The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD
<i>Background and objectives</i>: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, social interaction disorder, and repetitive behavior. Dysbiotic gut microbiota (GM) could be a contributing factor to the appearance of ASD, as gastr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/8/408 |
| _version_ | 1797707263356436480 |
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| author | Agustín Ernesto Martínez-González Pedro Andreo-Martínez |
| author_facet | Agustín Ernesto Martínez-González Pedro Andreo-Martínez |
| author_sort | Agustín Ernesto Martínez-González |
| collection | DOAJ |
| description | <i>Background and objectives</i>: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, social interaction disorder, and repetitive behavior. Dysbiotic gut microbiota (GM) could be a contributing factor to the appearance of ASD, as gastrointestinal (GI) symptoms are comorbidities frequently reported in ASD. As there is a lack of reviews about the role played by GM in the GI symptoms of ASD, this work aimed to carry out a systematic review of current studies comparing the GM of children with ASD and GI symptoms with those of healthy controls in the last six years. <i>Materials and Methods:</i> The systematic review was performed following the PRISMA guidelines. The databases chosen were Web of Science, Scopus, PubMed, and PsycINFO, and the keywords were (gut* OR intestine* OR bowel* OR gastrointestinal*) AND (microbiota* OR microflora* OR bacteria* OR microbiome* OR flora* OR bacterial* OR bacteria* OR microorganism* OR feces* OR stool*) AND (autistic* OR autism* OR ASD*). <i>Results</i>: A total of 16 articles were included. Ten articles performed correlations analysis between GI symptoms and ASD. Among those 10 articles, 7 found differences between the GI symptoms present in children with ASD and healthy controls. The most common GI symptom was constipation. Among the seven articles that found differences, three performed correlations analysis between GI symptoms and gut microbe abundance. <i>Candida</i>, <i>Prevotella</i>, <i>Streptococcus</i>, and <i>Veillonella</i> showed higher and lower abundance, respectively, in children with ASD and GI symptoms in more than one article. <i>Bacteroidetes</i>, <i>Firmicutes</i>, <i>Actinomyces</i>, <i>Dorea</i>, <i>Lactobacillus</i>, <i>Faecalibacterium prausnitzii</i>, and <i>Bacteroidetes</i>/<i>Firmicutes</i> ratios showed abundance discrepancies. <i>Conclusions</i>: It is still too early to draw a conclusion about the gut microbes involved in GI symptoms of ASD. Future research should consider the relationship between ASD behavior, GM, and GI symptoms in a multidisciplinary way and homogenize sample characteristics. |
| first_indexed | 2024-03-12T06:03:51Z |
| format | Article |
| id | doaj.art-83e2b3605962422ab3faa86c6845f30f |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T06:03:51Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-83e2b3605962422ab3faa86c6845f30f2023-09-03T03:49:47ZengMDPI AGMedicina1010-660X2019-07-0155840810.3390/medicina55080408medicina55080408The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASDAgustín Ernesto Martínez-González0Pedro Andreo-Martínez1Department of Developmental Psychology and Didactics, University of Alicante, 03080 Alicante, SpainDepartment of Agricultural Chemistry, Faculty of Chemistry, University of Murcia, Campus of Espinardo, 30100 Murcia, Spain<i>Background and objectives</i>: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, social interaction disorder, and repetitive behavior. Dysbiotic gut microbiota (GM) could be a contributing factor to the appearance of ASD, as gastrointestinal (GI) symptoms are comorbidities frequently reported in ASD. As there is a lack of reviews about the role played by GM in the GI symptoms of ASD, this work aimed to carry out a systematic review of current studies comparing the GM of children with ASD and GI symptoms with those of healthy controls in the last six years. <i>Materials and Methods:</i> The systematic review was performed following the PRISMA guidelines. The databases chosen were Web of Science, Scopus, PubMed, and PsycINFO, and the keywords were (gut* OR intestine* OR bowel* OR gastrointestinal*) AND (microbiota* OR microflora* OR bacteria* OR microbiome* OR flora* OR bacterial* OR bacteria* OR microorganism* OR feces* OR stool*) AND (autistic* OR autism* OR ASD*). <i>Results</i>: A total of 16 articles were included. Ten articles performed correlations analysis between GI symptoms and ASD. Among those 10 articles, 7 found differences between the GI symptoms present in children with ASD and healthy controls. The most common GI symptom was constipation. Among the seven articles that found differences, three performed correlations analysis between GI symptoms and gut microbe abundance. <i>Candida</i>, <i>Prevotella</i>, <i>Streptococcus</i>, and <i>Veillonella</i> showed higher and lower abundance, respectively, in children with ASD and GI symptoms in more than one article. <i>Bacteroidetes</i>, <i>Firmicutes</i>, <i>Actinomyces</i>, <i>Dorea</i>, <i>Lactobacillus</i>, <i>Faecalibacterium prausnitzii</i>, and <i>Bacteroidetes</i>/<i>Firmicutes</i> ratios showed abundance discrepancies. <i>Conclusions</i>: It is still too early to draw a conclusion about the gut microbes involved in GI symptoms of ASD. Future research should consider the relationship between ASD behavior, GM, and GI symptoms in a multidisciplinary way and homogenize sample characteristics.https://www.mdpi.com/1010-660X/55/8/408autismchildrengastrointestinal symptomsgut microbiotasystematic review |
| spellingShingle | Agustín Ernesto Martínez-González Pedro Andreo-Martínez The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD Medicina autism children gastrointestinal symptoms gut microbiota systematic review |
| title | The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD |
| title_full | The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD |
| title_fullStr | The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD |
| title_full_unstemmed | The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD |
| title_short | The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD |
| title_sort | role of gut microbiota in gastrointestinal symptoms of children with asd |
| topic | autism children gastrointestinal symptoms gut microbiota systematic review |
| url | https://www.mdpi.com/1010-660X/55/8/408 |
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