The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply genomic, genetic, and biochemical approaches...

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Bibliographic Details
Main Authors: Sofia Aligianni, Daniel H Lackner, Steffi Klier, Gabriella Rustici, Brian T Wilhelm, Samuel Marguerat, Sandra Codlin, Alvis Brazma, Robertus A M de Bruin, Jürg Bähler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2726434?pdf=render

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http://europepmc.org/articles/PMC2726434?pdf=render

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