Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook
Gynaecological malignancy is a major challenge in women’s health worldwide. Cervical cancer (CC) is a particularly common type affecting the female reproductive system through an uncontrolled cell propagation causing cervical tissue injury in women. The advent of new technologies empowers research i...
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| Format: | Article |
| Language: | English |
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Bashkir State Medical University
2021-05-01
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| Series: | Креативная хирургия и онкология |
| Subjects: | |
| Online Access: | https://www.surgonco.ru/jour/article/view/587 |
| _version_ | 1797872355471523840 |
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| author | R. K. Minyazeva G. Y. Battalova I. V. Sakhautdinova I. R. Gilyazova |
| author_facet | R. K. Minyazeva G. Y. Battalova I. V. Sakhautdinova I. R. Gilyazova |
| author_sort | R. K. Minyazeva |
| collection | DOAJ |
| description | Gynaecological malignancy is a major challenge in women’s health worldwide. Cervical cancer (CC) is a particularly common type affecting the female reproductive system through an uncontrolled cell propagation causing cervical tissue injury in women. The advent of new technologies empowers research into the discovery and development of novel markers for early diagnosis, as well as therapy evaluation and monitoring. Despite manifold attempts to unravel the molecular mechanisms of CC, its pathogenesis remains largely unclear. The study of putative CC predictors is key to the invention of effective alleviating treatments. Systems biology enabled with high-throughput methods currently provides routes to tackle this problem. Unlike a traditional approach, it generates a wealth of data on prognostic biomarkers and therapeutic targets in cervical cancer, fuelling the search for novel high-sensitive and specific molecular markers. This approach will help improve the early diagnosis and treatment efficacy at a lower relapse rate. This review presents the currently on-stage and emerging biomarkers in cellular and molecular research into cervical cancer detection and prognosis. |
| first_indexed | 2024-04-10T00:58:32Z |
| format | Article |
| id | doaj.art-83dcd1913d7f4590adcccf63abde3f56 |
| institution | Directory Open Access Journal |
| issn | 2307-0501 2076-3093 |
| language | English |
| last_indexed | 2024-04-10T00:58:32Z |
| publishDate | 2021-05-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj.art-83dcd1913d7f4590adcccf63abde3f562023-03-13T10:01:10ZengBashkir State Medical UniversityКреативная хирургия и онкология2307-05012076-30932021-05-0111216617310.24060/2076-3093-2021-11-2-166-173432Genomic and Proteomic Markers of Cervical Cancer: a Prospective OutlookR. K. Minyazeva0G. Y. Battalova1I. V. Sakhautdinova2I. R. Gilyazova3Башкирский государственный медицинский университетБашкирский государственный медицинский университет; Республиканский клинический онкологический диспансерБашкирский государственный медицинский университетБашкирский государственный медицинский университет; Институт биохимии и генетики Уфимского федерального научного центра РАНGynaecological malignancy is a major challenge in women’s health worldwide. Cervical cancer (CC) is a particularly common type affecting the female reproductive system through an uncontrolled cell propagation causing cervical tissue injury in women. The advent of new technologies empowers research into the discovery and development of novel markers for early diagnosis, as well as therapy evaluation and monitoring. Despite manifold attempts to unravel the molecular mechanisms of CC, its pathogenesis remains largely unclear. The study of putative CC predictors is key to the invention of effective alleviating treatments. Systems biology enabled with high-throughput methods currently provides routes to tackle this problem. Unlike a traditional approach, it generates a wealth of data on prognostic biomarkers and therapeutic targets in cervical cancer, fuelling the search for novel high-sensitive and specific molecular markers. This approach will help improve the early diagnosis and treatment efficacy at a lower relapse rate. This review presents the currently on-stage and emerging biomarkers in cellular and molecular research into cervical cancer detection and prognosis.https://www.surgonco.ru/jour/article/view/587рак шейки маткибиомаркеры новообразованийпрогнозопухолевые антигеныпредраковые состояниядисплазия шейки маткипапилломавирус |
| spellingShingle | R. K. Minyazeva G. Y. Battalova I. V. Sakhautdinova I. R. Gilyazova Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook Креативная хирургия и онкология рак шейки матки биомаркеры новообразований прогноз опухолевые антигены предраковые состояния дисплазия шейки матки папилломавирус |
| title | Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook |
| title_full | Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook |
| title_fullStr | Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook |
| title_full_unstemmed | Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook |
| title_short | Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook |
| title_sort | genomic and proteomic markers of cervical cancer a prospective outlook |
| topic | рак шейки матки биомаркеры новообразований прогноз опухолевые антигены предраковые состояния дисплазия шейки матки папилломавирус |
| url | https://www.surgonco.ru/jour/article/view/587 |
| work_keys_str_mv | AT rkminyazeva genomicandproteomicmarkersofcervicalcanceraprospectiveoutlook AT gybattalova genomicandproteomicmarkersofcervicalcanceraprospectiveoutlook AT ivsakhautdinova genomicandproteomicmarkersofcervicalcanceraprospectiveoutlook AT irgilyazova genomicandproteomicmarkersofcervicalcanceraprospectiveoutlook |