Solvatomorphism of Moxidectin
The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatom...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/16/4869 |
| _version_ | 1797522709725315072 |
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| author | Toni Grell Mauro Barbero Franco Pattarino Giovanni Battista Giovenzana Valentina Colombo |
| author_facet | Toni Grell Mauro Barbero Franco Pattarino Giovanni Battista Giovenzana Valentina Colombo |
| author_sort | Toni Grell |
| collection | DOAJ |
| description | The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient. |
| first_indexed | 2024-03-10T08:33:17Z |
| format | Article |
| id | doaj.art-83de19a87e1a42ccae654c49bb087183 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:33:17Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-83de19a87e1a42ccae654c49bb0871832023-11-22T08:53:07ZengMDPI AGMolecules1420-30492021-08-012616486910.3390/molecules26164869Solvatomorphism of MoxidectinToni Grell0Mauro Barbero1Franco Pattarino2Giovanni Battista Giovenzana3Valentina Colombo4Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, I-20133 Milano, ItalyDipartimento di Scienze del Farmaco, Università del Piemonte Orientale A. Avogadro, Largo Donegani 2/3, I-28100 Novara, ItalyDipartimento di Scienze del Farmaco, Università del Piemonte Orientale A. Avogadro, Largo Donegani 2/3, I-28100 Novara, ItalyDipartimento di Scienze del Farmaco, Università del Piemonte Orientale A. Avogadro, Largo Donegani 2/3, I-28100 Novara, ItalyDipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, I-20133 Milano, ItalyThe solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.https://www.mdpi.com/1420-3049/26/16/4869moxidectinsolvatomorphismX-ray diffractionvariable-temperature PXRD |
| spellingShingle | Toni Grell Mauro Barbero Franco Pattarino Giovanni Battista Giovenzana Valentina Colombo Solvatomorphism of Moxidectin Molecules moxidectin solvatomorphism X-ray diffraction variable-temperature PXRD |
| title | Solvatomorphism of Moxidectin |
| title_full | Solvatomorphism of Moxidectin |
| title_fullStr | Solvatomorphism of Moxidectin |
| title_full_unstemmed | Solvatomorphism of Moxidectin |
| title_short | Solvatomorphism of Moxidectin |
| title_sort | solvatomorphism of moxidectin |
| topic | moxidectin solvatomorphism X-ray diffraction variable-temperature PXRD |
| url | https://www.mdpi.com/1420-3049/26/16/4869 |
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