Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the US National Health and Nutrition Examination Survey, 1999–2018
The effect of the antioxidant capacity of diet and its distribution across three meals on mortality risk among cancer patients remains unexplored. We aimed to prospectively investigate the association of dietary total antioxidant capacity (DAC) and its distribution across three meals with all-cause,...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1141380/full |
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| author | Peng Wang Shengnan Zhao Xiao Hu Qilong Tan Yaoyu Tan Dan Shi Dan Shi |
| author_facet | Peng Wang Shengnan Zhao Xiao Hu Qilong Tan Yaoyu Tan Dan Shi Dan Shi |
| author_sort | Peng Wang |
| collection | DOAJ |
| description | The effect of the antioxidant capacity of diet and its distribution across three meals on mortality risk among cancer patients remains unexplored. We aimed to prospectively investigate the association of dietary total antioxidant capacity (DAC) and its distribution across three meals with all-cause, cancer, and noncancer mortality among cancer survivors. We included 5,009 patients with cancer from the National Health and Nutrition Examination Survey conducted between 1999 and 2018. The adjusted hazard ratio (aHR) was estimated using the survey-weighted Cox proportional hazards model. During a median follow-up of 7.9 years, 1811 deaths, including 575 cancer-related deaths, were recorded. Among cancer survivors, compared with participants in the lowest quartile of total DAC from three meals, those in the highest quartile had a 24% decreased risk of noncancer mortality (aHR = 0.76, 95% confidence interval [CI]: 0.60–0.92), but not of all-cause and cancer mortality (each p trend >0.1). However, this association became insignificant for total DAC after excluding dinner DAC. In addition, higher dinner DAC rather than breakfast or lunch DAC was associated with a 21% lower risk of all-cause mortality (aHR = 0.79, 95% CI: 0.65–0.98) and 28% lower risk of noncancer mortality (aHR = 0.72, 95% CI: 0.57–0.90). Similar associations were found for ΔDAC (dinner DAC − breakfast DAC) with noncancer mortality (aHR = 0.56, 95% CI: 0.38–0.83), but DAC was not associated with cancer mortality (p trend >0.3). Among cancer survivors, total DAC from three meals was associated with reduced noncancer mortality, with the primary effect attributable to increased DAC intake from dinner. Our findings emphasize that DAC consumption from dinner should be advocated to reduce mortality risk in cancer survivors. |
| first_indexed | 2024-03-13T00:56:10Z |
| format | Article |
| id | doaj.art-8408dd8c10694d0daf22b68b19f83efb |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T00:56:10Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-8408dd8c10694d0daf22b68b19f83efb2023-07-06T20:09:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-07-011010.3389/fnut.2023.11413801141380Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the US National Health and Nutrition Examination Survey, 1999–2018Peng Wang0Shengnan Zhao1Xiao Hu2Qilong Tan3Yaoyu Tan4Dan Shi5Dan Shi6Department of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Nutrition Food and Children’s Health, School of Public Health, Weifang Medical University, Weifang, ChinaKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University, Chongqing, ChinaResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaThe effect of the antioxidant capacity of diet and its distribution across three meals on mortality risk among cancer patients remains unexplored. We aimed to prospectively investigate the association of dietary total antioxidant capacity (DAC) and its distribution across three meals with all-cause, cancer, and noncancer mortality among cancer survivors. We included 5,009 patients with cancer from the National Health and Nutrition Examination Survey conducted between 1999 and 2018. The adjusted hazard ratio (aHR) was estimated using the survey-weighted Cox proportional hazards model. During a median follow-up of 7.9 years, 1811 deaths, including 575 cancer-related deaths, were recorded. Among cancer survivors, compared with participants in the lowest quartile of total DAC from three meals, those in the highest quartile had a 24% decreased risk of noncancer mortality (aHR = 0.76, 95% confidence interval [CI]: 0.60–0.92), but not of all-cause and cancer mortality (each p trend >0.1). However, this association became insignificant for total DAC after excluding dinner DAC. In addition, higher dinner DAC rather than breakfast or lunch DAC was associated with a 21% lower risk of all-cause mortality (aHR = 0.79, 95% CI: 0.65–0.98) and 28% lower risk of noncancer mortality (aHR = 0.72, 95% CI: 0.57–0.90). Similar associations were found for ΔDAC (dinner DAC − breakfast DAC) with noncancer mortality (aHR = 0.56, 95% CI: 0.38–0.83), but DAC was not associated with cancer mortality (p trend >0.3). Among cancer survivors, total DAC from three meals was associated with reduced noncancer mortality, with the primary effect attributable to increased DAC intake from dinner. Our findings emphasize that DAC consumption from dinner should be advocated to reduce mortality risk in cancer survivors.https://www.frontiersin.org/articles/10.3389/fnut.2023.1141380/fullDACdinnernoncancer mortalityNHANESnutrition |
| spellingShingle | Peng Wang Shengnan Zhao Xiao Hu Qilong Tan Yaoyu Tan Dan Shi Dan Shi Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the US National Health and Nutrition Examination Survey, 1999–2018 Frontiers in Nutrition DAC dinner noncancer mortality NHANES nutrition |
| title | Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the US National Health and Nutrition Examination Survey, 1999–2018 |
| title_full | Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the US National Health and Nutrition Examination Survey, 1999–2018 |
| title_fullStr | Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the US National Health and Nutrition Examination Survey, 1999–2018 |
| title_full_unstemmed | Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the US National Health and Nutrition Examination Survey, 1999–2018 |
| title_short | Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the US National Health and Nutrition Examination Survey, 1999–2018 |
| title_sort | association of dietary total antioxidant capacity and its distribution across three meals with all cause cancer and non cancer mortality among cancer survivors the us national health and nutrition examination survey 1999 2018 |
| topic | DAC dinner noncancer mortality NHANES nutrition |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1141380/full |
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