Focal Uptake in the Sternum on <sup>18</sup>F-FDG-PET/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast Cancer
A woman in her 70s was diagnosed with left breast cancer and left axillary lymph node metastasis by an ultrasound-guided biopsy. <sup>18</sup>F-FDG-PET/CT showed strong FDG accumulation in the tumor in the left breast and a left axillary lymph node. Neoadjuvant chemotherapy (NAC) was adm...
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MDPI AG
2022-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/10/2308 |
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| author | Kumiko Hayashi Tomoyuki Fujioka Masatake Hara Yuichi Kumaki Goshi Oda Emi Yamaga Mio Mori Iichiroh Ohnishi Kazunori Kubota Tsuyoshi Nakagawa |
| author_facet | Kumiko Hayashi Tomoyuki Fujioka Masatake Hara Yuichi Kumaki Goshi Oda Emi Yamaga Mio Mori Iichiroh Ohnishi Kazunori Kubota Tsuyoshi Nakagawa |
| author_sort | Kumiko Hayashi |
| collection | DOAJ |
| description | A woman in her 70s was diagnosed with left breast cancer and left axillary lymph node metastasis by an ultrasound-guided biopsy. <sup>18</sup>F-FDG-PET/CT showed strong FDG accumulation in the tumor in the left breast and a left axillary lymph node. Neoadjuvant chemotherapy (NAC) was administered in combination with a G-CSF injection to prevent febrile neutropenia. The post-treatment <sup>18</sup>F-FDG-PET/CT showed the disappearance of the left breast tumor and left axillary lymph node and revealed a solitary new area of strong FDG accumulation in the sternum. To rule out the possibility of sternal metastasis, a sternal biopsy was performed at the same time as surgery, which revealed no malignant findings. Although very rare, focal uptake on <sup>18</sup>F-FDG-PET/CT performed after anticancer drug therapy with G-CSF may mimic a solitary bone metastasis. A bone biopsy may be a useful technique to avoid an immediate misdiagnosis of bone metastasis. |
| first_indexed | 2024-03-09T20:23:24Z |
| format | Article |
| id | doaj.art-83daf05ee38f42dd80650affa07499e6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:23:24Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-83daf05ee38f42dd80650affa07499e62023-11-23T23:43:02ZengMDPI AGDiagnostics2075-44182022-09-011210230810.3390/diagnostics12102308Focal Uptake in the Sternum on <sup>18</sup>F-FDG-PET/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast CancerKumiko Hayashi0Tomoyuki Fujioka1Masatake Hara2Yuichi Kumaki3Goshi Oda4Emi Yamaga5Mio Mori6Iichiroh Ohnishi7Kazunori Kubota8Tsuyoshi Nakagawa9Department of Breast Surgery, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanDepartment of Breast Surgery, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanDepartment of Breast Surgery, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanDepartment of Breast Surgery, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanDivision of Surgical Pathology, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanDepartment of Radiology, Dokkyo Medical University Saitama Medical Center, Saitama 343-8555, JapanDepartment of Breast Surgery, Tokyo Medical and Dental University Hospital, Tokyo 113-8510, JapanA woman in her 70s was diagnosed with left breast cancer and left axillary lymph node metastasis by an ultrasound-guided biopsy. <sup>18</sup>F-FDG-PET/CT showed strong FDG accumulation in the tumor in the left breast and a left axillary lymph node. Neoadjuvant chemotherapy (NAC) was administered in combination with a G-CSF injection to prevent febrile neutropenia. The post-treatment <sup>18</sup>F-FDG-PET/CT showed the disappearance of the left breast tumor and left axillary lymph node and revealed a solitary new area of strong FDG accumulation in the sternum. To rule out the possibility of sternal metastasis, a sternal biopsy was performed at the same time as surgery, which revealed no malignant findings. Although very rare, focal uptake on <sup>18</sup>F-FDG-PET/CT performed after anticancer drug therapy with G-CSF may mimic a solitary bone metastasis. A bone biopsy may be a useful technique to avoid an immediate misdiagnosis of bone metastasis.https://www.mdpi.com/2075-4418/12/10/2308<sup>18</sup>F-fluorodeoxyglucose positron-emission tomographygranulocyte colony stimulating factorbreast cancerbone marrowchemotherapy |
| spellingShingle | Kumiko Hayashi Tomoyuki Fujioka Masatake Hara Yuichi Kumaki Goshi Oda Emi Yamaga Mio Mori Iichiroh Ohnishi Kazunori Kubota Tsuyoshi Nakagawa Focal Uptake in the Sternum on <sup>18</sup>F-FDG-PET/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast Cancer Diagnostics <sup>18</sup>F-fluorodeoxyglucose positron-emission tomography granulocyte colony stimulating factor breast cancer bone marrow chemotherapy |
| title | Focal Uptake in the Sternum on <sup>18</sup>F-FDG-PET/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast Cancer |
| title_full | Focal Uptake in the Sternum on <sup>18</sup>F-FDG-PET/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast Cancer |
| title_fullStr | Focal Uptake in the Sternum on <sup>18</sup>F-FDG-PET/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast Cancer |
| title_full_unstemmed | Focal Uptake in the Sternum on <sup>18</sup>F-FDG-PET/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast Cancer |
| title_short | Focal Uptake in the Sternum on <sup>18</sup>F-FDG-PET/CT Caused by G-CSF Therapy after Chemotherapy Mimicking Bone Metastasis of Breast Cancer |
| title_sort | focal uptake in the sternum on sup 18 sup f fdg pet ct caused by g csf therapy after chemotherapy mimicking bone metastasis of breast cancer |
| topic | <sup>18</sup>F-fluorodeoxyglucose positron-emission tomography granulocyte colony stimulating factor breast cancer bone marrow chemotherapy |
| url | https://www.mdpi.com/2075-4418/12/10/2308 |
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