Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patients
Magnetic resonance-guided focused ultrasound (MRgFUS) lesioning of the ventralis intermedius nucleus (VIM) has shown promise in treating drug-refractory essential tremor (ET). It remains unknown whether focal VIM lesions by MRgFUS have broader restorative effects on information flow within the whole...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Brain Stimulation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X23017734 |
| _version_ | 1797798081969782784 |
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| author | Julia M. Lueckel Neeraj Upadhyay Veronika Purrer Angelika Maurer Valeri Borger Alexander Radbruch Ulrike Attenberger Ullrich Wuellner Rajanikant Panda Henning Boecker |
| author_facet | Julia M. Lueckel Neeraj Upadhyay Veronika Purrer Angelika Maurer Valeri Borger Alexander Radbruch Ulrike Attenberger Ullrich Wuellner Rajanikant Panda Henning Boecker |
| author_sort | Julia M. Lueckel |
| collection | DOAJ |
| description | Magnetic resonance-guided focused ultrasound (MRgFUS) lesioning of the ventralis intermedius nucleus (VIM) has shown promise in treating drug-refractory essential tremor (ET). It remains unknown whether focal VIM lesions by MRgFUS have broader restorative effects on information flow within the whole-brain network of ET patients. We applied an information-theoretical approach based on intrinsic ignition and the concept of transfer entropy (TE) to assess the spatiotemporal dynamics after VIM-MRgFUS. Eighteen ET patients (mean age 71.44 years) underwent repeated 3T resting-state functional magnetic resonance imaging combined with Clinical Rating Scale for Tremor (CRST) assessments one day before (T0) and one month (T1) and six months (T2) post-MRgFUS, respectively. We observed increased whole brain ignition-driven mean integration (IDMI) at T1 (p < 0.05), along with trend increases at T2. Further, constraining to motor network nodes, we identified significant increases in information-broadcasting (bilateral supplementary motor area (SMA) and left cerebellar lobule III) and information-receiving (right precentral gyrus) at T1. Remarkably, increased information-broadcasting in bilateral SMA was correlated with relative improvement of the CRST in the treated hand. In addition, causal TE-based effective connectivity (EC) at T1 showed an increase from right SMA to left cerebellar lobule crus II and from left cerebellar lobule III to right thalamus. In conclusion, results suggest a change in information transmission capacity in ET after MRgFUS and a shift towards a more integrated functional state with increased levels of global and directional information flow. |
| first_indexed | 2024-03-13T03:59:06Z |
| format | Article |
| id | doaj.art-83fef3480b4b4f5ba1fae8f91f6593a1 |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-03-13T03:59:06Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-83fef3480b4b4f5ba1fae8f91f6593a12023-06-22T05:02:45ZengElsevierBrain Stimulation1935-861X2023-05-01163879888Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patientsJulia M. Lueckel0Neeraj Upadhyay1Veronika Purrer2Angelika Maurer3Valeri Borger4Alexander Radbruch5Ulrike Attenberger6Ullrich Wuellner7Rajanikant Panda8Henning Boecker9Clinical Functional Imaging Group, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, GermanyClinical Functional Imaging Group, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, GermanyGerman Center for Neurodegenerative Diseases, Bonn, Germany; Department of Neurology, University Hospital Bonn, Bonn, GermanyClinical Functional Imaging Group, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, Bonn, GermanyDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases, Bonn, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, GermanyGerman Center for Neurodegenerative Diseases, Bonn, Germany; Department of Neurology, University Hospital Bonn, Bonn, GermanyComa Science Group, GIGA-Consciousness, University of Liège, Liège, BelgiumClinical Functional Imaging Group, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases, Bonn, Germany; Corresponding author. Clinical Functional Imaging Group, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany.Magnetic resonance-guided focused ultrasound (MRgFUS) lesioning of the ventralis intermedius nucleus (VIM) has shown promise in treating drug-refractory essential tremor (ET). It remains unknown whether focal VIM lesions by MRgFUS have broader restorative effects on information flow within the whole-brain network of ET patients. We applied an information-theoretical approach based on intrinsic ignition and the concept of transfer entropy (TE) to assess the spatiotemporal dynamics after VIM-MRgFUS. Eighteen ET patients (mean age 71.44 years) underwent repeated 3T resting-state functional magnetic resonance imaging combined with Clinical Rating Scale for Tremor (CRST) assessments one day before (T0) and one month (T1) and six months (T2) post-MRgFUS, respectively. We observed increased whole brain ignition-driven mean integration (IDMI) at T1 (p < 0.05), along with trend increases at T2. Further, constraining to motor network nodes, we identified significant increases in information-broadcasting (bilateral supplementary motor area (SMA) and left cerebellar lobule III) and information-receiving (right precentral gyrus) at T1. Remarkably, increased information-broadcasting in bilateral SMA was correlated with relative improvement of the CRST in the treated hand. In addition, causal TE-based effective connectivity (EC) at T1 showed an increase from right SMA to left cerebellar lobule crus II and from left cerebellar lobule III to right thalamus. In conclusion, results suggest a change in information transmission capacity in ET after MRgFUS and a shift towards a more integrated functional state with increased levels of global and directional information flow.http://www.sciencedirect.com/science/article/pii/S1935861X23017734Essential tremorMR-Guided focused ultrasoundVentral intermediate nucleusInformation theoryIntrinsic ignition frameworkTransfer entropy |
| spellingShingle | Julia M. Lueckel Neeraj Upadhyay Veronika Purrer Angelika Maurer Valeri Borger Alexander Radbruch Ulrike Attenberger Ullrich Wuellner Rajanikant Panda Henning Boecker Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patients Brain Stimulation Essential tremor MR-Guided focused ultrasound Ventral intermediate nucleus Information theory Intrinsic ignition framework Transfer entropy |
| title | Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patients |
| title_full | Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patients |
| title_fullStr | Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patients |
| title_full_unstemmed | Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patients |
| title_short | Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patients |
| title_sort | whole brain network transitions within the framework of ignition and transfer entropy following vim mrgfus in essential tremor patients |
| topic | Essential tremor MR-Guided focused ultrasound Ventral intermediate nucleus Information theory Intrinsic ignition framework Transfer entropy |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X23017734 |
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