The <i>NF1</i>+/- Immune Microenvironment: Dueling Roles in Neurofibroma Development and Malignant Transformation

The <i>NF1</i>+/- Immune Microenvironment: Dueling Roles in Neurofibroma Development and Malignant Transformation

Neurofibromatosis type 1 (NF1) is a common genetic disorder resulting in the development of both benign and malignant tumors of the peripheral nervous system. NF1 is caused by germline pathogenic variants or deletions of the <i>NF1</i> tumor suppressor gene, which encodes the protein neu...

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Bibliographic Details
Main Authors: Emily E. White, Steven D. Rhodes
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
neurofibromatosis type 1 (NF1)
plexiform neurofibroma
atypical neurofibroma
malignant peripheral nerve sheath tumor
Schwann cells
immune microenvironment
Online Access:https://www.mdpi.com/2072-6694/16/5/994

Internet

https://www.mdpi.com/2072-6694/16/5/994

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