<em>In vivo</em> anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol
Background: Indonesia is the world’s primary producer of clove. In order to find new utilization for clove and new biologically active compounds, eugenol, the main constituent of clove, has been converted to its derivatives. Objective: This study aims to examine in vivo anticancer activity of ben...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-03-01
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| Series: | Journal of Public Health in Africa |
| Subjects: | |
| Online Access: | https://publichealthinafrica.org/jphia/article/view/2511 |
| _version_ | 1797868083043368960 |
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| author | Marcellino Rudyanto Juni Ekowati Tri Widiandani Achmad Syahrani |
| author_facet | Marcellino Rudyanto Juni Ekowati Tri Widiandani Achmad Syahrani |
| author_sort | Marcellino Rudyanto |
| collection | DOAJ |
| description |
Background: Indonesia is the world’s primary producer of clove. In order to find new utilization for clove and new biologically active compounds, eugenol, the main constituent of clove, has been converted to its derivatives.
Objective: This study aims to examine in vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol.
Methods: Fibrosarcoma was induced by injection of benzo(a)pyrene solution. The test compounds were given per oral at 20, 40, and 80 mg/Kg body weight, once a day for 30 days.
Results: As a result, all the tested compounds showed activity in reducing the cancer incidence rate. All the tested compounds were also found to reduce tumor weight. Benzoxazine derivatives gave slightly better activity compared to aminomethyl derivatives. The strongest activity was exhibited by 6-allyl-3-(furan-2- ylmethyl)-8-methoxy-3,4-dihydro-2H-benzo(e)(1,3)oxazine.
Conclusions: All four benzoxazine and aminomethyl compounds derived from eugenol that were tested exhibited anticancer activity in mice fibrosarcoma.
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| first_indexed | 2024-04-09T23:50:22Z |
| format | Article |
| id | doaj.art-83f792bf874c4104860c90d0e20ef219 |
| institution | Directory Open Access Journal |
| issn | 2038-9922 2038-9930 |
| language | English |
| last_indexed | 2024-04-09T23:50:22Z |
| publishDate | 2023-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Public Health in Africa |
| spelling | doaj.art-83f792bf874c4104860c90d0e20ef2192023-03-17T10:11:05ZengPAGEPress PublicationsJournal of Public Health in Africa2038-99222038-99302023-03-0114s110.4081/jphia.2023.2511<em>In vivo</em> anticancer activity of benzoxazine and aminomethyl compounds derived from eugenolMarcellino Rudyanto0Juni Ekowati1Tri Widiandani2Achmad Syahrani3Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya; Institute of Tropical Disease, Universitas Airlangga, SurabayaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, SurabayaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, SurabayaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya Background: Indonesia is the world’s primary producer of clove. In order to find new utilization for clove and new biologically active compounds, eugenol, the main constituent of clove, has been converted to its derivatives. Objective: This study aims to examine in vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol. Methods: Fibrosarcoma was induced by injection of benzo(a)pyrene solution. The test compounds were given per oral at 20, 40, and 80 mg/Kg body weight, once a day for 30 days. Results: As a result, all the tested compounds showed activity in reducing the cancer incidence rate. All the tested compounds were also found to reduce tumor weight. Benzoxazine derivatives gave slightly better activity compared to aminomethyl derivatives. The strongest activity was exhibited by 6-allyl-3-(furan-2- ylmethyl)-8-methoxy-3,4-dihydro-2H-benzo(e)(1,3)oxazine. Conclusions: All four benzoxazine and aminomethyl compounds derived from eugenol that were tested exhibited anticancer activity in mice fibrosarcoma. https://publichealthinafrica.org/jphia/article/view/2511Eugenolbenzoxazinesaminomethylanticancer |
| spellingShingle | Marcellino Rudyanto Juni Ekowati Tri Widiandani Achmad Syahrani <em>In vivo</em> anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol Journal of Public Health in Africa Eugenol benzoxazines aminomethyl anticancer |
| title | <em>In vivo</em> anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol |
| title_full | <em>In vivo</em> anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol |
| title_fullStr | <em>In vivo</em> anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol |
| title_full_unstemmed | <em>In vivo</em> anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol |
| title_short | <em>In vivo</em> anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol |
| title_sort | em in vivo em anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol |
| topic | Eugenol benzoxazines aminomethyl anticancer |
| url | https://publichealthinafrica.org/jphia/article/view/2511 |
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