Sympathetic improvement of cancer vaccine efficacy
The link between stress, other psychological factors and response to cancer, or even the cancer incidence and metastasis, is well established. The inhibition of β-Adrenergic receptors (β-AR) using β-blockers was demonstrated to have an inhibitory effect on cancer recurrence. Direct effects on the st...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-08-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2019.1703456 |
| _version_ | 1797677351662780416 |
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| author | Else Marit Inderberg Sébastien Wälchli |
| author_facet | Else Marit Inderberg Sébastien Wälchli |
| author_sort | Else Marit Inderberg |
| collection | DOAJ |
| description | The link between stress, other psychological factors and response to cancer, or even the cancer incidence and metastasis, is well established. The inhibition of β-Adrenergic receptors (β-AR) using β-blockers was demonstrated to have an inhibitory effect on cancer recurrence. Direct effects on the stress-induced suppression of anti-tumor immune responses were also shown. In a recent issue of Cancer Immunology Research, Daher and colleagues studied the molecular mechanism behind this protective effect in the context of cancer vaccination. They provided evidence that the β-AR signaling affected the priming of naïve CD8 + T cells in their myeloma model, rather than effector CD8 + T cells which downregulated the expression of β-AR after activation and became insensitive to such signaling. Blocking the β-adrenergic signaling during vaccination led to increased expansion and effector functions of antigen-specific CD8 + T cells and reduced tumor growth. This has implications for the clinical use of β-blockers as adjuvants to enhance cancer vaccination and other types of immunotherapy. |
| first_indexed | 2024-03-11T22:43:04Z |
| format | Article |
| id | doaj.art-83f4f9efa795409d85a6457baf6a0ffe |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:43:04Z |
| publishDate | 2020-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-83f4f9efa795409d85a6457baf6a0ffe2023-09-22T08:45:35ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2020-08-011681888189010.1080/21645515.2019.17034561703456Sympathetic improvement of cancer vaccine efficacyElse Marit Inderberg0Sébastien Wälchli1Oslo University Hospital-The Norwegian Radium HospitalOslo University Hospital-The Norwegian Radium HospitalThe link between stress, other psychological factors and response to cancer, or even the cancer incidence and metastasis, is well established. The inhibition of β-Adrenergic receptors (β-AR) using β-blockers was demonstrated to have an inhibitory effect on cancer recurrence. Direct effects on the stress-induced suppression of anti-tumor immune responses were also shown. In a recent issue of Cancer Immunology Research, Daher and colleagues studied the molecular mechanism behind this protective effect in the context of cancer vaccination. They provided evidence that the β-AR signaling affected the priming of naïve CD8 + T cells in their myeloma model, rather than effector CD8 + T cells which downregulated the expression of β-AR after activation and became insensitive to such signaling. Blocking the β-adrenergic signaling during vaccination led to increased expansion and effector functions of antigen-specific CD8 + T cells and reduced tumor growth. This has implications for the clinical use of β-blockers as adjuvants to enhance cancer vaccination and other types of immunotherapy.http://dx.doi.org/10.1080/21645515.2019.1703456cancer vaccinedcsympathetic nervous systemβ-adrenergic receptors |
| spellingShingle | Else Marit Inderberg Sébastien Wälchli Sympathetic improvement of cancer vaccine efficacy Human Vaccines & Immunotherapeutics cancer vaccine dc sympathetic nervous system β-adrenergic receptors |
| title | Sympathetic improvement of cancer vaccine efficacy |
| title_full | Sympathetic improvement of cancer vaccine efficacy |
| title_fullStr | Sympathetic improvement of cancer vaccine efficacy |
| title_full_unstemmed | Sympathetic improvement of cancer vaccine efficacy |
| title_short | Sympathetic improvement of cancer vaccine efficacy |
| title_sort | sympathetic improvement of cancer vaccine efficacy |
| topic | cancer vaccine dc sympathetic nervous system β-adrenergic receptors |
| url | http://dx.doi.org/10.1080/21645515.2019.1703456 |
| work_keys_str_mv | AT elsemaritinderberg sympatheticimprovementofcancervaccineefficacy AT sebastienwalchli sympatheticimprovementofcancervaccineefficacy |