A cross-sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy-induced hypertensive women in the highlands western ghats of nilgiris
Background: The elevated serum iron levels and reduced platelet count at 20–24th week of gestation period cause oxidative stress that leads to the pregnancy-induced hypertension (PIH). Objectives: The objective is to determine the prevalence of serum iron concentration, decrease in platelet count, a...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Indian Journal of Community Medicine |
| Subjects: | |
| Online Access: | http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=1;spage=125;epage=129;aulast=Basutkar |
| _version_ | 1828344911299084288 |
|---|---|
| author | Roopa Satyanarayan Basutkar Bhaktraj Singh Chauhan |
| author_facet | Roopa Satyanarayan Basutkar Bhaktraj Singh Chauhan |
| author_sort | Roopa Satyanarayan Basutkar |
| collection | DOAJ |
| description | Background: The elevated serum iron levels and reduced platelet count at 20–24th week of gestation period cause oxidative stress that leads to the pregnancy-induced hypertension (PIH). Objectives: The objective is to determine the prevalence of serum iron concentration, decrease in platelet count, and its association with PIH. Methods: A cross-sectional study was conducted in the secondary care hospital of Udhagamandalam. A total of 150 study participants were enrolled. Descriptive analysis was performed for demographic characteristics. The Pearson Chi-square test was performed for categorical variables. To measure the strength of the association between the two variables, Pearson's correlation test and logistic regression analysis were performed. Results: The mean serum iron levels in both the groups were 99.01 ± 12.86 ug/dL and 82.76 ± 18.95 ug/dL, respectively, at a P value of 0.005. The platelet count (96.34 ± 9.77 vs. 116.68 ± 23.55) was significantly lower in PIH group. A moderate and weak correlation was seen between serum iron levels and systolic blood pressure (SBP) (r = 0.435; P = 0.01) and diastolic blood pressure (DBP) (r = 0.435; P = 0.01). Moderate negative correlation was observed between SBP, DBP, and platelet count. The risk of developing PIH is 6.76 times due to increased serum iron levels and 3.67 due to decreased platelet count. Conclusion: The serum iron levels were elevated, and the platelet indices were reduced in the PIH group. This should be considered a possible risk biomarker for PIH. |
| first_indexed | 2024-04-14T00:04:59Z |
| format | Article |
| id | doaj.art-83ea8b6f220449ad8a623b7e78ce740b |
| institution | Directory Open Access Journal |
| issn | 0970-0218 1998-3581 |
| language | English |
| last_indexed | 2024-04-14T00:04:59Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Community Medicine |
| spelling | doaj.art-83ea8b6f220449ad8a623b7e78ce740b2022-12-22T02:23:35ZengWolters Kluwer Medknow PublicationsIndian Journal of Community Medicine0970-02181998-35812022-01-0147112512910.4103/ijcm.ijcm_897_21A cross-sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy-induced hypertensive women in the highlands western ghats of nilgirisRoopa Satyanarayan BasutkarBhaktraj Singh ChauhanBackground: The elevated serum iron levels and reduced platelet count at 20–24th week of gestation period cause oxidative stress that leads to the pregnancy-induced hypertension (PIH). Objectives: The objective is to determine the prevalence of serum iron concentration, decrease in platelet count, and its association with PIH. Methods: A cross-sectional study was conducted in the secondary care hospital of Udhagamandalam. A total of 150 study participants were enrolled. Descriptive analysis was performed for demographic characteristics. The Pearson Chi-square test was performed for categorical variables. To measure the strength of the association between the two variables, Pearson's correlation test and logistic regression analysis were performed. Results: The mean serum iron levels in both the groups were 99.01 ± 12.86 ug/dL and 82.76 ± 18.95 ug/dL, respectively, at a P value of 0.005. The platelet count (96.34 ± 9.77 vs. 116.68 ± 23.55) was significantly lower in PIH group. A moderate and weak correlation was seen between serum iron levels and systolic blood pressure (SBP) (r = 0.435; P = 0.01) and diastolic blood pressure (DBP) (r = 0.435; P = 0.01). Moderate negative correlation was observed between SBP, DBP, and platelet count. The risk of developing PIH is 6.76 times due to increased serum iron levels and 3.67 due to decreased platelet count. Conclusion: The serum iron levels were elevated, and the platelet indices were reduced in the PIH group. This should be considered a possible risk biomarker for PIH.http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=1;spage=125;epage=129;aulast=Basutkargestational hypertensionpercent transferrinplatelet countpregnancy-induced hypertensionserum ferritinserum iron |
| spellingShingle | Roopa Satyanarayan Basutkar Bhaktraj Singh Chauhan A cross-sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy-induced hypertensive women in the highlands western ghats of nilgiris Indian Journal of Community Medicine gestational hypertension percent transferrin platelet count pregnancy-induced hypertension serum ferritin serum iron |
| title | A cross-sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy-induced hypertensive women in the highlands western ghats of nilgiris |
| title_full | A cross-sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy-induced hypertensive women in the highlands western ghats of nilgiris |
| title_fullStr | A cross-sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy-induced hypertensive women in the highlands western ghats of nilgiris |
| title_full_unstemmed | A cross-sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy-induced hypertensive women in the highlands western ghats of nilgiris |
| title_short | A cross-sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy-induced hypertensive women in the highlands western ghats of nilgiris |
| title_sort | cross sectional study investigating the association of serum iron concentration and platelet count as a risk biomarker among the pregnancy induced hypertensive women in the highlands western ghats of nilgiris |
| topic | gestational hypertension percent transferrin platelet count pregnancy-induced hypertension serum ferritin serum iron |
| url | http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=1;spage=125;epage=129;aulast=Basutkar |
| work_keys_str_mv | AT roopasatyanarayanbasutkar acrosssectionalstudyinvestigatingtheassociationofserumironconcentrationandplateletcountasariskbiomarkeramongthepregnancyinducedhypertensivewomeninthehighlandswesternghatsofnilgiris AT bhaktrajsinghchauhan acrosssectionalstudyinvestigatingtheassociationofserumironconcentrationandplateletcountasariskbiomarkeramongthepregnancyinducedhypertensivewomeninthehighlandswesternghatsofnilgiris AT roopasatyanarayanbasutkar crosssectionalstudyinvestigatingtheassociationofserumironconcentrationandplateletcountasariskbiomarkeramongthepregnancyinducedhypertensivewomeninthehighlandswesternghatsofnilgiris AT bhaktrajsinghchauhan crosssectionalstudyinvestigatingtheassociationofserumironconcentrationandplateletcountasariskbiomarkeramongthepregnancyinducedhypertensivewomeninthehighlandswesternghatsofnilgiris |