Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review
Background: Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent condition with onset in childhood and in many cases persisting into adulthood. Even though an increasing number of studies have investigated the efficacy of pharmacotherapy in the management of adult ADHD, few authors...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/10/1742 |
| _version_ | 1797472153377964032 |
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| author | Enrico Capuzzi Alice Caldiroli Anna Maria Auxilia Riccardo Borgonovo Martina Capellazzi Massimo Clerici Massimiliano Buoli |
| author_facet | Enrico Capuzzi Alice Caldiroli Anna Maria Auxilia Riccardo Borgonovo Martina Capellazzi Massimo Clerici Massimiliano Buoli |
| author_sort | Enrico Capuzzi |
| collection | DOAJ |
| description | Background: Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent condition with onset in childhood and in many cases persisting into adulthood. Even though an increasing number of studies have investigated the efficacy of pharmacotherapy in the management of adult ADHD, few authors have tried to identify the biological predictors of treatment response. Objectives: To summarize the available data about the biological markers of treatment response in adults affected by ADHD. Methods: A search on the main biomedical and psychological archives (PubMed, Embase, Scopus, and PsycINFO) was performed. Manuscripts in English, published up to May 2022 and having the biological predictors of treatment response in adults with ADHD as their main topic, were included. Results: A total of 3855 articles was screened. Twenty-two articles were finally included. Most of the manuscripts studied neuroimaging and electrophysiological factors as potential predictors of treatment response in adult ADHD patients. No reliable markers were identified until now. Promising findings on this topic regard genetic polymorphisms in snap receptor (SNARE) proteins and default mode network-striatum connectivity. Conclusions: Even though some biological markers seem promising for the prediction of treatment response in adults affected by ADHD, further studies are needed to confirm the available data in the context of precision medicine. |
| first_indexed | 2024-03-09T19:58:07Z |
| format | Article |
| id | doaj.art-8408a465a6f5404481fb1cdb9b5bb127 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T19:58:07Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-8408a465a6f5404481fb1cdb9b5bb1272023-11-24T00:51:13ZengMDPI AGJournal of Personalized Medicine2075-44262022-10-011210174210.3390/jpm12101742Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic ReviewEnrico Capuzzi0Alice Caldiroli1Anna Maria Auxilia2Riccardo Borgonovo3Martina Capellazzi4Massimo Clerici5Massimiliano Buoli6Psychiatric Department, Azienda Socio Sanitaria Territoriale Monza, 20900 Monza, ItalyPsychiatric Department, Azienda Socio Sanitaria Territoriale Monza, 20900 Monza, ItalyDepartment of Medicine and Surgery, University of Milano Bicocca, 20900 Monza, ItalyDepartment of Medicine and Surgery, University of Milano Bicocca, 20900 Monza, ItalyDepartment of Medicine and Surgery, University of Milano Bicocca, 20900 Monza, ItalyPsychiatric Department, Azienda Socio Sanitaria Territoriale Monza, 20900 Monza, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, 20122 Milan, ItalyBackground: Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent condition with onset in childhood and in many cases persisting into adulthood. Even though an increasing number of studies have investigated the efficacy of pharmacotherapy in the management of adult ADHD, few authors have tried to identify the biological predictors of treatment response. Objectives: To summarize the available data about the biological markers of treatment response in adults affected by ADHD. Methods: A search on the main biomedical and psychological archives (PubMed, Embase, Scopus, and PsycINFO) was performed. Manuscripts in English, published up to May 2022 and having the biological predictors of treatment response in adults with ADHD as their main topic, were included. Results: A total of 3855 articles was screened. Twenty-two articles were finally included. Most of the manuscripts studied neuroimaging and electrophysiological factors as potential predictors of treatment response in adult ADHD patients. No reliable markers were identified until now. Promising findings on this topic regard genetic polymorphisms in snap receptor (SNARE) proteins and default mode network-striatum connectivity. Conclusions: Even though some biological markers seem promising for the prediction of treatment response in adults affected by ADHD, further studies are needed to confirm the available data in the context of precision medicine.https://www.mdpi.com/2075-4426/12/10/1742attention-deficit/hyperactivity disorder (ADHD)adultmarkerstreatment responseoutcome |
| spellingShingle | Enrico Capuzzi Alice Caldiroli Anna Maria Auxilia Riccardo Borgonovo Martina Capellazzi Massimo Clerici Massimiliano Buoli Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review Journal of Personalized Medicine attention-deficit/hyperactivity disorder (ADHD) adult markers treatment response outcome |
| title | Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review |
| title_full | Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review |
| title_fullStr | Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review |
| title_full_unstemmed | Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review |
| title_short | Biological Predictors of Treatment Response in Adult Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review |
| title_sort | biological predictors of treatment response in adult attention deficit hyperactivity disorder adhd a systematic review |
| topic | attention-deficit/hyperactivity disorder (ADHD) adult markers treatment response outcome |
| url | https://www.mdpi.com/2075-4426/12/10/1742 |
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