. Generalized linear models (logistic regression) were used to estimate the association effect between each unit increase of OCT and OCT-A parameters as independent variables and a FIB-4 ≥ 2.67 score as an outcome. Generalized additive models were used to assess the non-linear association between OCT-A features and the linear FIB-4 score.ResultsIncreased gangliar cell complex (GCC) thickness was inversely associated with a FIB-4 score above the cut-off in both the raw model (OR: 0.98; 95% CI: 0.96–0.99; SE: 0.01) and after adjustment for age, sex, education, hypertension, diabetes, total cholesterol, and triglycerides (OR: 0.98; 95% CI: 0.97–0.99; SE: 0.01).ConclusionOur findings add to the growing volume of scientific literature demonstrating that liver fibrosis is associated with retinal neurodegeneration. This study raises a number of new questions, including whether OCT-A may be used to track the progression of metabolic abnormalities and define exact thresholds for predicting and classifying liver disease.https://www.frontiersin.org/articles/10.3389/fnins.2022.1048375/fullliverfibrosisretinaolder populationaging |
| spellingShingle | Luisa Lampignano Alfredo Niro Fabio Castellana Ilaria Bortone Roberta Zupo Sarah Tirelli Rossella Tatoli Chiara Griseta Sara De Nucci Annamaria Sila Giovanni De Pergola Caterina Conte Caterina Conte Giovanni Alessio Francesco Boscia Giancarlo Sborgia Eye Clinic Research Group Gianluigi Giannelli Rodolfo Sardone Giulia Maria Pia Bisceglia Rosa Buonamassa Flavio Cassano Arcangelo Clemente Pierfrancesco Digregorio Roberta Galati Marida Gaudiomonte Antonella Guglielmi Luca Landini Francesca Palumbo Pasquale Pasculli Giovanni Petruzzella Michele Santoro Giacomo Scotti Roberto Semeraro Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study Frontiers in Neuroscience liver fibrosis retina older population aging |
| title | Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study |
| title_full | Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study |
| title_fullStr | Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study |
| title_full_unstemmed | Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study |
| title_short | Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study |
| title_sort | liver fibrosis and retinal features in an older mediterranean population results from the salus in apulia study |
| topic | liver fibrosis retina older population aging |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1048375/full |
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