A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis

A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis

Summary: In metazoans, tissues experiencing proteotoxic stress induce “transcellular chaperone signaling” (TCS) that activates molecular chaperones, such as hsp-90, in distal tissues. How this form of inter-tissue communication is mediated to upregulate systemic chaperone expression and whether it c...

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Bibliographic Details
Main Authors: Daniel O’Brien, Laura M. Jones, Sarah Good, Jo Miles, M.S. Vijayabaskar, Rebecca Aston, Catrin E. Smith, David R. Westhead, Patricija van Oosten-Hawle
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471830874X

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http://www.sciencedirect.com/science/article/pii/S221112471830874X

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