The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study
Background: Increasing evidence suggests that the airway microbiome plays an important role in chronic obstructive pulmonary disease (COPD). While oral bacterial lysates were found to reduce the number of acute exacerbations of COPD (AECOPD), little is known regarding the effects of bacterial lysate...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Medicine in Microecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097822000179 |
| _version_ | 1811212051803013120 |
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| author | Yafei Qi Zhou Zhu Xiaomin Liu Junhao Yang Weimin Zhang Jinlun Huang Hong Li Weijie Guan Zhang Wang Yinhuan Li |
| author_facet | Yafei Qi Zhou Zhu Xiaomin Liu Junhao Yang Weimin Zhang Jinlun Huang Hong Li Weijie Guan Zhang Wang Yinhuan Li |
| author_sort | Yafei Qi |
| collection | DOAJ |
| description | Background: Increasing evidence suggests that the airway microbiome plays an important role in chronic obstructive pulmonary disease (COPD). While oral bacterial lysates were found to reduce the number of acute exacerbations of COPD (AECOPD), little is known regarding the effects of bacterial lysates on COPD airway microbiome. Methods: Sixteen patients with AECOPD were enrolled in this pilot, prospective study from November 2020 to June 2021. Patients were randomly divided into two groups to receive conventional treatment (n = 8) or conventional treatment combined with bacterial lysates (n = 8), respectively. Sputum samples were collected upon hospital admission and at discharge. Patients were followed-up over 6 months after discharge. Results: The α-diversity was not significantly different pre- and post-treatment between the two treatment groups. There was a significantly greater weighted UniFrac distance between the paired pre- and post-treatment samples for patients receiving bacterial lysates compared to those receiving conventional treatment (P = 0.021). Among all taxa, a significantly decrease of Pseudomonadaceae was observed for patients receiving bacterial lysates group, while this trend was non-significant for the conventional treatment group. The frequency of acute exacerbations during the 6-month follow-up period was significantly lower for patients receiving bacterial lysates compared to those receiving conventional treatment (P = 0.042). Conclusions: Bacterial lysates resulted in greater alteration of the airway microbiota compared to conventional treatment. Pseudomonadaceae was significantly decreased in sputum samples of patients receiving bacterial lysate, which may be a microbiome-related mechanism by which bacterial lysates reduce COPD exacerbations. |
| first_indexed | 2024-04-12T05:22:41Z |
| format | Article |
| id | doaj.art-83e97f4960ad44bd84a42cc99c2c850b |
| institution | Directory Open Access Journal |
| issn | 2590-0978 |
| language | English |
| last_indexed | 2024-04-12T05:22:41Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Microecology |
| spelling | doaj.art-83e97f4960ad44bd84a42cc99c2c850b2022-12-22T03:46:24ZengElsevierMedicine in Microecology2590-09782022-12-0114100067The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot studyYafei Qi0Zhou Zhu1Xiaomin Liu2Junhao Yang3Weimin Zhang4Jinlun Huang5Hong Li6Weijie Guan7Zhang Wang8Yinhuan Li9Pulmonary and Critical Care Medicine, Panyu Central Hospital of Panyu District, Guangzhou, 511400, ChinaPulmonary and Critical Care Medicine, Panyu Central Hospital of Panyu District, Guangzhou, 511400, China; Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, ChinaInstitute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, ChinaInstitute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, ChinaPulmonary and Critical Care Medicine, Panyu Central Hospital of Panyu District, Guangzhou, 511400, ChinaPulmonary and Critical Care Medicine, Panyu Central Hospital of Panyu District, Guangzhou, 511400, ChinaPulmonary and Critical Care Medicine, Panyu Central Hospital of Panyu District, Guangzhou, 511400, ChinaGuanzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, ChinaPulmonary and Critical Care Medicine, Panyu Central Hospital of Panyu District, Guangzhou, 511400, China; Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, ChinaPulmonary and Critical Care Medicine, Panyu Central Hospital of Panyu District, Guangzhou, 511400, China; Corresponding author.Background: Increasing evidence suggests that the airway microbiome plays an important role in chronic obstructive pulmonary disease (COPD). While oral bacterial lysates were found to reduce the number of acute exacerbations of COPD (AECOPD), little is known regarding the effects of bacterial lysates on COPD airway microbiome. Methods: Sixteen patients with AECOPD were enrolled in this pilot, prospective study from November 2020 to June 2021. Patients were randomly divided into two groups to receive conventional treatment (n = 8) or conventional treatment combined with bacterial lysates (n = 8), respectively. Sputum samples were collected upon hospital admission and at discharge. Patients were followed-up over 6 months after discharge. Results: The α-diversity was not significantly different pre- and post-treatment between the two treatment groups. There was a significantly greater weighted UniFrac distance between the paired pre- and post-treatment samples for patients receiving bacterial lysates compared to those receiving conventional treatment (P = 0.021). Among all taxa, a significantly decrease of Pseudomonadaceae was observed for patients receiving bacterial lysates group, while this trend was non-significant for the conventional treatment group. The frequency of acute exacerbations during the 6-month follow-up period was significantly lower for patients receiving bacterial lysates compared to those receiving conventional treatment (P = 0.042). Conclusions: Bacterial lysates resulted in greater alteration of the airway microbiota compared to conventional treatment. Pseudomonadaceae was significantly decreased in sputum samples of patients receiving bacterial lysate, which may be a microbiome-related mechanism by which bacterial lysates reduce COPD exacerbations.http://www.sciencedirect.com/science/article/pii/S2590097822000179COPDBacterial lysateRespiratory microbiome16S rRna |
| spellingShingle | Yafei Qi Zhou Zhu Xiaomin Liu Junhao Yang Weimin Zhang Jinlun Huang Hong Li Weijie Guan Zhang Wang Yinhuan Li The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study Medicine in Microecology COPD Bacterial lysate Respiratory microbiome 16S rRna |
| title | The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study |
| title_full | The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study |
| title_fullStr | The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study |
| title_full_unstemmed | The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study |
| title_short | The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study |
| title_sort | effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations a pilot study |
| topic | COPD Bacterial lysate Respiratory microbiome 16S rRna |
| url | http://www.sciencedirect.com/science/article/pii/S2590097822000179 |
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