Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia
Interleukin-7 receptor alpha (IL7Ra) is important for lymphoid cell development but its role in leukaemogenesis is not clear. Here, the authors generate a knock-in murine model to show that activating mutations in IL7Ra can initiate precursor B-cell acute lymphoblastic leukaemia.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27197-5 |
| _version_ | 1818873518233747456 |
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| author | Afonso R. M. Almeida João L. Neto Ana Cachucho Mayara Euzébio Xiangyu Meng Rathana Kim Marta B. Fernandes Beatriz Raposo Mariana L. Oliveira Daniel Ribeiro Rita Fragoso Priscila P. Zenatti Tiago Soares Mafalda R. de Matos Juliana Ronchi Corrêa Mafalda Duque Kathryn G. Roberts Zhaohui Gu Chunxu Qu Clara Pereira Susan Pyne Nigel J. Pyne Vasco M. Barreto Isabelle Bernard-Pierrot Emannuelle Clappier Charles G. Mullighan Ana R. Grosso J. Andrés Yunes João T. Barata |
| author_facet | Afonso R. M. Almeida João L. Neto Ana Cachucho Mayara Euzébio Xiangyu Meng Rathana Kim Marta B. Fernandes Beatriz Raposo Mariana L. Oliveira Daniel Ribeiro Rita Fragoso Priscila P. Zenatti Tiago Soares Mafalda R. de Matos Juliana Ronchi Corrêa Mafalda Duque Kathryn G. Roberts Zhaohui Gu Chunxu Qu Clara Pereira Susan Pyne Nigel J. Pyne Vasco M. Barreto Isabelle Bernard-Pierrot Emannuelle Clappier Charles G. Mullighan Ana R. Grosso J. Andrés Yunes João T. Barata |
| author_sort | Afonso R. M. Almeida |
| collection | DOAJ |
| description | Interleukin-7 receptor alpha (IL7Ra) is important for lymphoid cell development but its role in leukaemogenesis is not clear. Here, the authors generate a knock-in murine model to show that activating mutations in IL7Ra can initiate precursor B-cell acute lymphoblastic leukaemia. |
| first_indexed | 2024-12-19T12:55:59Z |
| format | Article |
| id | doaj.art-83e6d6932423405685472917e2af4d77 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T12:55:59Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-83e6d6932423405685472917e2af4d772022-12-21T20:20:24ZengNature PortfolioNature Communications2041-17232021-12-0112111610.1038/s41467-021-27197-5Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemiaAfonso R. M. Almeida0João L. Neto1Ana Cachucho2Mayara Euzébio3Xiangyu Meng4Rathana Kim5Marta B. Fernandes6Beatriz Raposo7Mariana L. Oliveira8Daniel Ribeiro9Rita Fragoso10Priscila P. Zenatti11Tiago Soares12Mafalda R. de Matos13Juliana Ronchi Corrêa14Mafalda Duque15Kathryn G. Roberts16Zhaohui Gu17Chunxu Qu18Clara Pereira19Susan Pyne20Nigel J. Pyne21Vasco M. Barreto22Isabelle Bernard-Pierrot23Emannuelle Clappier24Charles G. Mullighan25Ana R. Grosso26J. Andrés Yunes27João T. Barata28Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstitut Curie, PSL Research University, CNRS, UMR144, Equipe Labellisée Ligue contre le CancerHematology Laboratory, Saint-Louis Hospital, AP-HP, Paris, France, and Saint-Louis Research Institute, Université de Paris, INSERM U944/Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7212Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaCentro Infantil BoldriniInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaCentro Infantil BoldriniInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaDepartment of Pathology and Hematological Malignancies Program, St. Jude Children’s Research HospitalDepartment of Pathology and Hematological Malignancies Program, St. Jude Children’s Research HospitalDepartment of Pathology and Hematological Malignancies Program, St. Jude Children’s Research HospitalSmurfit Institute of Genetics, Trinity College Dublin, University of DublinStrathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of StrathclydeStrathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of StrathclydeDNA Breaks Laboratory, CEDOC - Chronic Diseases Research Center, NOVA Medical School - Faculdade de Ciências Médicas, Universidade NOVA de LisboaInstitut Curie, PSL Research University, CNRS, UMR144, Equipe Labellisée Ligue contre le CancerHematology Laboratory, Saint-Louis Hospital, AP-HP, Paris, France, and Saint-Louis Research Institute, Université de Paris, INSERM U944/Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7212Department of Pathology and Hematological Malignancies Program, St. Jude Children’s Research HospitalUCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de LisboaCentro Infantil BoldriniInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInterleukin-7 receptor alpha (IL7Ra) is important for lymphoid cell development but its role in leukaemogenesis is not clear. Here, the authors generate a knock-in murine model to show that activating mutations in IL7Ra can initiate precursor B-cell acute lymphoblastic leukaemia.https://doi.org/10.1038/s41467-021-27197-5 |
| spellingShingle | Afonso R. M. Almeida João L. Neto Ana Cachucho Mayara Euzébio Xiangyu Meng Rathana Kim Marta B. Fernandes Beatriz Raposo Mariana L. Oliveira Daniel Ribeiro Rita Fragoso Priscila P. Zenatti Tiago Soares Mafalda R. de Matos Juliana Ronchi Corrêa Mafalda Duque Kathryn G. Roberts Zhaohui Gu Chunxu Qu Clara Pereira Susan Pyne Nigel J. Pyne Vasco M. Barreto Isabelle Bernard-Pierrot Emannuelle Clappier Charles G. Mullighan Ana R. Grosso J. Andrés Yunes João T. Barata Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia Nature Communications |
| title | Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia |
| title_full | Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia |
| title_fullStr | Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia |
| title_full_unstemmed | Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia |
| title_short | Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia |
| title_sort | interleukin 7 receptor α mutational activation can initiate precursor b cell acute lymphoblastic leukemia |
| url | https://doi.org/10.1038/s41467-021-27197-5 |
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