Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives
Background: First-degree relatives (FDRs) of hypertensive (HT) are predisposed to hypertension (HTN) which accelerates cardiovascular aging. Same can be studied noninvasively by pulse wave analysis (PWA), encompassing central hemodynamics such as central blood pressure (cBP), cardiac output, and str...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=72;epage=72;aulast=Solanki |
| _version_ | 1818941457806917632 |
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| author | Jayesh Dalpatbhai Solanki Hemant B Mehta Chinmay J Shah |
| author_facet | Jayesh Dalpatbhai Solanki Hemant B Mehta Chinmay J Shah |
| author_sort | Jayesh Dalpatbhai Solanki |
| collection | DOAJ |
| description | Background: First-degree relatives (FDRs) of hypertensive (HT) are predisposed to hypertension (HTN) which accelerates cardiovascular aging. Same can be studied noninvasively by pulse wave analysis (PWA), encompassing central hemodynamics such as central blood pressure (cBP), cardiac output, and stroke work (SW) and vascular stiffness parameters such as pulse wave velocity (PWV) and augmentation index at HR 75 (AIx@75). We studied PWA-derived cardiovascular parameters in FDRs of HT compared to controls. Materials and Methods: We conducted a case–control study in 119 FDRs of HT and 119 matched controls. Oscillometric PWA was performed by Mobil-o-Graph (IEM, Germany) and cardiovascular parameters were compared. P < 0.05 was considered statistically significant. Results: Groups were comparable with gender, age, height, weight, body mass index, and physical activity. FDRs of HT had significantly higher brachial and cBPs, SW (101.41 ± 25.44 vs. 88.31 ± 20.25, P = 0.001), rate pressure product-119.40 ± 25.34 vs. 108.34 ± 18.17, P < 0.0001), PWV (5.22 ± 0.46, P < 0.0001), and AIx@75 (31.48 ± 9.01 vs. 27.95 ± 9.4, P = 0.002) than control. Dependent study variables correlated with brachial blood pressure more in magnitude and significance level than age or anthropometric variables. PWA results of FDR with maternal inheritance did not differ significantly from those with paternal inheritance. Conclusion: PWA reveals early cardiovascular aging in young FDRs of HTs. It clues to future cardiovascular disease including HTN itself, need for primary prevention, and further study for consolidation of these results. |
| first_indexed | 2024-12-20T06:55:51Z |
| format | Article |
| id | doaj.art-83f95c887223438185880225fa6b660b |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-20T06:55:51Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-83f95c887223438185880225fa6b660b2022-12-21T19:49:21ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362018-01-01231727210.4103/jrms.JRMS_581_16Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensivesJayesh Dalpatbhai SolankiHemant B MehtaChinmay J ShahBackground: First-degree relatives (FDRs) of hypertensive (HT) are predisposed to hypertension (HTN) which accelerates cardiovascular aging. Same can be studied noninvasively by pulse wave analysis (PWA), encompassing central hemodynamics such as central blood pressure (cBP), cardiac output, and stroke work (SW) and vascular stiffness parameters such as pulse wave velocity (PWV) and augmentation index at HR 75 (AIx@75). We studied PWA-derived cardiovascular parameters in FDRs of HT compared to controls. Materials and Methods: We conducted a case–control study in 119 FDRs of HT and 119 matched controls. Oscillometric PWA was performed by Mobil-o-Graph (IEM, Germany) and cardiovascular parameters were compared. P < 0.05 was considered statistically significant. Results: Groups were comparable with gender, age, height, weight, body mass index, and physical activity. FDRs of HT had significantly higher brachial and cBPs, SW (101.41 ± 25.44 vs. 88.31 ± 20.25, P = 0.001), rate pressure product-119.40 ± 25.34 vs. 108.34 ± 18.17, P < 0.0001), PWV (5.22 ± 0.46, P < 0.0001), and AIx@75 (31.48 ± 9.01 vs. 27.95 ± 9.4, P = 0.002) than control. Dependent study variables correlated with brachial blood pressure more in magnitude and significance level than age or anthropometric variables. PWA results of FDR with maternal inheritance did not differ significantly from those with paternal inheritance. Conclusion: PWA reveals early cardiovascular aging in young FDRs of HTs. It clues to future cardiovascular disease including HTN itself, need for primary prevention, and further study for consolidation of these results.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=72;epage=72;aulast=SolankiCardiovascularfirst degree relativehypertensiveoscillometricpulse wave analysis |
| spellingShingle | Jayesh Dalpatbhai Solanki Hemant B Mehta Chinmay J Shah Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives Journal of Research in Medical Sciences Cardiovascular first degree relative hypertensive oscillometric pulse wave analysis |
| title | Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives |
| title_full | Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives |
| title_fullStr | Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives |
| title_full_unstemmed | Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives |
| title_short | Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives |
| title_sort | pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives |
| topic | Cardiovascular first degree relative hypertensive oscillometric pulse wave analysis |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=72;epage=72;aulast=Solanki |
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