Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate

Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate

Metronidazole (MTZ) is an antibacterial drug widely used for the treatment of protozoan and anaerobic infections in humans and animals. However, its low bioavailability necessitates the frequent administration of a high dose to attain an effective plasma concentration profile for therapy. To reduce...

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Bibliographic Details
Main Authors:	Jinhui Li, Xinghui Hao, Chenguang Wang, Haiyan Liu, Lianchao Liu, Xin He, Changquan Calvin Sun
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Pharmaceutics
Subjects:	metronidazole ethyl gallate cocrystal solubility dissolution pharmacokinetics
Online Access:	https://www.mdpi.com/1999-4923/13/4/546

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