Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control study
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system. However, whether and how cortical changes occur in NMOSD with normal-appearing brain tissue, or whether any cortical changes correlate with clinical characteristics, is not complete...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=11;spage=2520;epage=2525;aulast=Huang |
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| author | Chuxin Huang Yanyu Li Yanjing Chen Xuan Liao Huiting Zhang Zhiyuan Wang Jun Liu Wei Lu |
| author_facet | Chuxin Huang Yanyu Li Yanjing Chen Xuan Liao Huiting Zhang Zhiyuan Wang Jun Liu Wei Lu |
| author_sort | Chuxin Huang |
| collection | DOAJ |
| description | Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system. However, whether and how cortical changes occur in NMOSD with normal-appearing brain tissue, or whether any cortical changes correlate with clinical characteristics, is not completely clear. The current study recruited 43 patients with NMOSD who had normal-appearing brain tissue and 45 healthy controls matched for age, sex, and educational background from December 2020 to February 2022. A surface-based morphological analysis of high-resolution T1-weighted structural magnetic resonance images was used to calculate the cortical thickness, sulcal depth, and gyrification index. Analysis showed that cortical thickness in the bilateral rostral middle frontal gyrus and left superior frontal gyrus was lower in the patients with NMOSD than in the control participants. Subgroup analysis of the patients with NMOSD indicated that compared with those who did not have any optic neuritis episodes, those who did have such episodes exhibited noticeably thinner cortex in the bilateral cuneus, superior parietal cortex, and pericalcarine cortex. Correlation analysis indicated that cortical thickness in the bilateral rostral middle frontal gyrus was positively correlated with scores on the Digit Symbol Substitution Test and negatively correlated with scores on the Trail Making Test and the Expanded Disability Status Scale. These results are evidence that cortical thinning of the bilateral regional frontal cortex occurs in patients with NMOSD who have normal-appearing brain tissue, and that the degree of thinning is correlated with clinical disability and cognitive function. These findings will help improve our understanding of the imaging characteristics in NMOSD and their potential clinical significance. |
| first_indexed | 2024-03-12T22:10:03Z |
| format | Article |
| id | doaj.art-83dad9cf4576440587a8f1e3668ffac4 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-03-12T22:10:03Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-83dad9cf4576440587a8f1e3668ffac42023-07-23T16:11:16ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-0118112520252510.4103/1673-5374.371371Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control studyChuxin HuangYanyu LiYanjing ChenXuan LiaoHuiting ZhangZhiyuan WangJun LiuWei LuNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system. However, whether and how cortical changes occur in NMOSD with normal-appearing brain tissue, or whether any cortical changes correlate with clinical characteristics, is not completely clear. The current study recruited 43 patients with NMOSD who had normal-appearing brain tissue and 45 healthy controls matched for age, sex, and educational background from December 2020 to February 2022. A surface-based morphological analysis of high-resolution T1-weighted structural magnetic resonance images was used to calculate the cortical thickness, sulcal depth, and gyrification index. Analysis showed that cortical thickness in the bilateral rostral middle frontal gyrus and left superior frontal gyrus was lower in the patients with NMOSD than in the control participants. Subgroup analysis of the patients with NMOSD indicated that compared with those who did not have any optic neuritis episodes, those who did have such episodes exhibited noticeably thinner cortex in the bilateral cuneus, superior parietal cortex, and pericalcarine cortex. Correlation analysis indicated that cortical thickness in the bilateral rostral middle frontal gyrus was positively correlated with scores on the Digit Symbol Substitution Test and negatively correlated with scores on the Trail Making Test and the Expanded Disability Status Scale. These results are evidence that cortical thinning of the bilateral regional frontal cortex occurs in patients with NMOSD who have normal-appearing brain tissue, and that the degree of thinning is correlated with clinical disability and cognitive function. These findings will help improve our understanding of the imaging characteristics in NMOSD and their potential clinical significance.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=11;spage=2520;epage=2525;aulast=Huangcognitive function; cortical thickness; expanded disability status scale; gyrification; magnetic resonance imaging; neuromyelitis optica spectrum disorder; normal-appearing brain tissue; rostral middle frontal gyrus; sulcal depth; superior frontal gyrus |
| spellingShingle | Chuxin Huang Yanyu Li Yanjing Chen Xuan Liao Huiting Zhang Zhiyuan Wang Jun Liu Wei Lu Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control study Neural Regeneration Research cognitive function; cortical thickness; expanded disability status scale; gyrification; magnetic resonance imaging; neuromyelitis optica spectrum disorder; normal-appearing brain tissue; rostral middle frontal gyrus; sulcal depth; superior frontal gyrus |
| title | Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control study |
| title_full | Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control study |
| title_fullStr | Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control study |
| title_full_unstemmed | Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control study |
| title_short | Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue: a case-control study |
| title_sort | correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal appearing brain tissue a case control study |
| topic | cognitive function; cortical thickness; expanded disability status scale; gyrification; magnetic resonance imaging; neuromyelitis optica spectrum disorder; normal-appearing brain tissue; rostral middle frontal gyrus; sulcal depth; superior frontal gyrus |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=11;spage=2520;epage=2525;aulast=Huang |
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