Trained hypertensive rats exhibit decreased transcellular vesicle trafficking, increased tight junctions’ density, restored blood-brain barrier permeability and normalized autonomic control of the circulation

Trained hypertensive rats exhibit decreased transcellular vesicle trafficking, increased tight junctions’ density, restored blood-brain barrier permeability and normalized autonomic control of the circulation

Introduction: Chronic hypertension is accompanied by either blood-brain barrier (BBB) leakage and autonomic dysfunction. There is no consensus on the mechanism determining increased BBB permeability within autonomic areas. While some reports suggested tight junction’s breakdown, others indicated the...

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Bibliographic Details
Main Authors: Vanessa B. Candido, Sany M. Perego, Alexandre Ceroni, Martin Metzger, Alison Colquhoun, Lisete C. Michelini
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Physiology
Subjects:
aerobic exercise training
autonomic control
blood-brain barrier
transcytosis
paracellular transport
spontaneously hypertensive rats (SHR)
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1069485/full

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