The Epidemiologic and Demographic Characteristics and Clinical Findings in Patients with Acute Disseminated Encephalomyelitis (ADEM) Referred to Alzahra Hospital, Isfahan, Iran, During 10 Years (2003-2013)
Background: Acute disseminated encephalomyelitis (ADEM) is an uncommon monophasic disease often with good prognosis. It is a differential diagnosis of multiple sclerosis (MS). Accurate distinction between acute disseminated encephalomyelitis and multiple sclerosis is important for prognosis and trea...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2015-09-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/5199 |
| _version_ | 1797720278973808640 |
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| author | Masoud Etemadifar Farzaneh Kadkhodaei Mohammadreza Najafi |
| author_facet | Masoud Etemadifar Farzaneh Kadkhodaei Mohammadreza Najafi |
| author_sort | Masoud Etemadifar |
| collection | DOAJ |
| description | Background: Acute disseminated encephalomyelitis (ADEM) is an uncommon monophasic disease often with good prognosis. It is a differential diagnosis of multiple sclerosis (MS). Accurate distinction between acute disseminated encephalomyelitis and multiple sclerosis is important for prognosis and treatment; as many patients with multiple sclerosis may benefit from early disease-modifying therapy to suppress ongoing and future relapses.
Methods: In a retrograde study, all the patients presented to Alzahra hospital (Isfahan, Iran) with definite diagnosis of acute disseminated encephalomyelitis during a 10-year period were included. Demographic data, clinical signs and symptoms, and laboratory and imaging findings were collected and analyzed using t and chi-square tests via SPSS software.
Findings: Forty-two patients with mean age of 20.05 ± 10.04 years and a female-predominance of 64.3% participated in the study. Thirty-three patients (78.6%) had a recent history of infectious disease. A seasonal pattern of distribution in spring (31%) and autumn (31%) was seen. The cerebrospinal fluid (CSF) analysis findings showed pleocytosis and increased protein in 26 (61.9%) and 25 (59.6%) cases, respectively. First magnetic resonance imaging (MRI) findings revealed that most of the lesions were in the periventricular (83%) and re-imaging in 25 cases showed completely or partially resolution of previous lesions with no new lesion in 18 (72%) and 7 (28%) patients, respectively.
Conclusion: We found some controversies to previous studies in epidemiological and imaging studies which could be of a significant role in detecting and accurate diagnosis of acute disseminated encephalomyelitis which can significantly impact on physicians’ view of the disease. |
| first_indexed | 2024-03-12T09:18:06Z |
| format | Article |
| id | doaj.art-83f3f2bd67a84c8b84104f8ed099ff3d |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:18:06Z |
| publishDate | 2015-09-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-83f3f2bd67a84c8b84104f8ed099ff3d2023-09-02T14:43:27ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2015-09-0133343114711561950The Epidemiologic and Demographic Characteristics and Clinical Findings in Patients with Acute Disseminated Encephalomyelitis (ADEM) Referred to Alzahra Hospital, Isfahan, Iran, During 10 Years (2003-2013)Masoud Etemadifar0Farzaneh Kadkhodaei1Mohammadreza Najafi2Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranProfessor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Acute disseminated encephalomyelitis (ADEM) is an uncommon monophasic disease often with good prognosis. It is a differential diagnosis of multiple sclerosis (MS). Accurate distinction between acute disseminated encephalomyelitis and multiple sclerosis is important for prognosis and treatment; as many patients with multiple sclerosis may benefit from early disease-modifying therapy to suppress ongoing and future relapses. Methods: In a retrograde study, all the patients presented to Alzahra hospital (Isfahan, Iran) with definite diagnosis of acute disseminated encephalomyelitis during a 10-year period were included. Demographic data, clinical signs and symptoms, and laboratory and imaging findings were collected and analyzed using t and chi-square tests via SPSS software. Findings: Forty-two patients with mean age of 20.05 ± 10.04 years and a female-predominance of 64.3% participated in the study. Thirty-three patients (78.6%) had a recent history of infectious disease. A seasonal pattern of distribution in spring (31%) and autumn (31%) was seen. The cerebrospinal fluid (CSF) analysis findings showed pleocytosis and increased protein in 26 (61.9%) and 25 (59.6%) cases, respectively. First magnetic resonance imaging (MRI) findings revealed that most of the lesions were in the periventricular (83%) and re-imaging in 25 cases showed completely or partially resolution of previous lesions with no new lesion in 18 (72%) and 7 (28%) patients, respectively. Conclusion: We found some controversies to previous studies in epidemiological and imaging studies which could be of a significant role in detecting and accurate diagnosis of acute disseminated encephalomyelitis which can significantly impact on physicians’ view of the disease.http://jims.mui.ac.ir/index.php/jims/article/view/5199Acute disseminated encephalomyelitis (ADEM)Multiple sclerosis (MS)Differential diagnosis |
| spellingShingle | Masoud Etemadifar Farzaneh Kadkhodaei Mohammadreza Najafi The Epidemiologic and Demographic Characteristics and Clinical Findings in Patients with Acute Disseminated Encephalomyelitis (ADEM) Referred to Alzahra Hospital, Isfahan, Iran, During 10 Years (2003-2013) مجله دانشکده پزشکی اصفهان Acute disseminated encephalomyelitis (ADEM) Multiple sclerosis (MS) Differential diagnosis |
| title | The Epidemiologic and Demographic Characteristics and Clinical Findings in Patients with Acute Disseminated Encephalomyelitis (ADEM) Referred to Alzahra Hospital, Isfahan, Iran, During 10 Years (2003-2013) |
| title_full | The Epidemiologic and Demographic Characteristics and Clinical Findings in Patients with Acute Disseminated Encephalomyelitis (ADEM) Referred to Alzahra Hospital, Isfahan, Iran, During 10 Years (2003-2013) |
| title_fullStr | The Epidemiologic and Demographic Characteristics and Clinical Findings in Patients with Acute Disseminated Encephalomyelitis (ADEM) Referred to Alzahra Hospital, Isfahan, Iran, During 10 Years (2003-2013) |
| title_full_unstemmed | The Epidemiologic and Demographic Characteristics and Clinical Findings in Patients with Acute Disseminated Encephalomyelitis (ADEM) Referred to Alzahra Hospital, Isfahan, Iran, During 10 Years (2003-2013) |
| title_short | The Epidemiologic and Demographic Characteristics and Clinical Findings in Patients with Acute Disseminated Encephalomyelitis (ADEM) Referred to Alzahra Hospital, Isfahan, Iran, During 10 Years (2003-2013) |
| title_sort | epidemiologic and demographic characteristics and clinical findings in patients with acute disseminated encephalomyelitis adem referred to alzahra hospital isfahan iran during 10 years 2003 2013 |
| topic | Acute disseminated encephalomyelitis (ADEM) Multiple sclerosis (MS) Differential diagnosis |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/5199 |
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