Proteomic Biomarkers of Atherosclerosis
Biomarkers provide a powerful approach to understanding the spectrum of cardiovascular diseases. They have application in screening, diagnostic, prognostication, prediction of recurrences and monitoring of therapy. The “omics” tool are becoming very useful in the development of new biomarkers in car...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2008-01-01
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| Series: | Biomarker Insights |
| Subjects: | |
| Online Access: | http://la-press.com/article.php?article_id=608 |
| _version_ | 1818576760893079552 |
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| author | Natacha Diaz-Prieto M.G. Barderas G. Alvarez-Llamas F. de la Cuesta V.M. Darde L.R. Padial F. Vivanco |
| author_facet | Natacha Diaz-Prieto M.G. Barderas G. Alvarez-Llamas F. de la Cuesta V.M. Darde L.R. Padial F. Vivanco |
| author_sort | Natacha Diaz-Prieto |
| collection | DOAJ |
| description | Biomarkers provide a powerful approach to understanding the spectrum of cardiovascular diseases. They have application in screening, diagnostic, prognostication, prediction of recurrences and monitoring of therapy. The “omics” tool are becoming very useful in the development of new biomarkers in cardiovascular diseases. Among them, proteomics is especially fitted to look for new proteins in health and disease and is playing a significant role in the development of new diagnostic tools in cardiovascular diagnosis and prognosis. This review provides an overview of progress in applying proteomics to atherosclerosis. First, we describe novel proteins identified analysing atherosclerotic plaques directly. Careful analysis of proteins within the atherosclerotic vascular tissue can provide a repertoire of proteins involved in vascular remodelling and atherogenesis. Second, we discuss recent data concerning proteins secreted by atherosclerotic plaques. The definition of the atheroma plaque secretome resides in that proteins secreted by arteries can be very good candidates of novel biomarkers. Finally we describe proteins that have been differentially expressed (versus controls) by individual cells which constitute atheroma plaques (endothelial cells, vascular smooth muscle cells, macrophages and foam cells) as well as by circulating cells (monocytes, platelets) or novel biomarkers present in plasma. |
| first_indexed | 2024-12-16T06:19:09Z |
| format | Article |
| id | doaj.art-83f167bf690d43c79d28772a7a83edea |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-16T06:19:09Z |
| publishDate | 2008-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-83f167bf690d43c79d28772a7a83edea2022-12-21T22:41:11ZengSAGE PublishingBiomarker Insights1177-27192008-01-013101113Proteomic Biomarkers of AtherosclerosisNatacha Diaz-PrietoM.G. BarderasG. Alvarez-LlamasF. de la CuestaV.M. DardeL.R. PadialF. VivancoBiomarkers provide a powerful approach to understanding the spectrum of cardiovascular diseases. They have application in screening, diagnostic, prognostication, prediction of recurrences and monitoring of therapy. The “omics” tool are becoming very useful in the development of new biomarkers in cardiovascular diseases. Among them, proteomics is especially fitted to look for new proteins in health and disease and is playing a significant role in the development of new diagnostic tools in cardiovascular diagnosis and prognosis. This review provides an overview of progress in applying proteomics to atherosclerosis. First, we describe novel proteins identified analysing atherosclerotic plaques directly. Careful analysis of proteins within the atherosclerotic vascular tissue can provide a repertoire of proteins involved in vascular remodelling and atherogenesis. Second, we discuss recent data concerning proteins secreted by atherosclerotic plaques. The definition of the atheroma plaque secretome resides in that proteins secreted by arteries can be very good candidates of novel biomarkers. Finally we describe proteins that have been differentially expressed (versus controls) by individual cells which constitute atheroma plaques (endothelial cells, vascular smooth muscle cells, macrophages and foam cells) as well as by circulating cells (monocytes, platelets) or novel biomarkers present in plasma.http://la-press.com/article.php?article_id=608atheroma plaqueatherosclerosisbiomarkersproteomicscardiovascular diseases |
| spellingShingle | Natacha Diaz-Prieto M.G. Barderas G. Alvarez-Llamas F. de la Cuesta V.M. Darde L.R. Padial F. Vivanco Proteomic Biomarkers of Atherosclerosis Biomarker Insights atheroma plaque atherosclerosis biomarkers proteomics cardiovascular diseases |
| title | Proteomic Biomarkers of Atherosclerosis |
| title_full | Proteomic Biomarkers of Atherosclerosis |
| title_fullStr | Proteomic Biomarkers of Atherosclerosis |
| title_full_unstemmed | Proteomic Biomarkers of Atherosclerosis |
| title_short | Proteomic Biomarkers of Atherosclerosis |
| title_sort | proteomic biomarkers of atherosclerosis |
| topic | atheroma plaque atherosclerosis biomarkers proteomics cardiovascular diseases |
| url | http://la-press.com/article.php?article_id=608 |
| work_keys_str_mv | AT natachadiazprieto proteomicbiomarkersofatherosclerosis AT mgbarderas proteomicbiomarkersofatherosclerosis AT galvarezllamas proteomicbiomarkersofatherosclerosis AT fdelacuesta proteomicbiomarkersofatherosclerosis AT vmdarde proteomicbiomarkersofatherosclerosis AT lrpadial proteomicbiomarkersofatherosclerosis AT fvivanco proteomicbiomarkersofatherosclerosis |