RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview
Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively low molecular weight and are released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs of highest amount in hum...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2020-09-01
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| Series: | Acta Medica Bulgarica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/amb-2020-0037 |
| _version_ | 1818403738913603584 |
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| author | Mihaylova Z. Ugrinov R. Aleksiev E. Stanimirov P. |
| author_facet | Mihaylova Z. Ugrinov R. Aleksiev E. Stanimirov P. |
| author_sort | Mihaylova Z. |
| collection | DOAJ |
| description | Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively low molecular weight and are released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs of highest amount in human platelets. It is known to stimulate cell proliferation and extracellular matrix synthesis, as well as angiogenesis in healthy tissues and neoplasms. However, most of the studies in the literature demonstrate the influence of PDGF on tissue regeneration without revealing its intimate mechanisms of action on different cell types. In the current review we emphasis on the effects of PDGF in order to stimulate various biological processes in wide number of pre-clinical and clinical studies. |
| first_indexed | 2024-12-14T08:29:02Z |
| format | Article |
| id | doaj.art-83f138091d4346239da3f6af68a55692 |
| institution | Directory Open Access Journal |
| issn | 0324-1750 |
| language | English |
| last_indexed | 2024-12-14T08:29:02Z |
| publishDate | 2020-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Bulgarica |
| spelling | doaj.art-83f138091d4346239da3f6af68a556922022-12-21T23:09:34ZengSciendoActa Medica Bulgarica0324-17502020-09-01473616610.2478/amb-2020-0037RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An OverviewMihaylova Z.0Ugrinov R.1Aleksiev E.2Stanimirov P.3Department of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University – Sofia, BulgariaDepartment of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University – Sofia, BulgariaDepartment of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University – Sofia, BulgariaDepartment of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University – Sofia, BulgariaGrowth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively low molecular weight and are released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs of highest amount in human platelets. It is known to stimulate cell proliferation and extracellular matrix synthesis, as well as angiogenesis in healthy tissues and neoplasms. However, most of the studies in the literature demonstrate the influence of PDGF on tissue regeneration without revealing its intimate mechanisms of action on different cell types. In the current review we emphasis on the effects of PDGF in order to stimulate various biological processes in wide number of pre-clinical and clinical studies.https://doi.org/10.2478/amb-2020-0037growth factorsplatelet-derived growth factorpdgforal surgery |
| spellingShingle | Mihaylova Z. Ugrinov R. Aleksiev E. Stanimirov P. RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview Acta Medica Bulgarica growth factors platelet-derived growth factor pdgf oral surgery |
| title | RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview |
| title_full | RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview |
| title_fullStr | RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview |
| title_full_unstemmed | RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview |
| title_short | RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview |
| title_sort | rhpdgf basic characteristics and potential application in the oral surgery an overview |
| topic | growth factors platelet-derived growth factor pdgf oral surgery |
| url | https://doi.org/10.2478/amb-2020-0037 |
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