Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages[S]

Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages[S]

Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-CoAs to FFAs. ACOT7 is induced by lipopolysaccharide (LPS); thus, we investigated downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells. Enzymatic thioesterase activity...

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Bibliographic Details
Main Authors: Valerie Z. Wall, Shelley Barnhart, Farah Kramer, Jenny E. Kanter, Anuradha Vivekanandan-Giri, Subramaniam Pennathur, Chiara Bolego, Jessica M. Ellis, Miguel A. Gijón, Michael J. Wolfgang, Karin E. Bornfeldt
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
cytokines
diabetes
fatty acid
inflammation
lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310099

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