Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case–control study
Abstract Background Oxidative stress has a significant influence in the initiation and progression of epileptic seizures. It was reported that inhibiting oxidative stress could protect against epilepsy. The aim of the current research is to estimate some biomarkers that reflect the oxidative stress...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-05-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-022-00479-5 |
| _version_ | 1828202675730120704 |
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| author | Nahed Shehta Amr Elsayed Kamel Eman Sobhy Mohamed Hamdy Ismail |
| author_facet | Nahed Shehta Amr Elsayed Kamel Eman Sobhy Mohamed Hamdy Ismail |
| author_sort | Nahed Shehta |
| collection | DOAJ |
| description | Abstract Background Oxidative stress has a significant influence in the initiation and progression of epileptic seizures. It was reported that inhibiting oxidative stress could protect against epilepsy. The aim of the current research is to estimate some biomarkers that reflect the oxidative stress in epileptics, its relation to seizure control as well as to study the impact of antiepileptic drugs (AEDs) on these biomarkers. This case–control study included 62 epileptic patients beside 62 age and gender-matched healthy controls. The epileptic patients subjected to detailed history taking with special regards to disease duration, seizure frequency, and the current AEDs. Laboratory evaluation of serum malondialdehyde (a lipid peroxidation byproduct) and superoxide dismutase (an endogenous antioxidant) were done. Results Malondialdehyde (MDA) was significantly higher, and superoxide dismutase (SOD) was lower in epileptic patients than in the controls (p < 0.001). Seizure frequency was directly correlated with MDA (r = 0.584, p < 0.001) while inversely correlated with SOD (r = − 0.432, p = 0.008). High MDA and low SOD were recorded in epileptic patients receiving polytherapy as compared to monotherapy (p < 0.001). Conclusions Epileptic patients had higher oxidative stress biomarkers than healthy individuals. Frequent seizures, long disease duration, and AEDs were associated with higher MDA and lower SOD that reflects an imbalance in the oxidant–antioxidant status among these patients. |
| first_indexed | 2024-04-12T11:52:40Z |
| format | Article |
| id | doaj.art-83e9843ab9534c289e8e24180418598b |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-12T11:52:40Z |
| publishDate | 2022-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-83e9843ab9534c289e8e24180418598b2022-12-22T03:34:08ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292022-05-015811710.1186/s41983-022-00479-5Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case–control studyNahed Shehta0Amr Elsayed Kamel1Eman Sobhy2Mohamed Hamdy Ismail3Department of Neurology, Faculty of Medicine, Zagazig UniversityDepartment of Neurology, Faculty of Medicine, Zagazig UniversityDepartment of Neurology, Faculty of Medicine, Zagazig UniversityDepartment of Neurology, Faculty of Medicine, Zagazig UniversityAbstract Background Oxidative stress has a significant influence in the initiation and progression of epileptic seizures. It was reported that inhibiting oxidative stress could protect against epilepsy. The aim of the current research is to estimate some biomarkers that reflect the oxidative stress in epileptics, its relation to seizure control as well as to study the impact of antiepileptic drugs (AEDs) on these biomarkers. This case–control study included 62 epileptic patients beside 62 age and gender-matched healthy controls. The epileptic patients subjected to detailed history taking with special regards to disease duration, seizure frequency, and the current AEDs. Laboratory evaluation of serum malondialdehyde (a lipid peroxidation byproduct) and superoxide dismutase (an endogenous antioxidant) were done. Results Malondialdehyde (MDA) was significantly higher, and superoxide dismutase (SOD) was lower in epileptic patients than in the controls (p < 0.001). Seizure frequency was directly correlated with MDA (r = 0.584, p < 0.001) while inversely correlated with SOD (r = − 0.432, p = 0.008). High MDA and low SOD were recorded in epileptic patients receiving polytherapy as compared to monotherapy (p < 0.001). Conclusions Epileptic patients had higher oxidative stress biomarkers than healthy individuals. Frequent seizures, long disease duration, and AEDs were associated with higher MDA and lower SOD that reflects an imbalance in the oxidant–antioxidant status among these patients.https://doi.org/10.1186/s41983-022-00479-5Oxidative stressMalondialdehydeSuperoxide dismutaseEpilepsyAntiepileptic drugs |
| spellingShingle | Nahed Shehta Amr Elsayed Kamel Eman Sobhy Mohamed Hamdy Ismail Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case–control study The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Oxidative stress Malondialdehyde Superoxide dismutase Epilepsy Antiepileptic drugs |
| title | Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case–control study |
| title_full | Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case–control study |
| title_fullStr | Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case–control study |
| title_full_unstemmed | Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case–control study |
| title_short | Malondialdehyde and superoxide dismutase levels in patients with epilepsy: a case–control study |
| title_sort | malondialdehyde and superoxide dismutase levels in patients with epilepsy a case control study |
| topic | Oxidative stress Malondialdehyde Superoxide dismutase Epilepsy Antiepileptic drugs |
| url | https://doi.org/10.1186/s41983-022-00479-5 |
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