Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review
Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and roots, and lamina dura thickening. Since defi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/45/2/89 |
| _version_ | 1827758046115266560 |
|---|---|
| author | Zikra Alkhayal Zakia Shinwari Ameera Gaafar Ayodele Alaiya |
| author_facet | Zikra Alkhayal Zakia Shinwari Ameera Gaafar Ayodele Alaiya |
| author_sort | Zikra Alkhayal |
| collection | DOAJ |
| description | Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and roots, and lamina dura thickening. Since deficiency of carbonic anhydrase II is a major cause behind osteopetrosis, carbonic anhydrase II activators have a large number of applications in osteopetrosis treatment. There is a lack of a comprehensive review on osteopetrosis, pathogenesis of dental abnormalities, and the role of carbonic anhydrase II activators in osteopetrosis treatment. To address this research gap, the authros perfomed a comprehensive review on osteopetrosis and its types, pathogenesis of dental abnormalities, and the role of carbonic anhydrase II activators in osteopetrosis treatment. A brief introduction to the pathogenesis of dental abnormalities and regeneration is provided in this survey. A discussion of types of osteopetrosis depending on genetic inheritance, such as autosomal dominant, autosomal recessive, and X-linked inheritance osteopetrosis, is presented in this survey. The paper also focuses on the importance of carbonic anhydrase II activators as a potential drug therapy for dental osteopetrosis. In addition, a brief note on the role of azole and fluconazole in treating osteopetrosis is given. Finally, future directions involving gene therapy for dental osteopetrosis are described. |
| first_indexed | 2024-03-11T08:59:04Z |
| format | Article |
| id | doaj.art-83e412c666984e82a9ceffc10af1f674 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T08:59:04Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-83e412c666984e82a9ceffc10af1f6742023-11-16T19:50:57ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-02-014521373138610.3390/cimb45020089Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A ReviewZikra Alkhayal0Zakia Shinwari1Ameera Gaafar2Ayodele Alaiya3Therapeutics & Biomarker Discovery for Clinical Applications, Stem Cell & Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaTherapeutics & Biomarker Discovery for Clinical Applications, Stem Cell & Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaTherapeutics & Biomarker Discovery for Clinical Applications, Stem Cell & Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaTherapeutics & Biomarker Discovery for Clinical Applications, Stem Cell & Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaOsteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and roots, and lamina dura thickening. Since deficiency of carbonic anhydrase II is a major cause behind osteopetrosis, carbonic anhydrase II activators have a large number of applications in osteopetrosis treatment. There is a lack of a comprehensive review on osteopetrosis, pathogenesis of dental abnormalities, and the role of carbonic anhydrase II activators in osteopetrosis treatment. To address this research gap, the authros perfomed a comprehensive review on osteopetrosis and its types, pathogenesis of dental abnormalities, and the role of carbonic anhydrase II activators in osteopetrosis treatment. A brief introduction to the pathogenesis of dental abnormalities and regeneration is provided in this survey. A discussion of types of osteopetrosis depending on genetic inheritance, such as autosomal dominant, autosomal recessive, and X-linked inheritance osteopetrosis, is presented in this survey. The paper also focuses on the importance of carbonic anhydrase II activators as a potential drug therapy for dental osteopetrosis. In addition, a brief note on the role of azole and fluconazole in treating osteopetrosis is given. Finally, future directions involving gene therapy for dental osteopetrosis are described.https://www.mdpi.com/1467-3045/45/2/89osteopetrosiscarbonic anhydrase II activatorsdental abnormalitiesosteoclastsazolefluconazole |
| spellingShingle | Zikra Alkhayal Zakia Shinwari Ameera Gaafar Ayodele Alaiya Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review Current Issues in Molecular Biology osteopetrosis carbonic anhydrase II activators dental abnormalities osteoclasts azole fluconazole |
| title | Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review |
| title_full | Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review |
| title_fullStr | Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review |
| title_full_unstemmed | Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review |
| title_short | Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review |
| title_sort | carbonic anhydrase ii activators in osteopetrosis treatment a review |
| topic | osteopetrosis carbonic anhydrase II activators dental abnormalities osteoclasts azole fluconazole |
| url | https://www.mdpi.com/1467-3045/45/2/89 |
| work_keys_str_mv | AT zikraalkhayal carbonicanhydraseiiactivatorsinosteopetrosistreatmentareview AT zakiashinwari carbonicanhydraseiiactivatorsinosteopetrosistreatmentareview AT ameeragaafar carbonicanhydraseiiactivatorsinosteopetrosistreatmentareview AT ayodelealaiya carbonicanhydraseiiactivatorsinosteopetrosistreatmentareview |