Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein

Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein

ABSTRACT Nullbasic is a derivative of the HIV-1 transactivator of transcription (Tat) protein that strongly inhibits HIV-1 replication in lymphocytes. Here we show that lentiviral vectors that constitutively express a Nullbasic-ZsGreen1 (NB-ZSG1) fusion protein by the eEF1α promoter led to robust lo...

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Bibliographic Details
Main Authors: Hongping Jin, Dongsheng Li, Haran Sivakumaran, Mary Lor, Lina Rustanti, Nicole Cloonan, Shivangi Wani, David Harrich
Format: Article
Language:English
Published: American Society for Microbiology 2016-09-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00518-16

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