The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients
The pathophysiology of several psychiatric diseases may entail disturbances in the hypothalamic–pituitary–adrenal (HPA) axis and metabolic pathways. Variations in how these effects present themselves may be connected to individual variances in clinical symptoms and treatment responses, such as the o...
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MDPI AG
2023-05-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/5/260 |
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| author | Hussein Sabit Areej Kassab Donia Alaa Shaza Mohamed Shaimaa Abdel-Ghany Mohamed Mansy Osama A. Said Mona A. Khalifa Halah Hafiz Asmaa M. Abushady |
| author_facet | Hussein Sabit Areej Kassab Donia Alaa Shaza Mohamed Shaimaa Abdel-Ghany Mohamed Mansy Osama A. Said Mona A. Khalifa Halah Hafiz Asmaa M. Abushady |
| author_sort | Hussein Sabit |
| collection | DOAJ |
| description | The pathophysiology of several psychiatric diseases may entail disturbances in the hypothalamic–pituitary–adrenal (HPA) axis and metabolic pathways. Variations in how these effects present themselves may be connected to individual variances in clinical symptoms and treatment responses, such as the observation that a significant fraction of participants do not respond to current antipsychotic drugs. A bidirectional signaling pathway between the central nervous system and the gastrointestinal tract is known as the microbiota–gut–brain axis. The large and small intestines contain more than 100 trillion microbial cells, contributing to the intestinal ecosystem’s incredible complexity. Interactions between the microbiota and intestinal epithelium can alter brain physiology and affect mood and behavior. There has recently been a focus on how these relationships impact mental health. According to evidence, intestinal microbiota may play a role in neurological and mental illnesses. Intestinal metabolites of microbial origin, such as short-chain fatty acids, tryptophan metabolites, and bacterial components that might stimulate the host’s immune system, are mentioned in this review. We aim to shed some on the growing role of gut microbiota in inducing/manipulating several psychiatric disorders, which may pave the way for novel microbiota-based therapies. |
| first_indexed | 2024-03-11T03:50:53Z |
| format | Article |
| id | doaj.art-84099f71caa04f099178e319f339db5c |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T03:50:53Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-84099f71caa04f099178e319f339db5c2023-11-18T00:57:01ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-05-014554080409910.3390/cimb45050260The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric PatientsHussein Sabit0Areej Kassab1Donia Alaa2Shaza Mohamed3Shaimaa Abdel-Ghany4Mohamed Mansy5Osama A. Said6Mona A. Khalifa7Halah Hafiz8Asmaa M. Abushady9Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, EgyptDepartment of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, EgyptDepartment of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, EgyptDepartment of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, EgyptDepartment of Environmental Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, EgyptDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Agricultural Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, EgyptFaculty of Art and Science, Samtah, Jazan University, Jazan 45142, Saudi ArabiaClinical Nutrition Department, Factually of Applied Medical Science, Umm Alqura University, Mecca 24382, Saudi ArabiaSchool of Biotechnology, Nile University, Giza 41516, EgyptThe pathophysiology of several psychiatric diseases may entail disturbances in the hypothalamic–pituitary–adrenal (HPA) axis and metabolic pathways. Variations in how these effects present themselves may be connected to individual variances in clinical symptoms and treatment responses, such as the observation that a significant fraction of participants do not respond to current antipsychotic drugs. A bidirectional signaling pathway between the central nervous system and the gastrointestinal tract is known as the microbiota–gut–brain axis. The large and small intestines contain more than 100 trillion microbial cells, contributing to the intestinal ecosystem’s incredible complexity. Interactions between the microbiota and intestinal epithelium can alter brain physiology and affect mood and behavior. There has recently been a focus on how these relationships impact mental health. According to evidence, intestinal microbiota may play a role in neurological and mental illnesses. Intestinal metabolites of microbial origin, such as short-chain fatty acids, tryptophan metabolites, and bacterial components that might stimulate the host’s immune system, are mentioned in this review. We aim to shed some on the growing role of gut microbiota in inducing/manipulating several psychiatric disorders, which may pave the way for novel microbiota-based therapies.https://www.mdpi.com/1467-3045/45/5/260psychiatric disordersgut microbiotagut–brain axismouth–gut axisprobiotics |
| spellingShingle | Hussein Sabit Areej Kassab Donia Alaa Shaza Mohamed Shaimaa Abdel-Ghany Mohamed Mansy Osama A. Said Mona A. Khalifa Halah Hafiz Asmaa M. Abushady The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients Current Issues in Molecular Biology psychiatric disorders gut microbiota gut–brain axis mouth–gut axis probiotics |
| title | The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients |
| title_full | The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients |
| title_fullStr | The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients |
| title_full_unstemmed | The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients |
| title_short | The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients |
| title_sort | effect of probiotic supplementation on the gut brain axis in psychiatric patients |
| topic | psychiatric disorders gut microbiota gut–brain axis mouth–gut axis probiotics |
| url | https://www.mdpi.com/1467-3045/45/5/260 |
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