Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants
This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their p...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/10/3/602 |
| _version_ | 1827750496321929216 |
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| author | Anna Parra-Llorca Alejandro Pinilla-Gonzlez Laura Torrejón-Rodríguez Inmaculada Lara-Cantón Julia Kuligowski María Carmen Collado María Gormaz Marta Aguar Máximo Vento Eva Serna María Cernada |
| author_facet | Anna Parra-Llorca Alejandro Pinilla-Gonzlez Laura Torrejón-Rodríguez Inmaculada Lara-Cantón Julia Kuligowski María Carmen Collado María Gormaz Marta Aguar Máximo Vento Eva Serna María Cernada |
| author_sort | Anna Parra-Llorca |
| collection | DOAJ |
| description | This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota. |
| first_indexed | 2024-03-11T06:43:51Z |
| format | Article |
| id | doaj.art-83f2b3649e36421ba0d1f9bd9405843f |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T06:43:51Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-83f2b3649e36421ba0d1f9bd9405843f2023-11-17T10:22:35ZengMDPI AGChildren2227-90672023-03-0110360210.3390/children10030602Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm InfantsAnna Parra-Llorca0Alejandro Pinilla-Gonzlez1Laura Torrejón-Rodríguez2Inmaculada Lara-Cantón3Julia Kuligowski4María Carmen Collado5María Gormaz6Marta Aguar7Máximo Vento8Eva Serna9María Cernada10Division of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, SpainDivision of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, SpainDivision of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, SpainDivision of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, SpainNeonatal Research Group, Health Research Institute La Fe (IISLAFE), 46026 Valencia, SpainDepartment of Biotechnology, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), 46980 Valencia, SpainDivision of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, SpainDivision of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, SpainDivision of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, SpainDepartment of Physiology, University of Valencia, 46010 Valencia, SpainDivision of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, SpainThis is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota.https://www.mdpi.com/2227-9067/10/3/602sepsispretermimmune responseoxidative stressmicrobiome |
| spellingShingle | Anna Parra-Llorca Alejandro Pinilla-Gonzlez Laura Torrejón-Rodríguez Inmaculada Lara-Cantón Julia Kuligowski María Carmen Collado María Gormaz Marta Aguar Máximo Vento Eva Serna María Cernada Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants Children sepsis preterm immune response oxidative stress microbiome |
| title | Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants |
| title_full | Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants |
| title_fullStr | Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants |
| title_full_unstemmed | Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants |
| title_short | Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants |
| title_sort | effects of sepsis on immune response microbiome and oxidative metabolism in preterm infants |
| topic | sepsis preterm immune response oxidative stress microbiome |
| url | https://www.mdpi.com/2227-9067/10/3/602 |
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