Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of Necrosis
This study investigates the clinical and pathological outcomes of preoperative balloon-occluded transcatheter arterial chemoembolization (B-TACE) in patients with single hepatocellular carcinoma (HCC). The data are from 25 consecutive patients who underwent sequential treatment of subsegmental B-TAC...
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MDPI AG
2023-10-01
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| Online Access: | https://www.mdpi.com/2079-9721/11/4/149 |
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| author | Jihoon Kim Dong Il Gwon Yonghun Kim Gun Ha Kim Seong Ho Kim Hee Ho Chu Jin Hyoung Kim Ji Hoon Shin Gi-Young Ko Hyun-Ki Yoon |
| author_facet | Jihoon Kim Dong Il Gwon Yonghun Kim Gun Ha Kim Seong Ho Kim Hee Ho Chu Jin Hyoung Kim Ji Hoon Shin Gi-Young Ko Hyun-Ki Yoon |
| author_sort | Jihoon Kim |
| collection | DOAJ |
| description | This study investigates the clinical and pathological outcomes of preoperative balloon-occluded transcatheter arterial chemoembolization (B-TACE) in patients with single hepatocellular carcinoma (HCC). The data are from 25 consecutive patients who underwent sequential treatment of subsegmental B-TACE and hepatic surgery for single HCC. Radiological and pathological evaluation of oily subsegmentectomy, defined as the iodized oil-laden necrotic area that includes the entire HCC and surrounding liver parenchyma, were performed. Subsegmental B-TACE was technically successful in all patients. The major and minor complication rates were 8% and 24%, respectively. On the first follow-up computed tomography (CT), oily subsegmentectomy was observed in 18 (72%) out of 25 patients. Apart from one patient showing a partial response, the remaining 24 (96%) patients showed a complete response. Pathological complete necrosis of the HCC was observed in 18 (72%) out of 25 patients with complete or extensive necrosis of the peritumoral liver parenchyma. The remaining seven patients without peritumoral parenchymal necrosis had extensive necrosis of the HCCs. In conclusion, preoperative B-TACE can be a safe and effective method for the treatment of single HCC and a good bridge treatment for subsequent surgical resection. In addition, oily subsegmentectomy itself on the CT can be a good predictor of pathological complete necrosis of the HCC. The findings obtained from this study would provide a potential role of B-TACE in the treatment strategy for single HCC. |
| first_indexed | 2024-03-08T20:50:51Z |
| format | Article |
| id | doaj.art-83ea1cd71720481eaeb1b5bac2065276 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-08T20:50:51Z |
| publishDate | 2023-10-01 |
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| record_format | Article |
| series | Diseases |
| spelling | doaj.art-83ea1cd71720481eaeb1b5bac20652762023-12-22T14:03:32ZengMDPI AGDiseases2079-97212023-10-0111414910.3390/diseases11040149Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of NecrosisJihoon Kim0Dong Il Gwon1Yonghun Kim2Gun Ha Kim3Seong Ho Kim4Hee Ho Chu5Jin Hyoung Kim6Ji Hoon Shin7Gi-Young Ko8Hyun-Ki Yoon9Department of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaDepartment of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05502, Republic of KoreaThis study investigates the clinical and pathological outcomes of preoperative balloon-occluded transcatheter arterial chemoembolization (B-TACE) in patients with single hepatocellular carcinoma (HCC). The data are from 25 consecutive patients who underwent sequential treatment of subsegmental B-TACE and hepatic surgery for single HCC. Radiological and pathological evaluation of oily subsegmentectomy, defined as the iodized oil-laden necrotic area that includes the entire HCC and surrounding liver parenchyma, were performed. Subsegmental B-TACE was technically successful in all patients. The major and minor complication rates were 8% and 24%, respectively. On the first follow-up computed tomography (CT), oily subsegmentectomy was observed in 18 (72%) out of 25 patients. Apart from one patient showing a partial response, the remaining 24 (96%) patients showed a complete response. Pathological complete necrosis of the HCC was observed in 18 (72%) out of 25 patients with complete or extensive necrosis of the peritumoral liver parenchyma. The remaining seven patients without peritumoral parenchymal necrosis had extensive necrosis of the HCCs. In conclusion, preoperative B-TACE can be a safe and effective method for the treatment of single HCC and a good bridge treatment for subsequent surgical resection. In addition, oily subsegmentectomy itself on the CT can be a good predictor of pathological complete necrosis of the HCC. The findings obtained from this study would provide a potential role of B-TACE in the treatment strategy for single HCC.https://www.mdpi.com/2079-9721/11/4/149liverhepatocellular carcinomachemoembolizationballoon occlusiontumor necrosis |
| spellingShingle | Jihoon Kim Dong Il Gwon Yonghun Kim Gun Ha Kim Seong Ho Kim Hee Ho Chu Jin Hyoung Kim Ji Hoon Shin Gi-Young Ko Hyun-Ki Yoon Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of Necrosis Diseases liver hepatocellular carcinoma chemoembolization balloon occlusion tumor necrosis |
| title | Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of Necrosis |
| title_full | Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of Necrosis |
| title_fullStr | Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of Necrosis |
| title_full_unstemmed | Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of Necrosis |
| title_short | Preoperative Balloon-Occluded Transcatheter Arterial Chemoembolization Followed by Surgical Resection: Pathological Evaluation of Necrosis |
| title_sort | preoperative balloon occluded transcatheter arterial chemoembolization followed by surgical resection pathological evaluation of necrosis |
| topic | liver hepatocellular carcinoma chemoembolization balloon occlusion tumor necrosis |
| url | https://www.mdpi.com/2079-9721/11/4/149 |
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