Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process
In recent years, the importance of “environmentally friendly manufacturing” has been increasing toward the establishment of a resource-recycling society. In organic synthesis, as well, it is becoming increasingly important to develop new synthetic strategies with resource conservation and the recycl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/2/787 |
| _version_ | 1797438257018961920 |
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| author | Yuki Yamamoto Akiya Ogawa |
| author_facet | Yuki Yamamoto Akiya Ogawa |
| author_sort | Yuki Yamamoto |
| collection | DOAJ |
| description | In recent years, the importance of “environmentally friendly manufacturing” has been increasing toward the establishment of a resource-recycling society. In organic synthesis, as well, it is becoming increasingly important to develop new synthetic strategies with resource conservation and the recycling of elemental resources in mind, rather than just only synthesis. Many studies on the construction of frameworks of functional molecules using ionic reactions and transition-metal-catalyzed reactions have been reported, but most of them have focused on the formation of carbon–carbon bonds. However, it is essential to introduce appropriate functional groups at appropriate positions in molecules in order for the molecules to express their functions, and furthermore, the highly selective preparation of multiple functional groups is considered important for the creation of new functional molecules. In this review, we focus on radical reactions with high functional group selectivity and overview the recent progress in practical methods for the simultaneous introduction of multiple functional groups and propose future synthetic strategies that emphasize the recycling of elemental resources and environmental friendliness. |
| first_indexed | 2024-03-09T11:35:03Z |
| format | Article |
| id | doaj.art-83eaea688b3a44a69aef3da111c3fa33 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:35:03Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-83eaea688b3a44a69aef3da111c3fa332023-11-30T23:44:53ZengMDPI AGMolecules1420-30492023-01-0128278710.3390/molecules28020787Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical ProcessYuki Yamamoto0Akiya Ogawa1Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Osaka 599-8531, JapanDepartment of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Osaka 599-8531, JapanIn recent years, the importance of “environmentally friendly manufacturing” has been increasing toward the establishment of a resource-recycling society. In organic synthesis, as well, it is becoming increasingly important to develop new synthetic strategies with resource conservation and the recycling of elemental resources in mind, rather than just only synthesis. Many studies on the construction of frameworks of functional molecules using ionic reactions and transition-metal-catalyzed reactions have been reported, but most of them have focused on the formation of carbon–carbon bonds. However, it is essential to introduce appropriate functional groups at appropriate positions in molecules in order for the molecules to express their functions, and furthermore, the highly selective preparation of multiple functional groups is considered important for the creation of new functional molecules. In this review, we focus on radical reactions with high functional group selectivity and overview the recent progress in practical methods for the simultaneous introduction of multiple functional groups and propose future synthetic strategies that emphasize the recycling of elemental resources and environmental friendliness.https://www.mdpi.com/1420-3049/28/2/787heteroatomsinterelement compoundsmetal-free conditionsradical reactionunsaturated compoundsfunctionalization |
| spellingShingle | Yuki Yamamoto Akiya Ogawa Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process Molecules heteroatoms interelement compounds metal-free conditions radical reaction unsaturated compounds functionalization |
| title | Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process |
| title_full | Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process |
| title_fullStr | Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process |
| title_full_unstemmed | Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process |
| title_short | Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process |
| title_sort | metal free one pot multi functionalization of unsaturated compounds with interelement compounds by radical process |
| topic | heteroatoms interelement compounds metal-free conditions radical reaction unsaturated compounds functionalization |
| url | https://www.mdpi.com/1420-3049/28/2/787 |
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