Multi-mtDNA Variants May Be a Factor Contributing to Mitochondrial Function Variety in the Skin-Derived Fibroblasts of Leber's Hereditary Optic Neuropathy Patients

Multi-mtDNA Variants May Be a Factor Contributing to Mitochondrial Function Variety in the Skin-Derived Fibroblasts of Leber's Hereditary Optic Neuropathy Patients

Heterogeneity is a major feature of Leber's hereditary optic neuropathy (LHON) and has a significant impact on the manifestation and diagnosis of the disease. This study explored whether multiple variations in mitochondrial genes were associated with the heterogeneity, mainly phenotypic heterog...

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Bibliographic Details
Main Authors: Shun Yao, Qingru Zhou, Mingzhu Yang, Ya Li, Xiuxiu Jin, Qingge Guo, Lin Yang, Fangyuan Qin, Bo Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Leber's hereditary optic neuropathy (LHON)
mitochondria dysfunction
heterogeneity
mtDNA variants
cell viability
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.920221/full

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