Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation
Bacteria in the oral cavity, including commensals and opportunistic pathogens, are organized into highly specialized sessile communities, coexisting in homeostasis with the host under healthy conditions. A dysbiotic environment during biofilm evolution, however, allows opportunistic pathogens to bec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/7/880 |
| _version_ | 1797407776495894528 |
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| author | Paola Hernández María C. Sánchez Arancha Llama-Palacios María J. Ciudad Luis Collado |
| author_facet | Paola Hernández María C. Sánchez Arancha Llama-Palacios María J. Ciudad Luis Collado |
| author_sort | Paola Hernández |
| collection | DOAJ |
| description | Bacteria in the oral cavity, including commensals and opportunistic pathogens, are organized into highly specialized sessile communities, coexisting in homeostasis with the host under healthy conditions. A dysbiotic environment during biofilm evolution, however, allows opportunistic pathogens to become the dominant species at caries-affected sites at the expense of health-associated taxa. Combining tooth brushing with dentifrices or rinses combat the onset of caries by partially removes plaque, but resulting in the biofilm remaining in an immature state with undesirables’ consequences on homeostasis and oral ecosystem. This leads to the need for therapeutic pathways that focus on preserving balance in the oral microbiota and applying strategies to combat caries by maintaining biofilm integrity and homeostasis during the rapid phase of supragingival plaque formation. Adhesion, nutrition, and communication are fundamental in this phase in which the bacteria that have survived these adverse conditions rebuild and reorganize the biofilm, and are considered targets for designing preventive strategies to guide the biofilm towards a composition compatible with health. The present review summarizes the most important advances and future prospects for therapies based on the maintenance of biofilm integrity and homeostasis as a preventive measure of dysbiosis focused on these three key factors during the rapid phase of plaque formation. |
| first_indexed | 2024-03-09T03:47:28Z |
| format | Article |
| id | doaj.art-83e619c9160840708aac88699301d29b |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T03:47:28Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-83e619c9160840708aac88699301d29b2023-12-03T14:32:41ZengMDPI AGAntibiotics2079-63822022-06-0111788010.3390/antibiotics11070880Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque FormationPaola Hernández0María C. Sánchez1Arancha Llama-Palacios2María J. Ciudad3Luis Collado4Department of Medicine, Faculty of Medicine, University Complutense, 28040 Madrid, SpainDepartment of Medicine, Faculty of Medicine, University Complutense, 28040 Madrid, SpainDepartment of Medicine, Faculty of Medicine, University Complutense, 28040 Madrid, SpainDepartment of Medicine, Faculty of Medicine, University Complutense, 28040 Madrid, SpainDepartment of Medicine, Faculty of Medicine, University Complutense, 28040 Madrid, SpainBacteria in the oral cavity, including commensals and opportunistic pathogens, are organized into highly specialized sessile communities, coexisting in homeostasis with the host under healthy conditions. A dysbiotic environment during biofilm evolution, however, allows opportunistic pathogens to become the dominant species at caries-affected sites at the expense of health-associated taxa. Combining tooth brushing with dentifrices or rinses combat the onset of caries by partially removes plaque, but resulting in the biofilm remaining in an immature state with undesirables’ consequences on homeostasis and oral ecosystem. This leads to the need for therapeutic pathways that focus on preserving balance in the oral microbiota and applying strategies to combat caries by maintaining biofilm integrity and homeostasis during the rapid phase of supragingival plaque formation. Adhesion, nutrition, and communication are fundamental in this phase in which the bacteria that have survived these adverse conditions rebuild and reorganize the biofilm, and are considered targets for designing preventive strategies to guide the biofilm towards a composition compatible with health. The present review summarizes the most important advances and future prospects for therapies based on the maintenance of biofilm integrity and homeostasis as a preventive measure of dysbiosis focused on these three key factors during the rapid phase of plaque formation.https://www.mdpi.com/2079-6382/11/7/880oral biofilmdental plaquedental carieshomeostasisdysbiosisanticaries therapeutic approaches |
| spellingShingle | Paola Hernández María C. Sánchez Arancha Llama-Palacios María J. Ciudad Luis Collado Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation Antibiotics oral biofilm dental plaque dental caries homeostasis dysbiosis anticaries therapeutic approaches |
| title | Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation |
| title_full | Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation |
| title_fullStr | Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation |
| title_full_unstemmed | Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation |
| title_short | Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation |
| title_sort | strategies to combat caries by maintaining the integrity of biofilm and homeostasis during the rapid phase of supragingival plaque formation |
| topic | oral biofilm dental plaque dental caries homeostasis dysbiosis anticaries therapeutic approaches |
| url | https://www.mdpi.com/2079-6382/11/7/880 |
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