Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS)
Abstract Background Recurrent aphthous stomatitis (RAS) is an ulcerative disease of the oral mucosa without a clearly defined etiology. The aim of the study was to evaluate the serum zinc levels in patients with RAS in comparison to healthy controls and to validate the association between zinc level...
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Oral Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12903-017-0450-x |
| _version_ | 1818955587761733632 |
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| author | Zuzanna Ślebioda Ewa Krawiecka Elżbieta Szponar Barbara Dorocka-Bobkowska |
| author_facet | Zuzanna Ślebioda Ewa Krawiecka Elżbieta Szponar Barbara Dorocka-Bobkowska |
| author_sort | Zuzanna Ślebioda |
| collection | DOAJ |
| description | Abstract Background Recurrent aphthous stomatitis (RAS) is an ulcerative disease of the oral mucosa without a clearly defined etiology. The aim of the study was to evaluate the serum zinc levels in patients with RAS in comparison to healthy controls and to validate the association between zinc levels and the course of RAS. Methods Seventy-five patients with RAS and 72 controls underwent full dental examination. Serum zinc levels were determined by flame atomic absorption spectroscopy (F AAS). The results were statistically analyzed with Kruskal-Wallis, Mann-Whitney, chi-square tests and the test of difference between the two rates of structure with p < 0.05 as a significance level (Statistica 10, StatSoft®). Results No statistically significant differences were detected in serum zinc levels between RAS patients and healthy controls. The mean serum zinc concentration was found to be 84.2 μg/dL in RAS group and 83.9 μd/dL in controls, within the accepted norms. Zinc deficiency was observed in 10.7% patients from the RAS group and in 6.9% controls. No significant differences in serum zinc levels were found between patients when the course of the disease was considered. Conclusions Serum zinc concentrations did not differ significantly in RAS patients and in healthy controls and it did not influence the course of the disease. Therefore, zinc does not appear to be an important modifying factor in the development of RAS. |
| first_indexed | 2024-12-20T10:40:26Z |
| format | Article |
| id | doaj.art-83f8bb40d0524367a480828614b4f393 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-12-20T10:40:26Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-83f8bb40d0524367a480828614b4f3932022-12-21T19:43:33ZengBMCBMC Oral Health1472-68312017-12-011711710.1186/s12903-017-0450-xEvaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS)Zuzanna Ślebioda0Ewa Krawiecka1Elżbieta Szponar2Barbara Dorocka-Bobkowska3Department of Gerodontology and Oral Pathology, University of Medical SciencesDepartment of Gerodontology and Oral Pathology, University of Medical SciencesDepartment of Gerodontology and Oral Pathology, University of Medical SciencesDepartment of Gerodontology and Oral Pathology, University of Medical SciencesAbstract Background Recurrent aphthous stomatitis (RAS) is an ulcerative disease of the oral mucosa without a clearly defined etiology. The aim of the study was to evaluate the serum zinc levels in patients with RAS in comparison to healthy controls and to validate the association between zinc levels and the course of RAS. Methods Seventy-five patients with RAS and 72 controls underwent full dental examination. Serum zinc levels were determined by flame atomic absorption spectroscopy (F AAS). The results were statistically analyzed with Kruskal-Wallis, Mann-Whitney, chi-square tests and the test of difference between the two rates of structure with p < 0.05 as a significance level (Statistica 10, StatSoft®). Results No statistically significant differences were detected in serum zinc levels between RAS patients and healthy controls. The mean serum zinc concentration was found to be 84.2 μg/dL in RAS group and 83.9 μd/dL in controls, within the accepted norms. Zinc deficiency was observed in 10.7% patients from the RAS group and in 6.9% controls. No significant differences in serum zinc levels were found between patients when the course of the disease was considered. Conclusions Serum zinc concentrations did not differ significantly in RAS patients and in healthy controls and it did not influence the course of the disease. Therefore, zinc does not appear to be an important modifying factor in the development of RAS.http://link.springer.com/article/10.1186/s12903-017-0450-xRecurrent aphthous stomatitisZincOral mucosaOral diseases |
| spellingShingle | Zuzanna Ślebioda Ewa Krawiecka Elżbieta Szponar Barbara Dorocka-Bobkowska Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS) BMC Oral Health Recurrent aphthous stomatitis Zinc Oral mucosa Oral diseases |
| title | Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS) |
| title_full | Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS) |
| title_fullStr | Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS) |
| title_full_unstemmed | Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS) |
| title_short | Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS) |
| title_sort | evaluation of serum zinc levels in patients with recurrent aphthous stomatitis ras |
| topic | Recurrent aphthous stomatitis Zinc Oral mucosa Oral diseases |
| url | http://link.springer.com/article/10.1186/s12903-017-0450-x |
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