The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farms
IntroductionIndonesia has a large broiler industry with extensive antimicrobial use (AMU) according to empirical evidence. However, there are no quantitative data of on-farm AMU. Quantification of AMU at farm level is crucial to guide interventions on antimicrobial stewardship (AMS). The objective o...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1092302/full |
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| author | Rianna Anwar Sani Jaap A. Wagenaar Jaap A. Wagenaar Jaap A. Wagenaar Tagrid E. H. A. Dinar Sunandar Sunandar Nofita Nurbiyanti Imron Suandy Gian Pertela Elvina J. Jahja Budi Purwanto CORNERSTONE group Ingeborg M. van Geijlswijk David C. Speksnijder David C. Speksnijder David C. Speksnijder Tri S. Purwanto Muhammad A. Bagaskara Annisa Rachmawati Rangga Putra Hannan Daradjat Patricia Noreva Riana A. Arief Erianto Nugroho |
| author_facet | Rianna Anwar Sani Jaap A. Wagenaar Jaap A. Wagenaar Jaap A. Wagenaar Tagrid E. H. A. Dinar Sunandar Sunandar Nofita Nurbiyanti Imron Suandy Gian Pertela Elvina J. Jahja Budi Purwanto CORNERSTONE group Ingeborg M. van Geijlswijk David C. Speksnijder David C. Speksnijder David C. Speksnijder Tri S. Purwanto Muhammad A. Bagaskara Annisa Rachmawati Rangga Putra Hannan Daradjat Patricia Noreva Riana A. Arief Erianto Nugroho |
| author_sort | Rianna Anwar Sani |
| collection | DOAJ |
| description | IntroductionIndonesia has a large broiler industry with extensive antimicrobial use (AMU) according to empirical evidence. However, there are no quantitative data of on-farm AMU. Quantification of AMU at farm level is crucial to guide interventions on antimicrobial stewardship (AMS). The objective of this study was to compare on-farm AMU monitoring methods, to assess which monitoring method is best suited to gain insight in the quantitative AMU at farm level in medium-scale Indonesian broiler farms.MethodAMU was calculated using four different indicators—mg/PCU (mass-based), TFUDDindo (Treatment Frequency of Used Daily Dose, dose-based), TFDDDvet (Treatment Frequency of Defined Daily Dose, dose-based), and TFcount − based (count-based)—for the total AMU of 98 production cycles with an average length of 30 days.ResultsBroilers were exposed to an average of 10 days of antimicrobial treatments per production cycle, whereas 60.8% of the antimicrobials belonged to the Highest Priority Critically Important Antimicrobials (HPCIAs). For each pair of indicators, the Spearman rank correlation coefficient was calculated to assess if the production cycles were ranked consistently in increasing AMU across the different indicators. The correlation varied between 0.4 and 0.8.DiscussionThis study illustrates the considerable difference in the ranking of AMU between the different indicators. In a setting comparable to medium-scale broiler farms in Indonesia, where resources are scarce and there is no professional oversight, the TFcount − based method is best suitable. Before implementing an AMU monitoring method, careful consideration of the use-indicators is paramount to achieve fair benchmarking. |
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| publishDate | 2023-03-01 |
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| spelling | doaj.art-83e4a92685a0466f83f338b8a6dd20ef2023-03-10T04:49:52ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-03-011010.3389/fvets.2023.10923021092302The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farmsRianna Anwar Sani0Jaap A. Wagenaar1Jaap A. Wagenaar2Jaap A. Wagenaar3Tagrid E. H. A. Dinar4Sunandar Sunandar5Nofita Nurbiyanti6Imron Suandy7Gian Pertela8Elvina J. Jahja9Budi Purwanto10CORNERSTONE groupIngeborg M. van Geijlswijk11David C. Speksnijder12David C. Speksnijder13David C. Speksnijder14Tri S. PurwantoMuhammad A. BagaskaraAnnisa RachmawatiRangga PutraHannan DaradjatPatricia NorevaRiana A. AriefErianto NugrohoDivision of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, NetherlandsDivision of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, NetherlandsWageningen Bioveterinary Research, Lelystad, NetherlandsWHO Collaborating Center for Reference and Research on Campylobacter and Antimicrobial Resistance from a One Health Perspective/WOAH Reference Laboratory for Campylobacteriosis, Utrecht, NetherlandsDivision of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, NetherlandsCenter for Indonesian Veterinary Analytical Studies (CIVAS), Bogor, IndonesiaCenter for Indonesian Veterinary Analytical Studies (CIVAS), Bogor, IndonesiaMinistry of Agriculture of the Republic of Indonesia, Jakarta, IndonesiaLaboratory Services and Surveillance Department, PT Medion Farma Jaya, Bandung, IndonesiaAnimal Health Department, PT Medion Farma Jaya, Bandung, IndonesiaTechnical Education and Consultation Department, PT Medion Ardhika Bhakti, Bandung, IndonesiaDepartment of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, NetherlandsDivision of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, NetherlandsWHO Collaborating Center for Reference and Research on Campylobacter and Antimicrobial Resistance from a One Health Perspective/WOAH Reference Laboratory for Campylobacteriosis, Utrecht, Netherlands0University Farm Animal Clinic, Harmelen, NetherlandsIntroductionIndonesia has a large broiler industry with extensive antimicrobial use (AMU) according to empirical evidence. However, there are no quantitative data of on-farm AMU. Quantification of AMU at farm level is crucial to guide interventions on antimicrobial stewardship (AMS). The objective of this study was to compare on-farm AMU monitoring methods, to assess which monitoring method is best suited to gain insight in the quantitative AMU at farm level in medium-scale Indonesian broiler farms.MethodAMU was calculated using four different indicators—mg/PCU (mass-based), TFUDDindo (Treatment Frequency of Used Daily Dose, dose-based), TFDDDvet (Treatment Frequency of Defined Daily Dose, dose-based), and TFcount − based (count-based)—for the total AMU of 98 production cycles with an average length of 30 days.ResultsBroilers were exposed to an average of 10 days of antimicrobial treatments per production cycle, whereas 60.8% of the antimicrobials belonged to the Highest Priority Critically Important Antimicrobials (HPCIAs). For each pair of indicators, the Spearman rank correlation coefficient was calculated to assess if the production cycles were ranked consistently in increasing AMU across the different indicators. The correlation varied between 0.4 and 0.8.DiscussionThis study illustrates the considerable difference in the ranking of AMU between the different indicators. In a setting comparable to medium-scale broiler farms in Indonesia, where resources are scarce and there is no professional oversight, the TFcount − based method is best suitable. Before implementing an AMU monitoring method, careful consideration of the use-indicators is paramount to achieve fair benchmarking.https://www.frontiersin.org/articles/10.3389/fvets.2023.1092302/fullantimicrobial resistanceantimicrobial stewardshipveterinary antimicrobial use monitoringpoultryIndonesia |
| spellingShingle | Rianna Anwar Sani Jaap A. Wagenaar Jaap A. Wagenaar Jaap A. Wagenaar Tagrid E. H. A. Dinar Sunandar Sunandar Nofita Nurbiyanti Imron Suandy Gian Pertela Elvina J. Jahja Budi Purwanto CORNERSTONE group Ingeborg M. van Geijlswijk David C. Speksnijder David C. Speksnijder David C. Speksnijder Tri S. Purwanto Muhammad A. Bagaskara Annisa Rachmawati Rangga Putra Hannan Daradjat Patricia Noreva Riana A. Arief Erianto Nugroho The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farms Frontiers in Veterinary Science antimicrobial resistance antimicrobial stewardship veterinary antimicrobial use monitoring poultry Indonesia |
| title | The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farms |
| title_full | The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farms |
| title_fullStr | The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farms |
| title_full_unstemmed | The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farms |
| title_short | The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farms |
| title_sort | comparison and use of tools for quantification of antimicrobial use in indonesian broiler farms |
| topic | antimicrobial resistance antimicrobial stewardship veterinary antimicrobial use monitoring poultry Indonesia |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1092302/full |
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