Diagnostic value of MRI for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients: Diffusion-weig
Objective: Non-invasive preoperative detection of axillary nodal metastasis is beneficial for the outcome of breast cancer patients. We aimed to determine the value of DW MRI, ADC and their combination with MRI morphological criteria in detecting axillary metastasis. Methods: We included recently di...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-06-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X16300109 |
| _version_ | 1819149676859883520 |
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| author | Fatma Zaiton Samar M. Shehata Mohamad H. Abo Warda Mohamad A. Alekrashy |
| author_facet | Fatma Zaiton Samar M. Shehata Mohamad H. Abo Warda Mohamad A. Alekrashy |
| author_sort | Fatma Zaiton |
| collection | DOAJ |
| description | Objective: Non-invasive preoperative detection of axillary nodal metastasis is beneficial for the outcome of breast cancer patients. We aimed to determine the value of DW MRI, ADC and their combination with MRI morphological criteria in detecting axillary metastasis.
Methods: We included recently diagnosed forty breast cancer patients. MRI morphological criteria, signal intensity on DWI, and ADC value were assessed and compared between metastatic and non-metastatic LNs using histopathological findings as reference standard. Sensitivity, specificity, PPV, NPV and accuracy for each variable and cutoff value of ADC were evaluated.
Results: No statistically significant difference between metastatic and non-metastatic LNs in short axis diameter or L/S ratio (p value: 0.87 and 0.82 respectively); however, loss of fatty hilum, high signal intensity on DWI and low ADC value were significant with increasing sensitivity on their combination. The mean ADC was 0.96 ± 0.9 × 10−3 mm2/s for metastatic and 1.53 ± 0.6 × 10−3 mm2/s for benign LNs with cutoff value 1.09 × 10−3 mm2/s and sensitivity (94.5%), specificity (93.6%), PPV (96%), NPV (94.7%) and accuracy (95.6%).
Conclusion: DW-MRI and ADC per se or in combination with loss of the fatty hila is a promising and supportive tool for detection of axillary LNs metastasis. |
| first_indexed | 2024-12-22T14:05:24Z |
| format | Article |
| id | doaj.art-83da878e3ec74171a686ab13dbee050d |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-22T14:05:24Z |
| publishDate | 2016-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-83da878e3ec74171a686ab13dbee050d2022-12-21T18:23:18ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2016-06-0147265966710.1016/j.ejrnm.2016.03.008Diagnostic value of MRI for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients: Diffusion-weigFatma Zaiton0Samar M. Shehata1Mohamad H. Abo Warda2Mohamad A. Alekrashy3Diagnostic Radiology Department, Zagazig University, EgyptDiagnostic Radiology Department, Zagazig University, EgyptDiagnostic Radiology Department, Zagazig University, EgyptSurgery Department, Zagazig University, EgyptObjective: Non-invasive preoperative detection of axillary nodal metastasis is beneficial for the outcome of breast cancer patients. We aimed to determine the value of DW MRI, ADC and their combination with MRI morphological criteria in detecting axillary metastasis. Methods: We included recently diagnosed forty breast cancer patients. MRI morphological criteria, signal intensity on DWI, and ADC value were assessed and compared between metastatic and non-metastatic LNs using histopathological findings as reference standard. Sensitivity, specificity, PPV, NPV and accuracy for each variable and cutoff value of ADC were evaluated. Results: No statistically significant difference between metastatic and non-metastatic LNs in short axis diameter or L/S ratio (p value: 0.87 and 0.82 respectively); however, loss of fatty hilum, high signal intensity on DWI and low ADC value were significant with increasing sensitivity on their combination. The mean ADC was 0.96 ± 0.9 × 10−3 mm2/s for metastatic and 1.53 ± 0.6 × 10−3 mm2/s for benign LNs with cutoff value 1.09 × 10−3 mm2/s and sensitivity (94.5%), specificity (93.6%), PPV (96%), NPV (94.7%) and accuracy (95.6%). Conclusion: DW-MRI and ADC per se or in combination with loss of the fatty hila is a promising and supportive tool for detection of axillary LNs metastasis.http://www.sciencedirect.com/science/article/pii/S0378603X16300109Breast cancerAxillary nodal metastasesDiffusion weighted MRI |
| spellingShingle | Fatma Zaiton Samar M. Shehata Mohamad H. Abo Warda Mohamad A. Alekrashy Diagnostic value of MRI for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients: Diffusion-weig The Egyptian Journal of Radiology and Nuclear Medicine Breast cancer Axillary nodal metastases Diffusion weighted MRI |
| title | Diagnostic value of MRI for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients: Diffusion-weig |
| title_full | Diagnostic value of MRI for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients: Diffusion-weig |
| title_fullStr | Diagnostic value of MRI for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients: Diffusion-weig |
| title_full_unstemmed | Diagnostic value of MRI for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients: Diffusion-weig |
| title_short | Diagnostic value of MRI for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients: Diffusion-weig |
| title_sort | diagnostic value of mri for predicting axillary lymph nodes metastasis in newly diagnosed breast cancer patients diffusion weig |
| topic | Breast cancer Axillary nodal metastases Diffusion weighted MRI |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X16300109 |
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