The function and regulation of TET2 in innate immunity and inflammation
Abstract TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate- and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis. Mutation and dys...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-10-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13238-020-00796-6 |
| _version_ | 1797766452428668928 |
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| author | Boyi Cong Qian Zhang Xuetao Cao |
| author_facet | Boyi Cong Qian Zhang Xuetao Cao |
| author_sort | Boyi Cong |
| collection | DOAJ |
| description | Abstract TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate- and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis. Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies. Recent studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic activity. Here, we focus on the functions of TET2 in the initiation and resolution of inflammation through epigenetic regulation and signaling network. In addition, we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases, which will provide the insight to intervene in the pathological process caused by TET2 dysregulation. |
| first_indexed | 2024-03-12T20:24:31Z |
| format | Article |
| id | doaj.art-83dfd6ec58aa47fea7036e7e84542e42 |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T20:24:31Z |
| publishDate | 2020-10-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-83dfd6ec58aa47fea7036e7e84542e422023-08-02T00:35:42ZengOxford University PressProtein & Cell1674-800X1674-80182020-10-0112316517310.1007/s13238-020-00796-6The function and regulation of TET2 in innate immunity and inflammationBoyi Cong0Qian Zhang1Xuetao Cao2Laboratory of Immunity and Inflammation, College of Life Sciences, Nankai UniversityNational Key Laboratory of Medical Immunology, Institute of Immunology, Navy Military Medical UniversityLaboratory of Immunity and Inflammation, College of Life Sciences, Nankai UniversityAbstract TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate- and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis. Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies. Recent studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic activity. Here, we focus on the functions of TET2 in the initiation and resolution of inflammation through epigenetic regulation and signaling network. In addition, we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases, which will provide the insight to intervene in the pathological process caused by TET2 dysregulation.https://doi.org/10.1007/s13238-020-00796-6TET2innate immune responseDNA demethylationinflammatory resolutioninflammatory diseases |
| spellingShingle | Boyi Cong Qian Zhang Xuetao Cao The function and regulation of TET2 in innate immunity and inflammation Protein & Cell TET2 innate immune response DNA demethylation inflammatory resolution inflammatory diseases |
| title | The function and regulation of TET2 in innate immunity and inflammation |
| title_full | The function and regulation of TET2 in innate immunity and inflammation |
| title_fullStr | The function and regulation of TET2 in innate immunity and inflammation |
| title_full_unstemmed | The function and regulation of TET2 in innate immunity and inflammation |
| title_short | The function and regulation of TET2 in innate immunity and inflammation |
| title_sort | function and regulation of tet2 in innate immunity and inflammation |
| topic | TET2 innate immune response DNA demethylation inflammatory resolution inflammatory diseases |
| url | https://doi.org/10.1007/s13238-020-00796-6 |
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