Design, Synthesis, In Vitro, and In Silico Insights of 5-(Substituted benzylidene)-2-phenylthiazol-4(5<i>H</i>)-one Derivatives: A Novel Class of Anti-Melanogenic Compounds

Design, Synthesis, In Vitro, and In Silico Insights of 5-(Substituted benzylidene)-2-phenylthiazol-4(5<i>H</i>)-one Derivatives: A Novel Class of Anti-Melanogenic Compounds

(<i>Z</i>)-5-Benzylidene-2-phenylthiazol-4(5<i>H</i>)-one ((<i>Z</i>)-BPT) derivatives were designed by combining the structural characteristics of two tyrosinase inhibitors. The double-bond geometry of trisubstituted alkenes, (<i>Z</i>)-BPTs <b>...

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Bibliographic Details
Main Authors: Dahye Yoon, Min Kyung Kang, Hee Jin Jung, Sultan Ullah, Jieun Lee, Yeongmu Jeong, Sang Gyun Noh, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
(<i>Z</i>)-BPT derivatives
tyrosinase
melanogenesis
kojic acid
antioxidant
in silico
Online Access:https://www.mdpi.com/1420-3049/28/8/3293

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