Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review
Chronic recurrent and multifocal osteomyelitis (CRMO) is a nonsporadic autoinflammatory disorder. Currently, it is diagnosed based on clinical, radiologic, pathological, and longitudinal data. Numerous aspects should be highlighted due to increased knowledge in imaging and immunology. We emphasize t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.959575/full |
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| author | Consolato M. Sergi Consolato M. Sergi Consolato M. Sergi Elka Miller Dina El Demellawy Fan Shen Mingyong Zhang |
| author_facet | Consolato M. Sergi Consolato M. Sergi Consolato M. Sergi Elka Miller Dina El Demellawy Fan Shen Mingyong Zhang |
| author_sort | Consolato M. Sergi |
| collection | DOAJ |
| description | Chronic recurrent and multifocal osteomyelitis (CRMO) is a nonsporadic autoinflammatory disorder. Currently, it is diagnosed based on clinical, radiologic, pathological, and longitudinal data. Numerous aspects should be highlighted due to increased knowledge in imaging and immunology. We emphasize the use of whole-body MRI, which is a non-invasive diagnostic strategy. A literature review was carried out on longitudinal studies. Commonly, the mean age at diagnosis is 11 years, ranging between 3 and 17. The most common sites are the long bone metaphysis, particularly femoral and tibial metaphysis. In addition, the pelvis, spine, clavicle, and mandible may be involved. In long bones, the radiologic appearance can show typical structure, mixed lytic and sclerotic, sclerotic or lytic. It is frequently metaphyseal or juxta-physeal, with hyperostosis or periosteal thickening. The involvement of the vertebral skeleton is often multifocal. Therefore, whole-body MRI is essential in identifying subclinical lesions. CRMO is a polymorphic disorder in which whole-body MRI is beneficial to demonstrate subclinical edema. Vertebral collapse requires long-term monitoring. |
| first_indexed | 2024-04-13T18:46:23Z |
| format | Article |
| id | doaj.art-83e052e679a54f428c79f5730469fbf9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T18:46:23Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-83e052e679a54f428c79f5730469fbf92022-12-22T02:34:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.959575959575Chronic recurrent multifocal osteomyelitis. A narrative and pictorial reviewConsolato M. Sergi0Consolato M. Sergi1Consolato M. Sergi2Elka Miller3Dina El Demellawy4Fan Shen5Mingyong Zhang6Anatomic Pathology Division, Children’s Hospital of Eastern Ontario (CHEO), Ottawa, ON, CanadaDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, CanadaDepartment of Orthopedics, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, ChinaMedical Imaging Department, Children’s Hospital of Eastern Ontario (CHEO), University of Ottawa, Ottawa, ON, CanadaAnatomic Pathology Division, Children’s Hospital of Eastern Ontario (CHEO), Ottawa, ON, CanadaDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, CanadaDepartment of Orthopedics, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, ChinaChronic recurrent and multifocal osteomyelitis (CRMO) is a nonsporadic autoinflammatory disorder. Currently, it is diagnosed based on clinical, radiologic, pathological, and longitudinal data. Numerous aspects should be highlighted due to increased knowledge in imaging and immunology. We emphasize the use of whole-body MRI, which is a non-invasive diagnostic strategy. A literature review was carried out on longitudinal studies. Commonly, the mean age at diagnosis is 11 years, ranging between 3 and 17. The most common sites are the long bone metaphysis, particularly femoral and tibial metaphysis. In addition, the pelvis, spine, clavicle, and mandible may be involved. In long bones, the radiologic appearance can show typical structure, mixed lytic and sclerotic, sclerotic or lytic. It is frequently metaphyseal or juxta-physeal, with hyperostosis or periosteal thickening. The involvement of the vertebral skeleton is often multifocal. Therefore, whole-body MRI is essential in identifying subclinical lesions. CRMO is a polymorphic disorder in which whole-body MRI is beneficial to demonstrate subclinical edema. Vertebral collapse requires long-term monitoring.https://www.frontiersin.org/articles/10.3389/fimmu.2022.959575/fullosteomyelitischronicitymultilateralityautoinflammatorybone |
| spellingShingle | Consolato M. Sergi Consolato M. Sergi Consolato M. Sergi Elka Miller Dina El Demellawy Fan Shen Mingyong Zhang Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review Frontiers in Immunology osteomyelitis chronicity multilaterality autoinflammatory bone |
| title | Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review |
| title_full | Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review |
| title_fullStr | Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review |
| title_full_unstemmed | Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review |
| title_short | Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review |
| title_sort | chronic recurrent multifocal osteomyelitis a narrative and pictorial review |
| topic | osteomyelitis chronicity multilaterality autoinflammatory bone |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.959575/full |
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