New Approach to Chronic Back Pain Treatment: A Case Control Study
Background and objective: Our study compares the clinical outcome of chronic low back pain present for over six months treated with alpha-lipoic acid (ALA) + palmitoylethanolamide (PEA) and myrrh and periradicular infiltrations of oxygen-ozone under CT guide to periradicular steroidal infiltrations...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/1/73 |
| _version_ | 1797445745296539648 |
|---|---|
| author | Matteo Bonetti Dorina Lauritano Gian Maria Ottaviani Alessandro Fontana Michele Frigerio Alessio Zambello Luigi Della Gatta Mario Muto Francesco Carinci |
| author_facet | Matteo Bonetti Dorina Lauritano Gian Maria Ottaviani Alessandro Fontana Michele Frigerio Alessio Zambello Luigi Della Gatta Mario Muto Francesco Carinci |
| author_sort | Matteo Bonetti |
| collection | DOAJ |
| description | Background and objective: Our study compares the clinical outcome of chronic low back pain present for over six months treated with alpha-lipoic acid (ALA) + palmitoylethanolamide (PEA) and myrrh and periradicular infiltrations of oxygen-ozone under CT guide to periradicular steroidal infiltrations in a short (one week), medium (three months) and long-term period (six months). Methods: We enrolled 246 patients (Group A) with low back pain treated with periradicular infiltrations of oxygen-ozone under CT guide combined with 800 mg/day of ALA + 600 mg/day of PEA + 200 mg/day of myrrh orally. Group B consisted of 176 patients with low back pain treated with periradicular infiltrations of steroids. Patients were clinically monitored one week after the end of treatment, at three months, and at six months using a modified version of McNab’s method. Results: In Group A, the one-week clinical follow-up registered a complete remission of painful symptoms in 206 patients (83.7%), and this manifestation remained optimal in 191 patients at the three-month follow-up (77.6%) and in 178 at six months (72.3%). While the results were satisfactory in 28 patients (10.9%) at one week, 32 (13%) in the medium term, and 41 (16.6%) in the long term, non-significant results were found in 12 patients in the control at one week (4.6%), in 23 at three months (9.3%) and in 27 at six months (10.9%). In Group B, at the short-term follow-up we obtained an excellent clinical result in 103 patients (80.5%), while at three months 85 patients reported the persistence of clinical benefit (66.4%) and at six months, 72 (56.2%) reported the same result. The result was rated satisfactory in 11 (8.5%) and poor in 4 (3%). At the three-month follow-up, 23 (18%) reported a satisfactory result, and 20 (15.6%) had a poor result. At six months, 24 (18.8%) reported the persistence of a satisfactory result while for 32 the result was poor (25%). Conclusion: The results highlight how the treatment associated with ozone therapy and oral administration of alpha-lipoic acid + palmitoylethanolamide and myrrh can be considered a valid alternative to common therapeutic approaches in the treatment of chronic low back pain. |
| first_indexed | 2024-03-09T13:30:15Z |
| format | Article |
| id | doaj.art-83e99fc6d2bb4899b85a88d03ca59697 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:30:15Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-83e99fc6d2bb4899b85a88d03ca596972023-11-30T21:19:03ZengMDPI AGBiomedicines2227-90592022-12-011117310.3390/biomedicines11010073New Approach to Chronic Back Pain Treatment: A Case Control StudyMatteo Bonetti0Dorina Lauritano1Gian Maria Ottaviani2Alessandro Fontana3Michele Frigerio4Alessio Zambello5Luigi Della Gatta6Mario Muto7Francesco Carinci8Department of Neuroradiology, Istituto Clinico Città di Brescia, 25128 Brescia, ItalyDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, ItalyEmergency and Urgency Department, Spedali Civili di Brescia, 25123 Brescia, ItalyDepartment of Neuroradiology, Istituto Clinico Città di Brescia, 25128 Brescia, ItalyDepartment of Neuroradiology, Spedali Civili di Brescia, 25123 Brescia, ItalyAnesthesia and Pain Therapy Service, Casa di Cura Borghi, 21020 Brebbia, ItalyDepartment of Neuroradiology, Ospedale Cardarelli, 80131 Napoli, ItalyDepartment of Neuroradiology, Ospedale Cardarelli, 80131 Napoli, ItalyDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, ItalyBackground and objective: Our study compares the clinical outcome of chronic low back pain present for over six months treated with alpha-lipoic acid (ALA) + palmitoylethanolamide (PEA) and myrrh and periradicular infiltrations of oxygen-ozone under CT guide to periradicular steroidal infiltrations in a short (one week), medium (three months) and long-term period (six months). Methods: We enrolled 246 patients (Group A) with low back pain treated with periradicular infiltrations of oxygen-ozone under CT guide combined with 800 mg/day of ALA + 600 mg/day of PEA + 200 mg/day of myrrh orally. Group B consisted of 176 patients with low back pain treated with periradicular infiltrations of steroids. Patients were clinically monitored one week after the end of treatment, at three months, and at six months using a modified version of McNab’s method. Results: In Group A, the one-week clinical follow-up registered a complete remission of painful symptoms in 206 patients (83.7%), and this manifestation remained optimal in 191 patients at the three-month follow-up (77.6%) and in 178 at six months (72.3%). While the results were satisfactory in 28 patients (10.9%) at one week, 32 (13%) in the medium term, and 41 (16.6%) in the long term, non-significant results were found in 12 patients in the control at one week (4.6%), in 23 at three months (9.3%) and in 27 at six months (10.9%). In Group B, at the short-term follow-up we obtained an excellent clinical result in 103 patients (80.5%), while at three months 85 patients reported the persistence of clinical benefit (66.4%) and at six months, 72 (56.2%) reported the same result. The result was rated satisfactory in 11 (8.5%) and poor in 4 (3%). At the three-month follow-up, 23 (18%) reported a satisfactory result, and 20 (15.6%) had a poor result. At six months, 24 (18.8%) reported the persistence of a satisfactory result while for 32 the result was poor (25%). Conclusion: The results highlight how the treatment associated with ozone therapy and oral administration of alpha-lipoic acid + palmitoylethanolamide and myrrh can be considered a valid alternative to common therapeutic approaches in the treatment of chronic low back pain.https://www.mdpi.com/2227-9059/11/1/73intraforaminal infiltrationsteroidoxygen-ozonelow-back painalpha lipoic acidpalmitoylethanolamide |
| spellingShingle | Matteo Bonetti Dorina Lauritano Gian Maria Ottaviani Alessandro Fontana Michele Frigerio Alessio Zambello Luigi Della Gatta Mario Muto Francesco Carinci New Approach to Chronic Back Pain Treatment: A Case Control Study Biomedicines intraforaminal infiltration steroid oxygen-ozone low-back pain alpha lipoic acid palmitoylethanolamide |
| title | New Approach to Chronic Back Pain Treatment: A Case Control Study |
| title_full | New Approach to Chronic Back Pain Treatment: A Case Control Study |
| title_fullStr | New Approach to Chronic Back Pain Treatment: A Case Control Study |
| title_full_unstemmed | New Approach to Chronic Back Pain Treatment: A Case Control Study |
| title_short | New Approach to Chronic Back Pain Treatment: A Case Control Study |
| title_sort | new approach to chronic back pain treatment a case control study |
| topic | intraforaminal infiltration steroid oxygen-ozone low-back pain alpha lipoic acid palmitoylethanolamide |
| url | https://www.mdpi.com/2227-9059/11/1/73 |
| work_keys_str_mv | AT matteobonetti newapproachtochronicbackpaintreatmentacasecontrolstudy AT dorinalauritano newapproachtochronicbackpaintreatmentacasecontrolstudy AT gianmariaottaviani newapproachtochronicbackpaintreatmentacasecontrolstudy AT alessandrofontana newapproachtochronicbackpaintreatmentacasecontrolstudy AT michelefrigerio newapproachtochronicbackpaintreatmentacasecontrolstudy AT alessiozambello newapproachtochronicbackpaintreatmentacasecontrolstudy AT luigidellagatta newapproachtochronicbackpaintreatmentacasecontrolstudy AT mariomuto newapproachtochronicbackpaintreatmentacasecontrolstudy AT francescocarinci newapproachtochronicbackpaintreatmentacasecontrolstudy |