Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis
Positron emission tomography using ligands targeting translocator protein 18 kDa (TSPO PET) is an innovative method to visualize and quantify glial inflammatory responses in the central nervous system in vivo. Compared to some other neuropsychiatric disorders, findings of TSPO PET in schizophrenia a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00362/full |
| _version_ | 1819139868575399936 |
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| author | Livia De Picker Livia De Picker Manuel Morrens Manuel Morrens |
| author_facet | Livia De Picker Livia De Picker Manuel Morrens Manuel Morrens |
| author_sort | Livia De Picker |
| collection | DOAJ |
| description | Positron emission tomography using ligands targeting translocator protein 18 kDa (TSPO PET) is an innovative method to visualize and quantify glial inflammatory responses in the central nervous system in vivo. Compared to some other neuropsychiatric disorders, findings of TSPO PET in schizophrenia and related psychotic disorders have been considerably more heterogeneous. Two conflicting meta-analyses have been published on the topic within the last year: one asserting evidence for decreased TSPO uptake, while the other observed increased TSPO uptake in a selection of studies. In this paper, we review and discuss five hypotheses which may explain the observed variability of TSPO PET findings in psychotic illness, namely that (1) an inflammatory phenotype is only present in a subgroup of psychosis patients; (2) heterogeneity is caused by interference of antipsychotic medication; (3) interference of other clinical confounders in the study populations (such as age, sex, BMI, smoking, and substance use); or (4) methodological variability between studies (such as choice of tracer and kinetic model, genotyping, study power, and diurnal effects); and (5) the glial responses underlying changes in TSPO expression are themselves heterogeneous and dynamic. Finally, we propose four key recommendations for future research proposals to mitigate these different causes of heterogeneity. |
| first_indexed | 2024-12-22T11:29:30Z |
| format | Article |
| id | doaj.art-8400819989dc495cb23a545cb1476ba7 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T11:29:30Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-8400819989dc495cb23a545cb1476ba72022-12-21T18:27:39ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-05-011110.3389/fpsyt.2020.00362510979Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in PsychosisLivia De Picker0Livia De Picker1Manuel Morrens2Manuel Morrens3Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, BelgiumSINAPS, University Psychiatric Hospital Campus Duffel, Duffel, BelgiumCollaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, BelgiumSINAPS, University Psychiatric Hospital Campus Duffel, Duffel, BelgiumPositron emission tomography using ligands targeting translocator protein 18 kDa (TSPO PET) is an innovative method to visualize and quantify glial inflammatory responses in the central nervous system in vivo. Compared to some other neuropsychiatric disorders, findings of TSPO PET in schizophrenia and related psychotic disorders have been considerably more heterogeneous. Two conflicting meta-analyses have been published on the topic within the last year: one asserting evidence for decreased TSPO uptake, while the other observed increased TSPO uptake in a selection of studies. In this paper, we review and discuss five hypotheses which may explain the observed variability of TSPO PET findings in psychotic illness, namely that (1) an inflammatory phenotype is only present in a subgroup of psychosis patients; (2) heterogeneity is caused by interference of antipsychotic medication; (3) interference of other clinical confounders in the study populations (such as age, sex, BMI, smoking, and substance use); or (4) methodological variability between studies (such as choice of tracer and kinetic model, genotyping, study power, and diurnal effects); and (5) the glial responses underlying changes in TSPO expression are themselves heterogeneous and dynamic. Finally, we propose four key recommendations for future research proposals to mitigate these different causes of heterogeneity.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00362/fulltranslocator proteinschizophreniapsychosismicrogliapositron emission tomographyneuroinflammation |
| spellingShingle | Livia De Picker Livia De Picker Manuel Morrens Manuel Morrens Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis Frontiers in Psychiatry translocator protein schizophrenia psychosis microglia positron emission tomography neuroinflammation |
| title | Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis |
| title_full | Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis |
| title_fullStr | Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis |
| title_full_unstemmed | Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis |
| title_short | Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis |
| title_sort | perspective solving the heterogeneity conundrum of tspo pet imaging in psychosis |
| topic | translocator protein schizophrenia psychosis microglia positron emission tomography neuroinflammation |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00362/full |
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