Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen
BackgroundGenetic factors increase the individual risk of colorectal cancer (CRC); however, the extent to which a healthy lifestyle can offset increased genetic risk is unknown. This study investigated whether a healthy lifestyle is associated with lower CRC risk, regardless of genetic risk.MethodsW...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.894086/full |
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| author | E. Wu E. Wu Jun-Tao Ni Xin Chen Zhao-Hui Zhu Hong-Quan Xu Hong-Quan Xu Lin Tao Lin Tao Tian Xie Tian Xie |
| author_facet | E. Wu E. Wu Jun-Tao Ni Xin Chen Zhao-Hui Zhu Hong-Quan Xu Hong-Quan Xu Lin Tao Lin Tao Tian Xie Tian Xie |
| author_sort | E. Wu |
| collection | DOAJ |
| description | BackgroundGenetic factors increase the individual risk of colorectal cancer (CRC); however, the extent to which a healthy lifestyle can offset increased genetic risk is unknown. This study investigated whether a healthy lifestyle is associated with lower CRC risk, regardless of genetic risk.MethodsWe recruited 390,365 participants without cancer at baseline (2006–2010) from the UK Biobank. The primary outcome was CRC incidence. A healthy lifestyle score constructed using 16 factors of six dimensions (smoking, drinking, body mass index, diet, exercise, and sleep) was categorized into three risk categories: favorable, intermediate, and unfavorable. To calculate the polygenic risk scores (PRSs) of UK Biobank participants, we extracted 454,678 single nucleotide polymorphisms (SNPs) from the UK Biobank and FinnGen Biobank after quality control. Cox proportional hazards regression was performed to evaluate the associations and was expressed as hazard ratios (HRs) with 95% confidence intervals (CIs).ResultsDuring a median follow-up of 10.90 years, 4,090 new CRC cases were reported in the UK Biobank. The “best-fit” PRSs were constructed using 59 SNPs based on the UK Biobank cohort and FinnGen genome-wide association study summary data (R2 = 0.23%) and were divided into low (lowest quintile), intermediate (including second–fourth quintile), and high (highest quintile) genetic risk categories. The multivariate-adjusted Cox model revealed that participants with favorable lifestyles had HRs of 0.66 (95% CI = 0.60–0.72) for developing CRC vs. those with unfavorable lifestyles; low genetic risk was associated with a decreased risk of CRC (HR = 0.67, 95% CI =0.61–0.74) compared with those with high genetic risk. The HRs for low genetic risk participants with favorable lifestyles were 0.44 (95% CI =0.36–0.55) vs. participants with high genetic risk and unfavorable lifestyles. Among the participants with low, intermediate, or high genetic risk, the HRs of favorable vs. unfavorable lifestyles were 0.74, 0.64, and 0.72 (all p< 0.05).ConclusionsLow genetic risk and a favorable lifestyle were significantly associated with a decreased risk of CRC. A favorable lifestyle was associated with a lower CRC risk, regardless of genetic risk. |
| first_indexed | 2024-04-13T23:18:33Z |
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| last_indexed | 2024-04-13T23:18:33Z |
| publishDate | 2022-10-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-84049416edc54728aeea2768afaaac1b2022-12-22T02:25:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.894086894086Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGenE. Wu0E. Wu1Jun-Tao Ni2Xin Chen3Zhao-Hui Zhu4Hong-Quan Xu5Hong-Quan Xu6Lin Tao7Lin Tao8Tian Xie9Tian Xie10School of Pharmacy, Hangzhou Normal University, Hangzhou, ChinaSchool of Public Health, Hangzhou Normal University, Zhejiang, ChinaScientific Research Department, Women’s Hospital School of Medicine Zhejiang University, Hangzhou, ChinaSchool of Public Health, Hangzhou Normal University, Zhejiang, ChinaSchool of Public Health, Hangzhou Normal University, Zhejiang, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, ChinaKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, ChinaKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, ChinaKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaBackgroundGenetic factors increase the individual risk of colorectal cancer (CRC); however, the extent to which a healthy lifestyle can offset increased genetic risk is unknown. This study investigated whether a healthy lifestyle is associated with lower CRC risk, regardless of genetic risk.MethodsWe recruited 390,365 participants without cancer at baseline (2006–2010) from the UK Biobank. The primary outcome was CRC incidence. A healthy lifestyle score constructed using 16 factors of six dimensions (smoking, drinking, body mass index, diet, exercise, and sleep) was categorized into three risk categories: favorable, intermediate, and unfavorable. To calculate the polygenic risk scores (PRSs) of UK Biobank participants, we extracted 454,678 single nucleotide polymorphisms (SNPs) from the UK Biobank and FinnGen Biobank after quality control. Cox proportional hazards regression was performed to evaluate the associations and was expressed as hazard ratios (HRs) with 95% confidence intervals (CIs).ResultsDuring a median follow-up of 10.90 years, 4,090 new CRC cases were reported in the UK Biobank. The “best-fit” PRSs were constructed using 59 SNPs based on the UK Biobank cohort and FinnGen genome-wide association study summary data (R2 = 0.23%) and were divided into low (lowest quintile), intermediate (including second–fourth quintile), and high (highest quintile) genetic risk categories. The multivariate-adjusted Cox model revealed that participants with favorable lifestyles had HRs of 0.66 (95% CI = 0.60–0.72) for developing CRC vs. those with unfavorable lifestyles; low genetic risk was associated with a decreased risk of CRC (HR = 0.67, 95% CI =0.61–0.74) compared with those with high genetic risk. The HRs for low genetic risk participants with favorable lifestyles were 0.44 (95% CI =0.36–0.55) vs. participants with high genetic risk and unfavorable lifestyles. Among the participants with low, intermediate, or high genetic risk, the HRs of favorable vs. unfavorable lifestyles were 0.74, 0.64, and 0.72 (all p< 0.05).ConclusionsLow genetic risk and a favorable lifestyle were significantly associated with a decreased risk of CRC. A favorable lifestyle was associated with a lower CRC risk, regardless of genetic risk.https://www.frontiersin.org/articles/10.3389/fonc.2022.894086/fullcolorectal cancerpolygenic risk scoreslifestyle factorsepidemiologyprevention |
| spellingShingle | E. Wu E. Wu Jun-Tao Ni Xin Chen Zhao-Hui Zhu Hong-Quan Xu Hong-Quan Xu Lin Tao Lin Tao Tian Xie Tian Xie Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen Frontiers in Oncology colorectal cancer polygenic risk scores lifestyle factors epidemiology prevention |
| title | Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen |
| title_full | Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen |
| title_fullStr | Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen |
| title_full_unstemmed | Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen |
| title_short | Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen |
| title_sort | genetic risk incident colorectal cancer and the benefits of adhering to a healthy lifestyle a prospective study using data from uk biobank and finngen |
| topic | colorectal cancer polygenic risk scores lifestyle factors epidemiology prevention |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.894086/full |
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