Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited

Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited

The oxidation of proline to pyrroline-5-carboxylate (P5C) leads to the transfer of electrons to ubiquinone in mitochondria that express proline dehydrogenase (ProDH). This electron transfer supports Complexes CIII and CIV, thus generating the protonmotive force. Further catabolism of P5C forms gluta...

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Bibliographic Details
Main Authors:	Gergely Pallag, Sara Nazarian, Dora Ravasz, David Bui, Timea Komlódi, Carolina Doerrier, Erich Gnaiger, Thomas N. Seyfried, Christos Chinopoulos
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	International Journal of Molecular Sciences
Subjects:	proline dehydrogenase substrate-level phosphorylation coenzyme Q reducing equivalent
Online Access:	https://www.mdpi.com/1422-0067/23/9/5111

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